公开(公告)号：US4690757A

公开(公告)日：1987-09-01

申请号：US842494

申请日：1986-03-21

Applicant: Gregory Mathus ,  George Lyman ,  Kevin Looney

Inventor： Gregory Mathus ,  George Lyman ,  Kevin Looney

IPC: B01D29/01 ,  B01D35/02 ,  B01D46/10 ,  B01D46/54 ,  B01D61/18 ,  B01D63/08 ,  B01D13/00

CPC classification number: B01D46/543 ,  B01D29/012 ,  B01D46/0012 ,  B01D61/18 ,  B01D63/08 ,  B01D2277/20

Abstract: A small volume laboratory filter having a thin rectangular body and coaxial inlet and outlet sleeves connected to opposite ends thereof. A very thin filter cavity is formed in the body and lies in a plane inclined slightly to the common axis of the inlet and outlet sleeves. The cavity is divided by a filter membrane into extremely thin chambers, one communicating with the inlet sleeve and the other with the outlet sleeve. A rigid package for the filter is sealed across one end by a flexible cover which when stripped from the package exposes the inlet sleeve so that it may be readily engaged by a syringe nipple or other fluid source without the user having to touch the filter. When the inlet sleeve is engaged, the filter may be withdrawn from the package.

Abstract translation: 具有薄的矩形体的小体积实验室过滤器和连接到其相对端的同轴入口和出口套筒。 在体内形成非常薄的过滤腔，并且位于与入口和出口套筒的公共轴线稍微倾斜的平面内。 空腔被过滤膜分成非常薄的室，一个与入口套管相通，另一个与出口套管连通。 用于过滤器的刚性包装通过柔性盖密封在一端上，当从包装件剥离时，柔性罩暴露入口套筒，使得其可以容易地通过注射器管接头或其它流体源接合，而用户不必接触过滤器。 当入口套筒接合时，过滤器可以从包装件中取出。

公开(公告)号：USD260454S

公开(公告)日：1981-09-01

申请号：US037489

申请日：1979-06-20

Applicant: Pasquale L. Pepicelli, Jr. ,  David Roche ,  Gregory Mathus ,  Alan B. Lowry

Designer： Pasquale L. Pepicelli, Jr. ,  David Roche ,  Gregory Mathus ,  Alan B. Lowry

公开(公告)号：US20150030513A1

公开(公告)日：2015-01-29

申请号：US13952726

申请日：2013-07-29

Applicant: David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

Inventor： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC: B01L3/02

CPC classification number: B01L3/0237 ,  B01L3/0227 ,  B01L2200/022 ,  B01L2300/0829

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US08277757B2

公开(公告)日：2012-10-02

申请号：US12568801

申请日：2009-09-29

Applicant: Terrence Kelly ,  Richard Cote ,  Gregory Mathus

Inventor： Terrence Kelly ,  Richard Cote ,  Gregory Mathus

IPC: B01L3/00 ,  G01F19/00 ,  G01F25/00

CPC classification number: B01L3/0279 ,  B01L3/021 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2400/0487

Abstract: A pipette tip mounting shaft includes outwardly circumferentially extending locking lobes over which the pipette tip collar is mounted. The locking lobes preferably include an inclining ramp portion that gently flexes and distorts the pipette tip collar out-of-round as the mounting shaft is inserted into the pipette tip, rather than the stretching tip collar. Each locking lobe also includes a declining ramp portion which extends upward along the mounting shaft. The peak of the lobes is preferably curved. When the pipette tip is fully mounted on the mounting shaft, a locking ring on the inside surface of the tip collar engages the declining ramp of the lobes to provide an over-center engagement, however, the required ejection force is small.

Abstract translation: 移液管尖端安装轴包括向外周向延伸的锁定凸耳，移液管尖端套环安装在该凸起上。 锁定凸耳优选地包括倾斜斜面部分，当倾斜安装轴插入移液管尖端而不是拉伸尖端套环时，倾斜斜坡部分轻轻地弯曲和扭曲移液管尖端轴环。 每个锁定凸耳还包括沿安装轴向上延伸的下降斜面部分。 裂片的峰最好是弯曲的。 当移液管末端完全安装在安装轴上时，尖端套环的内表面上的锁定环接合凸角的下降斜面以提供过中心接合，然而，所需的弹出力很小。

公开(公告)号：US20120164037A1

公开(公告)日：2012-06-28

申请号：US13411675

申请日：2012-03-05

Applicant: David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

Inventor： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC: B01L3/02

CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US08122779B2

公开(公告)日：2012-02-28

申请号：US12422336

申请日：2009-04-13

Applicant: Gary E. Nelson ,  George P. Kalmakis ,  R. Laurence Keene ,  Joel Novak ,  Kenneth Steiner ,  Jonathon Finger ,  Gregory Mathus ,  Richard Cote

Inventor： Gary E. Nelson ,  George P. Kalmakis ,  R. Laurence Keene ,  Joel Novak ,  Kenneth Steiner ,  Jonathon Finger ,  Gregory Mathus ,  Richard Cote

IPC: G01N1/14

CPC classification number: B01L3/0234 ,  B01L2200/0605 ,  B01L2200/087 ,  B01L2200/148

Abstract: A hand-held electronic pipettor is designed particularly to be programmed and operated with one hand for the convenience of the user. It uses a capacitance touchpad control for programming, and a separate run button for the operating mode. Internal components are located so that the center of gravity of the pipettor is located within the palm of the user. Flash memory stores an empirically derived table that correlates aspiration volume to motor steps and a separate empirically derived table the correlates dispensing volumes to motor steps.

Abstract translation: 手持式电子移液器特别设计为一方面进行编程和操作，方便用户使用。 它使用电容式触摸板控件进行编程，另外还有一个运行模式的运行按钮。 内部部件被定位成使得移液器的重心位于使用者的手掌内。 闪存存储经验导出的表，其将抽吸体积与运动步骤相关联，以及单独的经验派生表将分配体积与运动步骤相关联。

公开(公告)号：US20110311410A1

公开(公告)日：2011-12-22

申请号：US13219823

申请日：2011-08-29

Applicant: David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

Inventor： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC: B01L3/02

CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US20090274587A1

公开(公告)日：2009-11-05

申请号：US12115005

申请日：2008-05-05

Applicant: David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

Inventor： David Earl Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

IPC: B01L3/02

CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：US20080095671A1

公开(公告)日：2008-04-24

申请号：US11552384

申请日：2006-10-24

Applicant: Gregory Mathus ,  Terrence Kelley ,  Richard Cote

Inventor： Gregory Mathus ,  Terrence Kelley ,  Richard Cote

IPC: B01L3/02

CPC classification number: B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/087

Abstract: In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes located above a stop member and a lower sealing section located below the stop member. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft. The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft between the stop member and the upper end of the locking lobes, thus locking the pipette tip in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement between the lower sealing section of the mounting shaft and the sealing ring in the upper end of the barrel of the pipette tip.

Abstract translation: 一方面，本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴包括位于下密封部分上方的锁定部分。 锁定部分具有位于止动构件上方的向外延伸的锁定凸角和位于止动构件下方的下部密封部分。 当安装轴完全插入到匹配的一次性移液管尖端的轴环中时，尖端锁定在安装轴上。 移液管尖端的孔包括将其上部套环与位于周向架下方的顶部密封区域分开的圆周架或肩部。 尖端衣领优选地包括位于或靠近用于安装轴的上部开口的锁定环。 颈圈的尺寸，特别是其圆周架和锁定环之间的距离被选择成与止动构件和锁定瓣的上端之间的安装轴的尺寸相匹配，从而将移液管尖端锁定在 安全可靠的位置和方向，同时使用符合人体工程学的插拔力。 锁定凸耳优选地包括斜坡部分，当斜面部分安装在插管头中时，该倾斜部分使得移液管尖端套环温度弯曲并变形，而不是拉伸尖端套环。 吸头顶端的圆周架在顶端套环和筒体之间隔开了桶的上端的密封区域的变形，从而促进了安装轴的下密封部分与上端的密封环之间的可靠密封接合 的移液管尖端的桶。

公开(公告)号：USRE38214E1

公开(公告)日：2003-08-12

申请号：US09760250

申请日：2001-01-12

Applicant: William J. Lacey ,  Gregory Mathus ,  Paul M. Szlosek

Inventor： William J. Lacey ,  Gregory Mathus ,  Paul M. Szlosek

IPC: B01L300

CPC classification number: B01L3/5085 ,  B01L2300/0829 ,  B01L2300/12 ,  B29C45/1418 ,  B29C45/14344 ,  B29C45/14778 ,  G01N21/03 ,  G01N21/25 ,  G01N21/33

Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate. One embodiment of the method includes steps of inserting a sheet of UV permeable material into a mold cavity that includes sections shaped to form the sidewalls of the plurality of wells, injecting molten plastic material into the mold cavity, and cooling the plastic material to form the microplate with the plastic material forming the sidewalls of each of the first and second wells and the sheet of UV permeable material forming the bottom of each of the first and second wells. Another embodiment of the method includes providing an upper plate defining sidewalls of at least one well, adhering an intermediate layer to the upper plate and adhering a sheet of UV permeable material to the intermediate layer. A further embodiment of the method includes inserting a sheet of material having at least one hole into a mold cavity, injecting a molten plastic material into the mold cavity and cooling the plastic material to form a microplate.