公开(公告)号：US20200179609A1

公开(公告)日：2020-06-11

申请号：US16687254

申请日：2019-11-18

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  A61M5/162 ,  A61M5/158 ,  A61M5/148 ,  A61M5/145 ,  A61M5/172 ,  A61M5/24 ,  B65B55/10 ,  B65B55/08 ,  B65B7/28 ,  B65B3/00

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US10537682B2

公开(公告)日：2020-01-21

申请号：US15047792

申请日：2016-02-19

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/142

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US09987428B2

公开(公告)日：2018-06-05

申请号：US14350687

申请日：2012-10-11

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/24 ,  A61M5/142

CPC classification number: A61M5/31 ,  A61M5/14244 ,  A61M5/1452 ,  A61M5/148 ,  A61M5/158 ,  A61M5/162 ,  A61M5/1626 ,  A61M5/172 ,  A61M5/2455 ,  A61M5/2466 ,  A61M2005/247 ,  A61M2005/2474 ,  A61M2005/3114 ,  A61M2207/00 ,  B65B3/003 ,  B65B7/2821 ,  B65B55/08 ,  B65B55/10

Abstract: An injector (100) may include a container (102) having a wall (110) with an interior surface (112) and a seal assembly (140) with an interior surface (142), the interior surfaces (110) of the wall (110) and the seal assembly (140) defining a closed sterile reservoir (150) filled with a drug product. The injector (100) may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle (180) having a point (182) disposed only partially through the seal assembly (140) in a storage state, and disposed through the interior surface (142) of the seal assembly (140) into the sterile reservoir (150) in a delivery state. Further, the injection may include an actuator (106) that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US20160354555A1

公开(公告)日：2016-12-08

申请号：US14913928

申请日：2014-10-22

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Lee Foster ,  Donald Busby ,  Stephanie Toy ,  Suhas Krishna ,  Francisca Tan-Malecki ,  Ferry Tamtoro

IPC: A61M5/44 ,  A61M5/31 ,  A61M5/172 ,  A61M5/142 ,  A61M5/162

Abstract: A drug delivery system includes a reservoir and a drug delivery device coupled to the reservoir. The drug delivery device also may include at least one temperature-sensitive component and a lock having locked and unlocked states. The system further includes an output device, and a controller coupled to the lock and the output device. The controller may also include a temperature sensor, or may be coupled to the temperature sensor. The controller is programmed or configured to determine if the temperature of a drug in the reservoir or of the temperature-sensitive component exceeds an upper limit or is below a lower limit, and to activate the lock in either event. The controller is also programmed or configured to determine, directly or indirectly, if the temperature subsequently is between the upper and lower limits, and to unlock lock as a consequence.

Abstract translation: 药物递送系统包括联接到储存器的储存器和药物输送装置。 药物递送装置还可以包括至少一个温度敏感组件和具有锁定和解锁状态的锁。 该系统还包括输出装置和耦合到锁和输出装置的控制器。 控制器还可以包括温度传感器，或者可以耦合到温度传感器。 控制器被编程或配置为确定储存器或温度敏感组件中的药物的温度是否超过上限或低于下限，并且在任一情况下激活锁定。 控制器也被编程或配置为直接或间接地确定温度是否在上限和下限之间，并因此解锁锁定。

公开(公告)号：US20160199582A1

公开(公告)日：2016-07-14

申请号：US15040335

申请日：2016-02-10

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  B65B55/10 ,  B65B55/08 ,  B65B3/00 ,  B65B7/28

CPC classification number: A61M5/31 ,  A61M5/14244 ,  A61M5/1452 ,  A61M5/148 ,  A61M5/158 ,  A61M5/162 ,  A61M5/1626 ,  A61M5/172 ,  A61M5/2455 ,  A61M5/2466 ,  A61M2005/247 ,  A61M2005/2474 ,  A61M2005/3114 ,  A61M2207/00 ,  B65B3/003 ,  B65B7/2821 ,  B65B55/08 ,  B65B55/10

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Abstract translation: 注射器可以包括具有内表面的壁和具有内表面的密封组件的容器，壁的内表面和密封组件限定了充满药物的封闭的无菌容器。 注射器还可以包括流体输送系统，该流体输送系统包括清洁的，未被加热的刚性容器针，其具有仅在部分地通过密封组件处于储存状态的点，并且设置成通过密封组件的内表面输送到无菌容器中 州。 此外，注射可以包括适于将容器针从储存状态移动到输送状态的致动器。