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62 条记录 (耗时 0.025 秒)

    Method and System for Scenario Selection and Measurement of User Attributes and Decision Making in a Dynamic and Contextual Gamified Simulation
    24.
    发明申请
    Method and System for Scenario Selection and Measurement of User Attributes and Decision Making in a Dynamic and Contextual Gamified Simulation 审中-公开

    公开(公告)号：US20190388787A1

    公开(公告)日：2019-12-26

    申请号：US16436837

    申请日：2019-06-10

    申请人： Sriram Padmanabhan ,  Aarti Shyamsunder

    发明人： Sriram Padmanabhan ,  Aarti Shyamsunder

    IPC分类号： A63F13/60 ,  G09B19/00 ,  G09B9/00 ,  A63F13/48 ,  A63F13/55

    摘要： The present invention allows organizations to set up, and its users to experience, dynamic, realistic gamified simulations in a cost- and time-efficient manner, as a means of iteratively assessing and developing individuals' work-focused decision making. It also enables measurement of user attributes and the process of decision making involved at work, through the process of experiencing such simulations. By closely mirroring, or realistically simulating the way data changes with users' decisions or with events external or internal to the organization, the invention is able to faithfully reconstruct the work environment of the user, generate true-to-life responses and unobtrusively measure behavior under various simulated situations. Overcoming existing challenges involved in measuring personal attributes (such as leadership competencies or decision making) in dynamic simulations, the invention allows assignment of scores to users regardless of the specific dynamic and idiosyncratic stimuli they are exposed to within the simulation experience, using the invention's method and system.

    METHOD AND SYSTEM FOR ENHANCING IMAGE QUALITY
    26.
    发明申请
    METHOD AND SYSTEM FOR ENHANCING IMAGE QUALITY 有权
    用于增强图像质量的方法和系统

    公开(公告)号：US20140193093A1

    公开(公告)日：2014-07-10

    申请号：US14131979

    申请日：2012-09-11

    申请人： Shyam Vasudeva Rao ,  Chandrasekhar Kuppuswamy ,  Mahabaleswara Ram Bhatt ,  Sriram Padmanabhan

    发明人： Shyam Vasudeva Rao ,  Chandrasekhar Kuppuswamy ,  Mahabaleswara Ram Bhatt ,  Sriram Padmanabhan

    IPC分类号： G06T5/00

    CPC分类号： G06T5/002 ,  G06T5/003 ,  G06T5/008 ,  G06T5/20 ,  G06T2207/20012 ,  G06T2207/20032 ,  G06T2207/20192

    摘要： The present disclosure relates to image filtering techniques for enhancing image quality. In one embodiment, two filtering techniques are applied on an image. Firstly, an adaptive weighted median filtering operation is performed on an acquired low contrast image corrupted by impulsive noise. Subsequently, a guided image filtering on the image obtained from adaptive weighted median filtering operation to de-blur and enhance the contrast that ultimately assures to preserve the edges of the images. In addition, the image filtering for enhancing image quality is enhanced by several variations of data adaptive guided image filtering and adaptive window sizes for guided image filtering techniques.

    摘要翻译： 本公开涉及用于增强图像质量的图像滤波技术。 在一个实施例中，在图像上应用两种滤波技术。 首先，对由脉冲噪声损坏的获取的低对比度图像执行自适应加权中值滤波操作。 随后，对从自适应加权中值滤波操作获得的图像上的引导图像滤波进行去模糊并增强最终确保保留图像边缘的对比度。 此外，用于增强图像质量的图像滤波通过用于引导图像滤波技术的数据自适应引导图像滤波和自适应窗口尺寸的几种变化而增强。

    PROCESS FOR PURIFICATION OF RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR
    29.
    发明申请
    PROCESS FOR PURIFICATION OF RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR 审中-公开
    重组人粒细胞集落刺激因子的纯化方法

    公开(公告)号：US20120093765A1

    公开(公告)日：2012-04-19

    申请号：US13378973

    申请日：2010-06-07

    申请人： Sandeep Somani ,  Sriram Padmanabhan

    发明人： Sandeep Somani ,  Sriram Padmanabhan

    IPC分类号： A61K38/19 ,  C07K1/36 ,  C07K14/535 ,  C07K1/14

    CPC分类号： C07K14/535

    摘要： The present invention describes a novel process for large-scale purification of therapeutic grade quality of recombinant human GCSF from microbial cells, wherein the protein is expressed as inclusion bodies. The Inclusion bodies are solubilized and refolded under redox condition. The Redox condition is provided by using ascorbic acid, dehydroascorbic acid and reduced gluthathione. The process involves the novel use of aqueous two phase extraction step to purify refolded GCSF after removal of denaturant. After this step GCSF is further purified using chromatography techniques for removal of related impurities. The GCSF obtained has good purity and yields which are essential for a production scale process. The host cell related contaminants like proteins, DNA and endotoxins are reduced using the purification processes of the invention.

    摘要翻译： 本发明描述了一种从微生物细胞大规模纯化重组人GCSF治疗级质量的新方法，其中蛋白质被表达为包涵体。 包涵体在氧化还原条件下溶解并重折叠。 通过使用抗坏血酸，脱氢抗坏血酸和还原型谷胱甘肽来提供氧化还原条件。 该方法涉及新型使用水相两相萃取步骤，在去除变性剂后纯化重折叠的GCSF。 在该步骤之后，使用色谱技术进一步纯化GCSF以除去相关杂质。 获得的GCSF具有良好的纯度和产率，这对于生产规模过程至关重要。 使用本发明的纯化方法，宿主细胞相关的污染物如蛋白质，DNA和内毒素被还原。