- 专利标题: A DOUBLE-LABELED PROBE FOR MOLECULAR IMAGING AND USE THEREOF
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申请号: US16763667申请日: 2018-11-12
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公开(公告)号: US20200368374A1公开(公告)日: 2020-11-26
- 发明人: Ann-Christin EDER , Matthias EDER , Klaus KOPKA , Martin SCHAEFER , Ulrike BAUDER-WUEST , Uwe HABERKORN
- 申请人: Deutsches Krebsforschungszentrum , Ruprecht-Karls-Universitaet Heidelberg
- 优先权: EP17201264.3 20171113
- 国际申请: PCT/EP2018/080936 WO 20181112
- 主分类号: A61K51/04
- IPC分类号: A61K51/04 ; C07D403/14
摘要:
The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition
公开/授权文献
- US11452786B2 Double-labeled probe for molecular imaging and use thereof 公开/授权日:2022-09-27
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