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    REAL-TIME ELECTRONIC CELL SENSING SYSTEM AND APPLICATIONS FOR CYTOTOXICITY PROFILING AND COMPOUND ASSAYS
    21.
    发明申请
    REAL-TIME ELECTRONIC CELL SENSING SYSTEM AND APPLICATIONS FOR CYTOTOXICITY PROFILING AND COMPOUND ASSAYS 有权
    实时电子细胞感测系统及其在细胞毒性分析和化合物测定中的应用

    公开(公告)号：US20130123136A1

    公开(公告)日：2013-05-16

    申请号：US13720124

    申请日：2012-12-19

    Applicant: ACEA BIOSCIENCES, INC

    Inventor： Yama A. Abassi ,  Xiaobo Wang ,  Xiao Xu

    IPC: C12Q1/02

    CPC classification number: C12Q1/025 ,  C12Q1/002 ,  G01N27/02 ,  G01N33/4836 ,  G01N33/5014 ,  G01N33/5438

    Abstract: A method of performing an assay of a response of two or more cell types to a test compound, including: providing a device for monitoring cell-substrate impedance, adding at least two different cell types to the device; adding at least one test compound to form at least two test compound wells; providing at least two control wells; monitoring impedance of the at least two test compound wells and of the at least two control wells at three or more time points after adding the at least one test compound; and analyzing measured impedance from the at least two test compound wells and from the at least two control wells at the three or more time points to obtain information on the response of the different cell types to the at least one test compound.

    Abstract translation: 一种对测试化合物进行两种或多种细胞类型的反应测定的方法，包括：提供用于监测细胞 - 基底阻抗的装置，向装置添加至少两种不同的细胞类型; 加入至少一种测试化合物以形成至少两个测试化合物孔; 提供至少两个对照孔; 在加入至少一种测试化合物之后，在三个或更多个时间点监测所述至少两个测试化合物孔和所述至少两个对照孔的阻抗; 以及在所述三个或更多个时间点分析来自所述至少两个测试化合物孔和所述至少两个对照孔的测量阻抗，以获得关于所述不同细胞类型对所述至少一种测试化合物的响应的信息。

    EGFR modulators and uses thereof
    28.
    发明授权
    EGFR modulators and uses thereof 有权
    EGFR调节剂及其用途

    公开(公告)号：US08685988B2

    公开(公告)日：2014-04-01

    申请号：US13917514

    申请日：2013-06-13

    Applicant: ACEA Biosciences Inc.

    Inventor： Xiao Xu ,  Xiaobo Wang ,  Long Mao ,  Li Zhao ,  Biao Xi

    IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC classification number: A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  A61K2300/00

    Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

    Abstract translation: 本发明涉及某些吡咯并嘧啶衍生物，含有它们的药物组合物及其使用方法，包括治疗肿瘤的方法和与激酶失调相关的相关疾病（如EGFR（包括HER），Alk，PDGFR），但是 途径。

    REAL TIME ELECTRONIC CELL SENSING SYSTEMS AND APPLICATIONS FOR CELL-BASED ASSAYS
    29.
    发明申请
    REAL TIME ELECTRONIC CELL SENSING SYSTEMS AND APPLICATIONS FOR CELL-BASED ASSAYS 审中-公开

    公开(公告)号：US20200348312A1

    公开(公告)日：2020-11-05

    申请号：US16833180

    申请日：2020-03-27

    Applicant: ACEA Biosciences, Inc.

    Inventor： Xiao Xu ,  Yama A. Abassi ,  Xiaobo Wang ,  Jiangbo Gan

    IPC: G01N33/68 ,  C12M1/12 ,  C12M1/34 ,  G01N33/50 ,  G01N33/483

    Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.

    Real time electronic cell sensing systems and applications for cell-based assays
    30.
    发明授权
    Real time electronic cell sensing systems and applications for cell-based assays 有权

    公开(公告)号：US10690677B2

    公开(公告)日：2020-06-23

    申请号：US15487349

    申请日：2017-04-13

    Applicant: ACEA Biosciences, Inc.

    Inventor： Xiao Xu ,  Yama A. Abassi ,  Xiaobo Wang ,  Jiangbo Gan

    IPC: G01N33/68 ,  C12M1/34 ,  C12M1/12 ,  G01N33/50 ,  G01N33/483

    Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.

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