摘要:
The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.
摘要:
A method for producing an optical fiber is provided. The method includes the steps of drawing an optical fiber from a heated glass source in a furnace and introducing index perturbations to the optical fiber via a plurality of perturbation sources arranged at a plurality of different azimuthal locations. The index perturbations are introduced synchronously at different locations along the axial length of the fiber by the plurality of perturbation sources in a generally helical pattern on the outside surface of the fiber in one embodiment. According to another embodiment, the index perturbations are introduced by the plurality of perturbation sources at different frequencies.
摘要:
The present invention discloses a method and an apparatus for neighbor cell configuration and a method and an apparatus for femtocell base station configuration. The neighbor cell configuration method includes: obtaining information of at least one macro cell; obtaining neighbor cell information of the at least one macro cell; and performing neighbor cell configuration according to the information of the at least one macro cell and the neighbor cell information. With the method and apparatus for neighbor cell configuration and the method and apparatus for femtocell base station configuration, complete femtocell base station neighbor cell information is obtained so that a femtocell base station can be configured automatically. This avoids call drops during handovers and increases the success rate of handovers, and the implementation is easy.
摘要:
Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.
摘要:
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要:
Aryl GPR119 agonists are provided. These compounds are useful for the treatment of diabetic diseases, including Type II diabetes and other diseases associated with poor glycemic control.
摘要:
A system for simultaneously determining strain and temperature characteristics of an object comprising: (i) at least one optical fiber having at least two Brillouin peaks; (ii) at least one connector securing the optical fiber to the object to be monitored; (iii) a laser positioned to provide laser light to said at least one optical fiber; (iv) a device measuring frequencies of said at least two Brillouin peaks, and determining frequency shifts of said at least two Brillouin peaks for said at least one optical fiber along the length of fiber; and (v) a system calculating strain and temperature characteristics along said fiber, based on the coefficients of strain and temperature as well as the measured Brillouin frequency shifts for said optical fiber along the length of said optical fiber.
摘要:
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.
摘要:
The present invention relates to a process for the manufacture of alkanolamide containing compositions, and more particularly to a process of reacting a fatty acid and diethanolamine (DEA) which result in the formation of low levels of undesirable by products, particularly of bis-hydroxyethyl piperazine (BHEP).