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公开(公告)号：US20150315623A1
公开(公告)日：2015-11-05
申请号：US14269435
申请日：2014-05-05
申请人： Conagen Inc.
IPC分类号： C12P19/56 , C12N9/10 , C07H15/256
CPC分类号： C07H15/24 , C07H15/256 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/1051 , C12N9/1062 , C12P19/56 , C12Y204/01013 , C12Y204/01017
摘要： Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D2, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
摘要翻译： 披露了一种称为新蛇菊苷D2的甜菊糖苷。 雷鲍迪苷D2具有连接到糖苷配基甜菊醇的五个β-葡糖基单元。 还公开了用于制备新蛇菊苷D2，UDP-糖基转移酶融合酶的方法和用于生产新蛇菊苷D和莱鲍迪甙E的方法。
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22.发明公开公开(公告)号：US20240327368A1
公开(公告)日：2024-10-03
申请号：US18492054
申请日：2023-10-23
申请人： Conagen Inc.
发明人： Haiyun Pan , Hui Chen , Oliver Yu , Xiaoran Fu
IPC分类号： C07D309/30 , C07D307/32 , C12N9/02 , C12R1/19
CPC分类号： C07D309/30 , C07D307/32 , C12N9/0071 , C12R2001/19
摘要： The present disclosure relates, at least in part, to the production of delta-lactones and gamma-lactones from fatty acid substrates (e.g., fatty acid substrates of C16-C25) via a batch fermentation method in an engineered microbe using a recombinant cytochrome P450 monooxygenase.
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公开(公告)号：US20240287561A1
公开(公告)日：2024-08-29
申请号：US18463336
申请日：2023-09-08
申请人： Conagen Inc.
发明人： Hui Chen , Manuel Garcia Venegas , Oliver Yu , Michael Nazaro , Andrew Stewart
IPC分类号： C12P17/08 , C07D313/00
CPC分类号： C12P17/08 , C07D313/00
摘要： Provided herein are biosynthetic methods for producing lactones, such as macrocyclic lactones, from fatty acids. The lactones produced using and/or during the biosynthetic methods are also provided.
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公开(公告)号：US20220411843A1
公开(公告)日：2022-12-29
申请号：US17819423
申请日：2022-08-12
申请人： Conagen Inc.
发明人： Guohong Mao , Michael Batten , Oliver Yu
摘要： The present invention relates, at least in part, to the production of steviol glycoside rebaudioside I through the use of variant UGT enzymes having activity to transfer a glucosyl group from UDP-glucose to rebaudioside A to produce rebaudioside I.
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公开(公告)号：US11414689B2
公开(公告)日：2022-08-16
申请号：US16725242
申请日：2019-12-23
申请人： Conagen Inc.
发明人： Guohong Mao , Jacob Edward Vick , Michael Batten , Oliver Yu
IPC分类号： C12P19/56
摘要： The present disclosure relates to the use of beta-glucosidase to enhance the production efficiency of desired steviol glycosides, such as rebaudioside M (reb M).
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公开(公告)号：US20220090158A1
公开(公告)日：2022-03-24
申请号：US17487532
申请日：2021-09-28
申请人： Conagen Inc.
摘要： The present disclosure relates to the biosynthesis of UDP-Rhamnose and recombinant polypeptides having enzymatic activity useful in the relevant biosynthetic pathways for producing UDP-Rhamnose. The present invention also provides a method for preparing a steviol glycoside composition comprising at least one rhamnose-containing steviol glycoside.
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公开(公告)号：US20200224232A1
公开(公告)日：2020-07-16
申请号：US16714659
申请日：2019-12-13
申请人： Conagen Inc.
发明人： Jixiang Han , Hui Chen , Oliver Yu
摘要： Disclosed are methods for ergothioneine biosynthesis. More particularly, the present disclosure relates to methods for microbial ergothioneine biosynthesis.
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公开(公告)号：US09527880B2
公开(公告)日：2016-12-27
申请号：US15016589
申请日：2016-02-05
申请人： Conagen, Inc.
IPC分类号： C07H15/24 , C07H15/256 , C12N9/10 , C12P19/56
CPC分类号： C07H15/24 , C07H15/256 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/1051 , C12N9/1062 , C12P19/56 , C12Y204/01013 , C12Y204/01017
摘要： Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D3, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
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公开(公告)号：US09522929B2
公开(公告)日：2016-12-20
申请号：US14269435
申请日：2014-05-05
申请人： Conagen Inc.
IPC分类号： C12P19/56 , C07H15/24 , C07H15/256 , C12N9/10
CPC分类号： C07H15/24 , C07H15/256 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/1051 , C12N9/1062 , C12P19/56 , C12Y204/01013 , C12Y204/01017
摘要： Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D3, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
摘要翻译： 披露了一种称为新蛇菊苷D3的甜菊糖苷。 雷鲍迪苷D3具有连接于糖苷配基甜菊醇的五个β-D-葡糖基单元。 还公开了用于生产新蛇菊苷D3，UDP-糖基转移酶融合酶的方法和用于生产新蛇菊苷D和莱鲍迪甙E的方法。
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公开(公告)号：US20160208303A1
公开(公告)日：2016-07-21
申请号：US15016725
申请日：2016-02-05
申请人： Conagen, Inc.
IPC分类号： C12P19/56
CPC分类号： C07H15/24 , C07H15/256 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/1051 , C12N9/1062 , C12P19/56 , C12Y204/01013 , C12Y204/01017
摘要： Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D2, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
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