公开(公告)号：US10058620B2

公开(公告)日：2018-08-28

申请号：US14621904

申请日：2015-02-13

Applicant: Gang Cheng ,  Qiong Tang ,  Bin Cao

Inventor： Gang Cheng ,  Qiong Tang ,  Bin Cao

IPC: A61K47/48 ,  A61K48/00 ,  C12N15/87 ,  A61K47/61 ,  A61K47/64

CPC classification number: A61K47/645 ,  A61K47/61 ,  C12N15/87 ,  C12N2810/40

Abstract: One or more embodiments of the present invention provide a novel composition for gene delivery are directed to a group of polysaccharide polymers, having one or more nucleic acid delivery side chains comprising cationic peptides. In some embodiments, these cationic peptides condense and physically bond to one or more nucleic acids to form a polysaccharide-nucleic acid complex that permits delivery to and transfection of the nucleic acid(s) into cells. In some embodiments, the polysaccharide polymers of the present invention may also have one or more zwitterionic side chains and/or reactive side chains.

公开(公告)号：US09013905B2

公开(公告)日：2015-04-21

申请号：US14007274

申请日：2012-01-19

Applicant: Qinggan Zeng ,  Bin Cao ,  Zhaowei Ma ,  Yingping Wang

Inventor： Qinggan Zeng ,  Bin Cao ,  Zhaowei Ma ,  Yingping Wang

IPC: H02M7/06 ,  H01F30/14 ,  H01F30/12 ,  H01F38/06 ,  H02P13/06

CPC classification number: H01F30/14 ,  H01F30/12 ,  H01F38/06 ,  H02M7/06 ,  H02P13/06

Abstract: A three-phase 48-pulse rectifier transformer includes two 24-pulse rectifier transformers phase-shifted through valve-side output windings. Each 24-pulse rectifier transformer has two sets of grid-side input windings and four sets of valve-side output windings. The two sets of grid-side input windings are connected in parallel and axially arranged in a split manner. Among the four sets of valve-side output windings, two sets of valve-side output windings are radially arranged in a split manner corresponding to one set of grid-side input windings, and the other two sets of valve-side output windings are also radially arranged in a split manner corresponding to the other set of grid-side input windings. The two sets of valve-side output windings that are radially split and the other two sets of valve-side output windings that are radially split are axially arranged in a split manner. The grid-side input windings of the two 24-pulse rectifier transformers are phase-shifted with respect to each other. In this way, a uniform difference of 7.5° is produced in voltages of the eight sets of valve-side output windings of the two 24-pulse rectifier transformers, and the eight sets of valve-side output windings of the two 24-pulse rectifier transformers are correspondingly connected to rectifiers to form a uniform 48-pulse rectifier transformer, which not only reduces the harmonic current generated by the rectifier, but also improves the load capacity of the rectifier.

Abstract translation: 三相48脉冲整流变压器包括两个通过阀侧输出绕组相移的24脉冲整流变压器。 每个24脉冲整流变压器有两组电网侧输入绕组和四组阀侧输出绕组。 两组电网侧输入绕组并联连接并以分开的方式轴向布置。 在四组阀侧输出绕组中，两组阀侧输出绕组以对应于一组电网侧输入绕组的分开方式径向布置，另外两组阀侧输出绕组也是 以对应于另一组电网侧输入绕组的分开方式径向布置。 径向分离的两组阀侧输出绕组和径向分开的另外两组阀侧输出绕组以分开的方式轴向布置。 两个24脉冲整流变压器的电网侧输入绕组相对于彼此相移。 这样，在两个24脉冲整流变压器的八组阀侧输出绕组的电压中产生7.5°的均匀差，并且两个24脉冲整流器的八组阀侧输出绕组 变压器相应连接整流器，形成均匀的48脉冲整流变压器，不仅可以降低整流器产生的谐波电流，而且可以提高整流器的负载能力。

公开(公告)号：US08642603B2

公开(公告)日：2014-02-04

申请号：US12554129

申请日：2009-09-04

Applicant: Bin Cao ,  Vieroslava Gurunian ,  Sathapana Kongsamut ,  Raymond W. Kosley, Jr. ,  Rosy Sher ,  Ryan E. Hartung

Inventor： Bin Cao ,  Vieroslava Gurunian ,  Sathapana Kongsamut ,  Raymond W. Kosley, Jr. ,  Rosy Sher ,  Ryan E. Hartung

IPC: C07D491/04 ,  A61K31/519 ,  A61P25/28 ,  A61P25/22 ,  A61P25/18 ,  A61P25/06 ,  A61P25/02

CPC classification number: C07D498/04

Abstract: The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

Abstract translation: 本发明涉及一系列取代的二氢和四氢恶唑啉嘧啶酮，特别涉及一系列2-取代-2,3-二氢 - 恶唑并[3,2-a]嘧啶-7-酮和2-取代-2,2-二氧杂唑并[ （I）的3,5,6-四氢恶唑并[3,2-a]嘧啶-7-酮：其中p，n，X，Y，R1，R2，R3，R4，R5，R6， R7和R8如本文所定义。 本发明还涉及制备这些化合物的方法，包括新型中间体。 本发明的化合物是代谢型谷氨酸受体（mGluR），特别是mGluR2受体的调节剂。 因此，本发明的化合物可用作药物，特别是用于治疗和/或预防各种中枢神经系统疾病（CNS），包括但不限于急性和慢性神经变性疾病，精神病，抽搐，焦虑， 抑郁症，偏头痛，疼痛，睡眠障碍和呕吐。

公开(公告)号：US20130186749A1

公开(公告)日：2013-07-25

申请号：US13520894

申请日：2011-01-06

Applicant: Chongai Bao ,  Pu Zheng ,  Canming Xi ,  Bin Cao ,  Yi Yang ,  Jun Huang ,  Tao Yang ,  Zhaohong Yang

Inventor： Chongai Bao ,  Pu Zheng ,  Canming Xi ,  Bin Cao ,  Yi Yang ,  Jun Huang ,  Tao Yang ,  Zhaohong Yang

IPC: C25C3/08

CPC classification number: C25C3/08

Abstract: The present invention discloses a cell bottom structure of a reduction cell which comprises a reduction cell and a cathode bus, wherein the bottom of the reduction cell is provided with column-shaped cathode carbon blocks perpendicular to the bottom of the reduction cell, and a lower end of the column-shaped cathode carbon block is connected to the cathode bus. By means of inserting the column-shaped cathode carbon blocks perpendicular to the bottom of the reduction cell and connecting the lower end of the column-shaped cathode carbon block with the cathode bus, such that electrical current that guided from anode carbon blocks is guided through the molten aluminum to the column-shaped cathode carbon blocks and is downwardly guided out, the present invention reduces horizontal electrical current in the molten aluminum, such that the cathode extending into the molten aluminum can effectively reduce fluctuations of the molten aluminum to obtain a stable surface of the molten aluminum, thereby reducing a polar distance between a cathode and an anode and lowering cell voltage so as to achieve the object of lowering electricity consumption.

Abstract translation: 本发明公开了一种还原电池的电池底部结构，包括还原电池和阴极母线，其中还原电池的底部设有垂直于还原电池底部的柱状阴极碳块，下部 柱状阴极碳块的端部连接到阴极母线。 通过将垂直于还原电池底部的柱状阴极碳块插入并将柱状阴极碳块的下端与阴极母线相连接，使得从阳极碳块引导的电流被引导通过 熔融铝到柱状阴极碳块并被向下引导出来，本发明减少了熔融铝中的水平电流，使得延伸到熔融铝中的阴极可以有效地减少熔融铝的波动，从而获得稳定的 熔融铝的表面，从而减少阴极和阳极之间的极距离并降低电池电压，从而达到降低电力消耗的目的。

公开(公告)号：US09878049B2

公开(公告)日：2018-01-30

申请号：US14510442

申请日：2014-10-09

Applicant: Gang Cheng ,  Qiong Tang ,  Bin Cao

Inventor： Gang Cheng ,  Qiong Tang ,  Bin Cao

IPC: C12N15/11 ,  A61K47/48 ,  A61K31/4745 ,  A61K45/06 ,  A61K31/713 ,  A61K47/59 ,  A61K47/64

CPC classification number: A61K47/59 ,  A61K31/4745 ,  A61K31/713 ,  A61K45/06 ,  A61K47/645 ,  A61K2300/00

Abstract: A high drug loading system is described comprising of at least one anticancer drug; at least one peptide; and at least one nucleic acid.

公开(公告)号：US20150231274A1

公开(公告)日：2015-08-20

申请号：US14621904

申请日：2015-02-13

Applicant: Gang Cheng ,  Qiong Tang ,  Bin Cao

Inventor： Gang Cheng ,  Qiong Tang ,  Bin Cao

IPC: A61K47/48 ,  A61K48/00

CPC classification number: A61K47/645 ,  A61K47/61 ,  C12N15/87 ,  C12N2810/40

Abstract: One or more embodiments of the present invention provide a novel composition for gene delivery are directed to a group of polysaccharide polymers, having one or more nucleic acid delivery side chains comprising cationic peptides. In some embodiments, these cationic peptides condense and physically bond to one or more nucleic acids to form a polysaccharide-nucleic acid complex that permits delivery to and transfection of the nucleic acid(s) into cells. In some embodiments, the polysaccharide polymers of the present invention may also have one or more zwitterionic side chains and/or reactive side chains.

Abstract translation: 本发明的一个或多个实施方案提供用于基因递送的新组合物涉及一组多糖聚合物，其具有一个或多个包含阳离子肽的核酸递送侧链。 在一些实施方案中，这些阳离子肽缩合并物理键合到一个或多个核酸以形成允许将核酸递送至细胞并将其转染入细胞的多糖 - 核酸复合物。 在一些实施方案中，本发明的多糖聚合物也可以具有一个或多个两性离子侧链和/或反应性侧链。

公开(公告)号：US20130277212A1

公开(公告)日：2013-10-24

申请号：US13520932

申请日：2011-01-07

Applicant: Bin Cao ,  Tao Yang

Inventor： Bin Cao ,  Tao Yang

IPC: C25C7/02

CPC classification number: C25C7/02 ,  C25C3/08

Abstract: A cathode boss structure for an aluminum electrolytic cell is disclosed. The cathode boss is arranged on the top surface of the cathode carbon block or on the top of the gap between two cathode carbon blocks. The distance between cathode bosses is 400 mm-900 mm. The length of the throughout elongate cathode boss is 100-250 mm longer than that of cathode carbon block, and two ends thereof are directly embedded into the paste around lateral portion. The length of the embedded and butted cathode boss is in a range of 3000-3200 mm, two ends thereof are fixed by binding carbon blocks respectively, and the binding carbon blocks are embedded into the paste around lateral portion. The cross-section of the cathode boss structure is in the shape of rectangle or isosceles trapezoid. The cathode boss structure is applicable to all types of current electrolytic cells. The strip boss is implanted into the top surface of the cathode of the electrolytic cell conveniently and quickly when the lateral portion of the common electrolytic cell is rammed, thereby forming a “choking effect”, reducing the flow rate of the aluminum liquid layer, decreasing energy dissipation from the aluminum liquid layer, therefore improving the production stability of the electrolytic cell and reducing energy consumption.

Abstract translation: 公开了一种用于铝电解槽的阴极凸起结构。 阴极凸台布置在阴极碳块的顶表面上或两个阴极碳块之间的间隙顶部。 阴极凸台之间的距离为400mm-900mm。 整个细长阴极凸台的长度比阴极碳块的长度长100-250毫米，其两端直接嵌入围绕侧面部分的浆料中。 嵌入和对接的阴极凸台的长度在3000-3200mm的范围内，其两端分别通过粘结碳块固定，并且结合碳块被嵌入周围的浆料中。 阴极凸台结构的横截面呈矩形或等腰梯形。 阴极凸台结构适用于所有类型的电流电解槽。 当公共电解池的侧面部分被夯实时，带状凸起被方便且快速地注入电解槽阴极的上表面，从而形成“窒息效应”，从而降低铝液层的流速，降低 从铝液层消耗能量，从而提高电解槽的生产稳定性，降低能耗。

公开(公告)号：US20120305630A1

公开(公告)日：2012-12-06

申请号：US13512217

申请日：2010-11-17

Applicant: Tao Yang ,  Bin Cao

Inventor： Tao Yang ,  Bin Cao

IPC: B23K31/12 ,  B23K37/00 ,  B23K31/02

CPC classification number: C25C3/16 ,  B23K2103/10

Abstract: A device using the live welding method for aluminum electrolytic cell overhauling under series full current consists of short-circuit buses at the bottom of the cell (1), pillar buses (2), an anode bus (3), a balance bus (4), a inter-cell standby bus (5), a door-shaped pillar clamp (6), an arcuate clamp (7) of anode buses, a current conversion switch (8, a mechanical switching device (9) for the short-circuit port, a voltage sensor and wires thereof (10), a temperature sensor and wires thereof (11), a system (12) for data acquiring, displaying, analyzing and alarming, an A-side welding area (13), a B-side welding area (14) and compression-joint points (15) on pillar soft belts of overhauling cells; and the live welding method comprises the following steps: when welding is required to be performed in some zone, the currents of short-circuit buses at the bottom of the cell (1) and pillar buses (2) which influence the welding area most are cut off, the serial currents are shunted to other pillar buses (2), other buses at the bottom of the cell (1) and the inter-cell standby buses (5) such that the magnetic field intensity at the welding area can be lowered to the extent that welding can be performed so as to perform welding, and such a device and method can achieve live welding of aluminum electrolytic cells overhauling under series full current.

Abstract translation: 在串联全电流下使用铝电解电池检修的活焊方法的装置由电池底部的短路母线（1），支柱母线（2），阳极母线（3），平衡母线（4） ），单元间备用总线（5），门形柱式夹具（6），阳极母线的弓形夹具（7），电流转换开关（8），用于短路模块的机械开关装置（9） 电路端口，电压传感器及其电线（10），温度传感器及其电线（11），用于数据采集，显示，分析和报警的系统（12），A侧焊接区域（13），B 侧面焊接区域（14）和压缩接头点（15），活塞焊接方法包括以下步骤：当需要在某些区域进行焊接时，短路电流 电池底部的总线（1）和影响焊接区域的柱式总线（2）被切断，串联电流分流到其他 支柱总线（2），电池底部的其他总线（1）和电池间备用总线（5），使得焊接区域的磁场强度可以降低到可以进行焊接的程度，以便 进行焊接，这种装置和方法可以在串联全电流下实现铝电解电池的检修。

公开(公告)号：US07517889B2

公开(公告)日：2009-04-14

申请号：US11735760

申请日：2007-04-16

Applicant: Keith John Harris ,  Bin Cao

Inventor： Keith John Harris ,  Bin Cao

IPC: C07D239/46 ,  A61K31/505

CPC classification number: C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).

Abstract translation: 本发明涉及式（I）的化合物，其中Cy1，Cy2，L1，L2和R1如本文所定义，药物组合物包含药学上有效量的一种或多种式（I）化合物的混合物 与药学上可接受的载体和治疗患有PGD2介导的病症的患者的方法，包括但不限于过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症 ，伴有系统性肥大细胞活化，过敏性休克，支气管收缩，支气管炎，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍） 由于伴随瘙痒的行为（如刮伤和跳动），炎症，慢性阻塞性肺疾病 脑缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎等，通过向所述患者施用药学有效量的根据式（I）的化合物。

公开(公告)号：US20080010680A1

公开(公告)日：2008-01-10

申请号：US11691155

申请日：2007-03-26

Applicant: Bin Cao ,  Yong Wang

Inventor： Bin Cao ,  Yong Wang

IPC: G06F11/00

CPC classification number: H04L63/1416 ,  G06F21/554

Abstract: The embodiments of the present invention disclose an event detection method and device. The method includes: predefining event-based detection rules with a predicative context-free grammar; generating by parsing the detection rules a parsing table of pushdown automaton which supports parallel parsing; receiving an event to be detected; and analyzing by a controller the event to be detected according to the parsing table, to obtain a detection result. The present invention is especially applicable to detection of network attack events. The embodiments of the present invention detect the attacks with a predicative context-free grammar on the basis of events, and ensure a close combination of a protocol parsing process and an attack detection process, as well as a close combination of multiple attack detection rules, thus decreasing unnecessary calculations. In addition, with an optimized parallel pushdown automaton, the embodiments of the present invention can efficiently analyze the predicative context-free grammar. Consequently, besides hierarchical processing capability and state description capability, the embodiments of the present invention deliver high efficiency.

Abstract translation: 本发明的实施例公开了一种事件检测方法和装置。 该方法包括：使用预测上下文无关语法预定义基于事件的检测规则; 通过解析检测规则生成支持并行解析的下推自动机的解析表; 接收要检测的事件; 并由控制器根据解析表分析要检测的事件，以获得检测结果。 本发明特别适用于网络攻击事件的检测。 本发明的实施例基于事件来检测具有谓词上下文无关语法的攻击，并且确保协议解析过程和攻击检测过程的紧密组合以及多个攻击检测规则的紧密组合， 从而减少不必要的计算。 此外，利用优化的并行下推自动机，本发明的实施例可以有效地分析预测无上下文的语法。 因此，除了分层处理能力和状态描述能力之外，本发明的实施例提供高效率。