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公开(公告)号：US11435314B2
公开(公告)日：2022-09-06
申请号：US17067538
申请日：2020-10-09
IPC分类号： G01N27/414 , C12Q1/6874 , H01L29/78 , H01L27/088 , C12Q1/6818 , G01N33/543 , H01L29/423
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
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公开(公告)号：US10100357B2
公开(公告)日：2018-10-16
申请号：US15043296
申请日：2016-02-12
IPC分类号： C12Q1/68 , G06F19/22 , C12Q1/6874
摘要： In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array.
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公开(公告)号：US09964515B2
公开(公告)日：2018-05-08
申请号：US14862930
申请日：2015-09-23
发明人： Jonathan M. Rothberg , James Bustillo , Mark James Milgrew , Jonathan Schultz , David Marran , Todd Rearick , Kim L. Johnson
IPC分类号： G01N27/403 , G01N27/414 , C12Q1/68 , H01L21/82
CPC分类号： G01N27/4145 , C12Q1/6869 , C12Q1/6874 , G01N27/4148 , H01L21/82 , C12Q2565/607
摘要： An apparatus comprising a chemical field effect transistor array in a circuit-supporting substrate is disclosed. The transistor array has disposed on its surface an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid. The transistor array has a pitch of 10 μm or less and a sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region.
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