公开(公告)号：US20100093002A1

公开(公告)日：2010-04-15

申请号：US11974076

申请日：2007-10-10

Applicant: Jack R. Wands ,  Suzanne M. de la Monte ,  Alan H. Deutch ,  Hossein A. Ghanbari

Inventor： Jack R. Wands ,  Suzanne M. de la Monte ,  Alan H. Deutch ,  Hossein A. Ghanbari

IPC: G01N33/574 ,  G01N33/53

CPC classification number: A61K31/00 ,  A61K31/4412 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/40 ,  C12N9/0071 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/315 ,  C12N2799/027 ,  C12Q1/26 ,  C12Y114/11016 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/00 ,  G01N2500/10

Abstract: The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.

Abstract translation: 本发明的特征在于通过向哺乳动物施用抑制人天冬氨酰（天冬酰胺酰基）β-羟化酶（HAAH）的表达或酶活性的化合物（例如拮抗性抗体）来抑制哺乳动物的肿瘤生长和/或肿瘤侵袭的方法。 本发明还具有通过使哺乳动物的组织或体液与足以形成抗原决定簇的条件与HAAH多肽结合的抗体接触来诊断哺乳动物的恶性肿瘤（例如胰腺癌）的生长的方法， 抗体复合物和/或检测抗原 - 抗体复合物。

公开(公告)号：US20100010203A1

公开(公告)日：2010-01-14

申请号：US12553599

申请日：2009-09-03

Applicant: K. Dane Wittrup ,  Jack R. Wands ,  Yik Andy Yeung

Inventor： K. Dane Wittrup ,  Jack R. Wands ,  Yik Andy Yeung

IPC: C07K16/00

CPC classification number: C07K16/40 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/57407 ,  G01N2500/00

Abstract: Antibodies, or antigen-binding portions thereof, to aspartyl (asparaginyl) β-hydroxylase are provided. The anti-aspartyl (asparaginyl) β-hydroxylase antibodies, or antigen-binding portions thereof, can modulate activity of aspartyl (asparaginyl) β-hydroxylase.

Abstract translation: 提供了天冬氨酰（天冬酰胺酰基）β-羟化酶的抗体或其抗原结合部分。 抗天冬氨酰基（天冬酰胺酰基）β-羟化酶抗体或其抗原结合部分可调节天冬氨酰（天冬酰胺酰基）β-羟化酶的活性。

公开(公告)号：US06835370B2

公开(公告)日：2004-12-28

申请号：US09859604

申请日：2001-05-17

Applicant: Jack R. Wands ,  Suzanne M. de la Monte ,  Alan H. Deutch ,  Hossein A. Ghanbari

Inventor： Jack R. Wands ,  Suzanne M. de la Monte ,  Alan H. Deutch ,  Hossein A. Ghanbari

IPC: A61K5110

CPC classification number: C07K16/40 ,  A61K31/00 ,  A61K31/4412 ,  A61K47/6865 ,  A61K49/16 ,  A61K51/1093 ,  A61K2039/505 ,  C07K14/47 ,  C12N9/0071 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/315 ,  C12N2799/027 ,  C12Q1/26 ,  C12Y114/11016 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/00 ,  G01N2500/10

Abstract: The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.

Abstract translation: 本发明的特征在于通过使哺乳动物的细胞或体液与结合人天冬氨酰（天冬酰胺酰基）β-羟化酶（HAAH）多肽的抗体接触来诊断和抑制哺乳动物恶性肿瘤生长的方法。 免疫产生HAAH特异性免疫应答的方法也在本发明的范围内。

公开(公告)号：US06770797B2

公开(公告)日：2004-08-03

申请号：US09872968

申请日：2001-06-01

Applicant: Jack R. Wands ,  Suzanne M. de la Monte

Inventor： Jack R. Wands ,  Suzanne M. de la Monte

IPC: G01N3300

CPC classification number: C07K14/4711 ,  A01K67/0275 ,  A01K2267/0312 ,  A61K48/00 ,  C12N15/67

Abstract: The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.

Abstract translation: 本发明的特征在于阿尔茨海默病的非转基因模型，用于在哺乳动物中诱导延长的体内基因表达的方法，以及抑制阿尔茨海默病相关神经元细胞死亡的方法。

公开(公告)号：US5929220A

公开(公告)日：1999-07-27

申请号：US683262

申请日：1996-07-18

Applicant: Shuping Tong ,  Jisu Li ,  Jack R. Wands

Inventor： Shuping Tong ,  Jisu Li ,  Jack R. Wands

IPC: A01K67/027 ,  A61K31/00 ,  A61K38/00 ,  A61K39/29 ,  A61K39/395 ,  A61K48/00 ,  A61P31/00 ,  A61P31/20 ,  A61P37/00 ,  C07K14/705 ,  C07K16/28 ,  C12N15/09 ,  C07H21/00 ,  C07H21/04 ,  C12N15/10

CPC classification number: C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  C07K2319/00

Abstract: The invention features a purified nucleic acid that encodes a member of the hepadnavirus family of cellular receptors. The receptor is a 170 kD cell surface glycoprotein, and is referred to as the p170 receptor. The pre-S domain of the duck hepatitis B virus envelope protein binds the p170 receptor at a major neutralizing epitope, within which are two basic amino acids required for virion-receptor interaction.

Abstract translation: 本发明的特征在于一种纯化的核酸，其编码细胞受体的肝炎病毒家族的成员。 受体是170kD的细胞表面糖蛋白，被称为p170受体。 鸭乙型肝炎病毒包膜蛋白的前S结构域以主要中和表位结合p170受体，其中是病毒 - 受体相互作用所需的两种碱性氨基酸。

公开(公告)号：US5830670A

公开(公告)日：1998-11-03

申请号：US454557

申请日：1995-05-30

Applicant: Suzanne de la Monte ,  Jack R. Wands

Inventor： Suzanne de la Monte ,  Jack R. Wands

IPC: A61K38/00 ,  A61K49/00 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/68 ,  G01N33/53 ,  G01N33/48 ,  C12Q1/08

CPC classification number: C07K14/474 ,  A61K49/0008 ,  C07K14/47 ,  C07K14/4711 ,  C07K16/18 ,  C12Q1/6883 ,  G01N33/6878 ,  G01N33/6896 ,  A61K38/00 ,  C12Q2600/158 ,  G01N2800/2821 ,  Y10S530/839

Abstract: The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and vectors which contain the genes coding for the neuronal thread proteins. This invention is also directed to substantially pure neural thread protein, immunodiagnostic and molecular diagnostic methods to detect the presence of neural thread proteins, and the use of nucleic acid sequences which code for neural thread proteins in gene therapy.

公开(公告)号：US5011771A

公开(公告)日：1991-04-30

申请号：US102766

申请日：1987-09-24

Applicant: Dominique Bellet ,  Jack R. Wands

Inventor： Dominique Bellet ,  Jack R. Wands

IPC: G01N33/543 ,  G01N33/574 ,  G01N33/577 ,  G01N33/76

CPC classification number: G01N33/54306 ,  G01N33/57476 ,  G01N33/577 ,  G01N33/76 ,  Y10S435/975 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S436/808 ,  Y10S436/813 ,  Y10S436/814 ,  Y10S436/815 ,  Y10S436/819

Abstract: The invention relates to an immunometric assay for a multivalent antigen in a sample which comprises forming a complex of the antigen together with multiple immobilized monoclonal antibodies against different epitopes of the antigen and with a detectably labeled soluble monoclonal antibody which is identical to one of the multiple immobilized antibodies. The labeled antibody associated with the complex is separated from the remaining soluble antibody and the detectably labeled antibody associated with the complex or unassociated with the complex is detected. Any one of the multiple immobilized monoclonal antibodies shows, by itself, substantially less binding towards the antigen in the immunometric assay, when used with itself or another monocolonal antibody in soluble labeled form, than when used with the multiple immobilized antibodies in combination.

Abstract translation: 本发明涉及样品中多价抗原的免疫测定法，其包括将抗原复合物与针对抗原的不同表位的多个固定的单克隆抗体和可检测标记的可溶性单克隆抗体形成，所述可溶单克隆抗体与多重抗原 固定化抗体。 与复合物相关的标记抗体与剩余的可溶性抗体分离，并检测与复合物相关的可检测标记的抗体或与复合物无关的抗体。 当与本身或可溶性标记形式的另一单克隆抗体一起使用时，与使用多种固定化抗体组合使用时，多个固定化单克隆抗体本身显示出与免疫测定中的抗原相当少的结合。

公开(公告)号：US4491632A

公开(公告)日：1985-01-01

申请号：US516672

申请日：1983-07-26

Applicant: Jack R. Wands ,  Vincent R. Zurawski, Jr.

Inventor： Jack R. Wands ,  Vincent R. Zurawski, Jr.

IPC: A61K39/42 ,  G01N33/577 ,  C12N5/00 ,  C12N15/00

CPC classification number: A61K39/42 ,  G01N33/577

Abstract: Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce monoclonal antibodies to individual antigenic determinates unique to hepatitis virus.

Abstract translation: 用于产生肝炎病毒单克隆抗体的细胞系通过用肝炎抗原免疫动物淋巴细胞来形成抗体产生细胞，然后与骨髓瘤细胞融合。 可以克隆所得体细胞杂交体。 这些克隆产生针对肝炎病毒特有的单个抗原决定因子的单克隆抗体。

公开(公告)号：US08158761B2

公开(公告)日：2012-04-17

申请号：US11909308

申请日：2005-09-21

Applicant: Jack R. Wands ,  Miran Kim

Inventor： Jack R. Wands ,  Miran Kim

IPC: C07K16/00

CPC classification number: G01N33/5067 ,  G01N33/5011

Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.

Abstract translation: 本说明书尤其提供了在癌症诊断和治疗中使用Wnt和FZD蛋白，基因，FZD和Wnt特异性抗体和探针并用于筛选测试化合物以治疗癌症的方法。 还公开了可用于治疗癌症如肝癌的化合物。

公开(公告)号：US20110124016A1

公开(公告)日：2011-05-26

申请号：US12955435

申请日：2010-11-29

Applicant: Jack R. Wands ,  Suzanne M. de la Monte ,  Alan H. Deutch ,  Hossein A. Ghanbari

Inventor： Jack R. Wands ,  Suzanne M. de la Monte ,  Alan H. Deutch ,  Hossein A. Ghanbari

IPC: G01N33/574

CPC classification number: A61K31/00 ,  A61K31/4412 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/40 ,  C12N9/0071 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/315 ,  C12N2799/027 ,  C12Q1/26 ,  C12Y114/11016 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/00 ,  G01N2500/10

Abstract: The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.

Abstract translation: 本发明的特征在于通过向哺乳动物施用抑制人天冬氨酰（天冬酰胺酰基）β-羟化酶（HAAH）的表达或酶活性的化合物（例如拮抗性抗体）来抑制哺乳动物的肿瘤生长和/或肿瘤侵袭的方法。 本发明还具有通过使哺乳动物的组织或体液与足以形成抗原决定簇的条件与HAAH多肽结合的抗体接触来诊断哺乳动物的恶性肿瘤（例如胰腺癌）的生长的方法， 抗体复合物和/或检测抗原 - 抗体复合物。