Nucleic Acid Molecules Inducing RNA Interference, and Uses Thereof

    公开(公告)号:US20170335326A1

    公开(公告)日:2017-11-23

    申请号:US15474615

    申请日:2017-03-30

    Inventor: Dong Ki Lee

    Abstract: The present invention relates to an RNAi-inducing nucleic acid molecule having a new structure and the use thereof, and more particularly to a novel nucleic acid molecule having a structure comprising a first strand, which is 24-121 nt in length and comprises a region complementary to a target nucleic acid, and a second strand which is 13-21 nt in length and has a region that binds complementarily to the region of the first strand, which is complementary to the target nucleic acid, so that the nucleic acid molecule inhibits the expression of a target gene with increased efficiency, and to a method of inhibiting the expression of a target gene using the nucleic acid molecule. The nucleic acid molecule structure of the present invention increases the efficiency with which the nucleic acid molecule inhibits the target gene. Alternatively, the nucleic acid molecule of the present invention can either increase the ability of the siRNA to bind to the target gene or cause synergistic cleavage, by introduction of antisense DNA, antisense RNA, ribozyme or DNAzyme, thereby increasing the efficiency with which the nucleic acid molecule inhibits the target gene. In addition, when the nucleic acid molecule according to the present invention is used, the efficiency with which the target gene is inhibited can be maintained for an extended period of time. Accordingly, the RNAi-inducing nucleic acid molecule of the present invention can be effectively used for the treatment of cancer or viral infection in place of conventional siRNA molecules.

    METHOD AND APPARATUS FOR MANAGING MEMORY IN VIRTUAL MACHINE ENVIRONMENT
    29.
    发明申请
    METHOD AND APPARATUS FOR MANAGING MEMORY IN VIRTUAL MACHINE ENVIRONMENT 有权
    虚拟机环境中管理存储器的方法和装置

    公开(公告)号:US20140173227A1

    公开(公告)日:2014-06-19

    申请号:US13775955

    申请日:2013-02-25

    Abstract: A method and apparatus for managing a memory in a portable terminal including a main memory, a secondary memory, and a plurality virtual machines allocated by partitioning the main memory are provided. The method includes generating, by the virtual machines, monitoring information by monitoring access to the main memory and the secondary memory and swapping out with respect to the secondary memory; determining memory allocation amounts for each of the virtual machines by using the monitoring information; and allocating the main memory to the virtual machines in a partitioning scheme based on the determined memory allocation amounts.

    Abstract translation: 提供了一种用于管理便携式终端中的存储器的方法和装置,包括主存储器,副存储器和通过分割主存储器而分配的多个虚拟机。 该方法包括通过监视对主存储器和辅助存储器的访问以及相对于辅助存储器交换出来,由虚拟机生成监视信息; 通过使用监视信息确定每个虚拟机的存储器分配量; 以及基于所确定的存储器分配量,以分割方案将所述主存储器分配给所述虚拟机。

    PRESSURE SENSOR AND PRESSURE SENSING METHOD
    30.
    发明申请
    PRESSURE SENSOR AND PRESSURE SENSING METHOD 有权
    压力传感器和压力传感方法

    公开(公告)号:US20140060210A1

    公开(公告)日:2014-03-06

    申请号:US14018505

    申请日:2013-09-05

    CPC classification number: G01L1/16 H01L29/84

    Abstract: A pressure sensor and a pressure sensing method are provided. The pressure sensor includes a substrate; a sensor thin film transistor (TFT) disposed on the substrate and including a gate insulating layer, wherein the gate insulating layer includes an organic matrix in which piezoelectric inorganic nano-particles are dispersed; a power unit configured to apply an alternating current (AC) signal to a gate of the sensor TFT; and a pressure sensing unit configured to obtain a remnant polarization value based on a drain current which is generated in response to the AC signal and detected by the sensor TFT, and to sense a pressure based on the remnant polarization value.

    Abstract translation: 提供压力传感器和压力感测方法。 压力传感器包括基板; 设置在所述基板上并且包括栅极绝缘层的传感器薄膜晶体管(TFT),其中所述栅极绝缘层包括其中分散有压电无机纳米颗粒的有机基质; 功率单元,配置为向传感器TFT的栅极施加交流(AC)信号; 以及压力感测单元,被配置为基于根据所述AC信号产生并由所述传感器TFT检测的漏极电流获得残留极化值,并且基于所述剩余极化值感测压力。

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