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公开(公告)号：US20240025960A1
公开(公告)日：2024-01-25
申请号：US18450524
申请日：2023-08-16
发明人： Varun Kumar , Peter NAWROTH , Thomas FLEMING , Marcus MALL
IPC分类号： C07K14/705
CPC分类号： C07K14/70503 , C07K2319/09
摘要： The present invention relates to a phosphomimetic RAGE protein comprising an amino acid sequence that is at least 90% identical to a native mammalian RAGE isoform or fragment thereof wherein at least one serine present in the cytoplasmatic tail of the mammalian RAGE isoform is replaced by a phosphomimetic structure. The invention further relates to a polynucleotide encoding phosphomimetic RAGE protein and a vector comprising the polynucleotide. Finally, the invention relates to a composition comprising carrier and an active pharmaceutical ingredient, selected from the RAGE protein the vector for use in the treatment or prevention of a disease in a patient, wherein the disease is preferably selected from a disease initiated by impaired DNA repair, a disease initiated by increased DNA damage or a disease initiated by increased senescence.
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22.发明公开公开(公告)号：US20230295092A1
公开(公告)日：2023-09-21
申请号：US18186043
申请日：2023-03-17
发明人： Jens Cardinale , Martin Schaefer , Klaus Kopka , Matthias Eder , Ulrike Bauder-Wuest , Michael Eisenhut , Martina Benesova , Uwe Haberkorn , Frederik L. Giesel
IPC分类号： C07D213/61 , A61K51/04 , C07B59/00 , G01N33/574 , C07K7/02 , A61P35/00
CPC分类号： C07D213/61 , A61K51/0455 , C07B59/002 , G01N33/57434 , A61K51/04 , C07K7/02 , A61P35/00 , A61K38/00
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.
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公开(公告)号：US20230226229A1
公开(公告)日：2023-07-20
申请号：US17889655
申请日：2022-08-17
发明人： Ann-Christin EDER , Matthias EDER , Klaus KOPKA , Martin SCHAEFER , Ulrike BAUDER-WUEST , Uwe HABERKORN
IPC分类号： A61K51/04 , C07D403/14
CPC分类号： A61K51/0478 , C07D403/14
摘要： The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula
wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.-
公开(公告)号：US20220381770A1
公开(公告)日：2022-12-01
申请号：US17770877
申请日：2020-10-23
发明人： Frank MOMBURG , Marten MEYER , Inka ZOERNIG , Dirk JAEGER , Niels HALAMA , Iris KAISER
IPC分类号： G01N33/50 , C07K16/24 , C07K16/28 , C12N5/0783
摘要： The present invention relates to artificial Antigen Presenting Cells (aAPCs) comprising artificial Antigen Presenting Molecules (aAPMs) and, in particular, comprising dimers of the aAPMs as well as to methods for producing aAPCs. The invention further relates to compositions comprising the aAPCs and to vectors encoding the aAPMs of the aAPCs. Embodiments of the invention have been particularly developed for use in assays for determining an antigen-specific T cell response or a plurality of antigen-specific T cell responses and will be described hereinafter with reference to this application. However, it will be appreciated that the invention is not limited to this particular field of use.
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公开(公告)号：US20210053922A1
公开(公告)日：2021-02-25
申请号：US17079013
申请日：2020-10-23
发明人： Jens CARDINALE , Martin SCHAEFER , Klaus KOPKA , Matthias EDER , Ulrike BAUDER-WUEST , Michael EISENHUT , Martina BENESOVA , Uwe HABERKORN , Frederik L. GIESEL
IPC分类号： C07D213/61 , A61K51/04 , C07B59/00 , G01N33/574 , C07K7/02 , A61P35/00
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.
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公开(公告)号：US20200368374A1
公开(公告)日：2020-11-26
申请号：US16763667
申请日：2018-11-12
发明人： Ann-Christin EDER , Matthias EDER , Klaus KOPKA , Martin SCHAEFER , Ulrike BAUDER-WUEST , Uwe HABERKORN
IPC分类号： A61K51/04 , C07D403/14
摘要： The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition
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公开(公告)号：US20190352360A1
公开(公告)日：2019-11-21
申请号：US16468475
申请日：2017-03-06
发明人： Georg GDYNIA
摘要： The present invention relates to a high mobility group box 1 (HMGB1) polypeptide, wherein in said HMGB1 polypeptide at least one, preferably two, more preferably three, most preferably all four tyrosine residues at positions corresponding to amino acid positions Y109, Y144, Y155 and/or Y162 of human HMGB1 have been exchanged to an amino acid residue independently selected from glutamic acid, glutamine, aspartic acid, asparagine, homoglutamic acid (2-aminohexanedioic acid), and homoglutamine (2,6-diamino-6-oxohexanoic acid). The present invention further relates to a polynucleotide encoding a polypeptide according to the present invention, to a vector comprising said polynucleotide, and to a host cell comprising said polypeptide, said polynucleotide and/or said vector. Also, the present invention relates to methods, kits, and uses related thereto.
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28.发明授权公开(公告)号：US10254273B2
公开(公告)日：2019-04-09
申请号：US15505212
申请日：2015-08-11
IPC分类号： G01N33/50 , G01N33/68 , A61K31/4458
摘要： The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro-arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s).
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公开(公告)号：US10119135B2
公开(公告)日：2018-11-06
申请号：US14402586
申请日：2013-05-15
发明人： Marcus Mall , Raman Agrawal , Martina Muckenthaler
IPC分类号： C12N15/11 , C12N15/113 , A61K31/713 , A61K45/06 , C12Q1/6883 , A61K47/54
摘要： The present invention relates to the identification of microRNAs of the miR-148 family that are involved in the pathogenesis of chronic pulmonary diseases. The present invention relates to micro RNA of the miR-148 family selected from miR-148a, miR-148b and miR-152 for use in the diagnosis, prognosis, prevention and/or therapy of a chronic pulmonary disease. The present invention further relates to miR-148 inhibitors, pharmaceutical compositions comprising such inhibitors, their use in preventing and/or treating chronic pulmonary diseases, and methods for preventing and/or treating chronic pulmonary diseases. The present invention further relates to transgenic, non-human mammals and methods for identifying modulators of miR-148 and methods for diagnosis and/or prognosis of chronic pulmonary diseases.
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公开(公告)号：US20240123025A1
公开(公告)日：2024-04-18
申请号：US18330135
申请日：2023-06-06
发明人： Volker Cleeves , Stephan Urban , Ralf Kubitz
IPC分类号： A61K38/16 , A61K31/00 , A61K31/575 , A61K38/17 , C07K14/005 , C07K14/705 , C12N7/00 , G01N33/50 , G01N33/68 , G01N33/92
CPC分类号： A61K38/162 , A61K31/00 , A61K31/575 , A61K38/1709 , C07K14/005 , C07K14/705 , C12N7/00 , G01N33/5023 , G01N33/5067 , G01N33/6893 , G01N33/92 , C12N2730/10122 , C12N2730/10132 , G01N2333/705 , G01N2500/04 , G01N2500/10 , G01N2800/085
摘要： The present invention relates to lipopeptide-based compounds for use in the diagnosis, prevention and/or treatment of a liver disease or condition, preferably liver involved metabolic diseases, as well as in the control or modification of the cholesterol level or cholesterol uptake and, thus, diagnosis, prevention and/or treatment of a cardiovascular disease. The present invention furthermore relates to an in vitro or in vivo assay or method for testing or measuring the NTCP-mediated transport of test compound(s). The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a liver disease or condition, comprising administering a therapeutically effective amount of a lipopeptide-based compound to a patient. The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a cardiovascular disease.
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