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30 条记录 (耗时 0.048 秒)

    2,3-dihydroxyterephthalamides as highly effective metal ion sequestering compounds
    22.
    发明授权
    2,3-dihydroxyterephthalamides as highly effective metal ion sequestering compounds 失效
    2,3-二羟基对苯二甲酰胺作为高效金属离子螯合化合物

    公开(公告)号：US5049280A

    公开(公告)日：1991-09-17

    申请号：US331584

    申请日：1989-03-29

    申请人： Kenneth N. Raymond ,  Thomas M. Garrett ,  Peter W. Miller

    发明人： Kenneth N. Raymond ,  Thomas M. Garrett ,  Peter W. Miller

    IPC分类号： B01D15/04 ,  B01J45/00 ,  C22B3/32

    CPC分类号： C22B3/0024 ,  B01J45/00 ,  Y02P10/234

    摘要： The present invention relates to the use of a 2,3-dihydroxyterephthalamide of the structure (I): ) ##STR1## wherein A is selected from hydrogen or an organic linking group Y attached to a solid substrate Q,R.sub.1 is independently selected from alkyl having from 1 to 20 carbon atoms, or aryl having from 6 to 14 carbon atoms, andR.sub.2 is selected from R.sub.1 or an organic linking group Z bonded to a solid substrate, with the proviso that structure (I) has only one linking group selected from Y or Z to a solid substrate Q, as selective chelating or sequestering to remove at least one metal ion from aqueous solution. These dihydroxy compounds are useful to remove metal ions (e.g., Fe.sup.+3, from industrial waste water, human or mammalian blood or plasma, and the like.

    摘要翻译： 本发明涉及结构式（I）的2,3-二羟基对苯二甲酰胺的用途：其中A选自氢或连接于固体基质Q的有机连接基团Y，R 1独立地为 选自具有1至20个碳原子的烷基或具有6至14个碳原子的芳基，R 2选自R 1或与固体基质结合的有机连接基团Z，条件是结构（I）仅具有一个 选自Y或Z的连接基团作为选择性螯合或螯合以从水溶液中除去至少一种金属离子。 这些二羟基化合物可用于从工业废水，人或哺乳动物血液或血浆等中除去金属离子（例如Fe + 3）。

    2,3-Dihydroxybenzoic acid amides of tetraazaalkanes and tetaaza cycloalkanes
    23.
    发明授权
    2,3-Dihydroxybenzoic acid amides of tetraazaalkanes and tetaaza cycloalkanes 失效
    四氮杂烷烃和四氮杂环烷烃的2,3-二羟基苯甲酸酰胺

    公开(公告)号：US4181654A

    公开(公告)日：1980-01-01

    申请号：US927234

    申请日：1978-07-24

    申请人： Frederick L. Weitl ,  Kenneth N. Raymond

    发明人： Frederick L. Weitl ,  Kenneth N. Raymond

    IPC分类号： C07D257/02 ,  C07C103/87

    CPC分类号： C07D257/02

    摘要： A compound of the formula: ##STR1## wherein X is hydrogen or a conventional electron-withdrawing group, particularly --SO.sub.3 H or a salt thereof; n is 2, 3, or 4; m is 2, 3, or 4; and p is 2 or 3. The present compounds are useful as specific sequestering agents for actinide (IV) ions. Also described is a method for the 2,3-dihydroxybenzamidation of azaalkanes.

    摘要翻译： 下式的化合物：其中X是氢或常规吸电子基团，特别是-SO 3 H或其盐; n为2,3或4; m为2,3或4; 并且p为2或3.本发明化合物可用作锕系元素（IV）离子的特定螯合剂。 还描述了氮杂烷烃的2,3-二羟基苯甲酰胺化方法。

    Aromatic triamide-lanthanide complexes
    24.
    发明授权
    Aromatic triamide-lanthanide complexes 有权
    芳香族三酰胺 - 镧系元素络合物

    公开(公告)号：US08551453B2

    公开(公告)日：2013-10-08

    申请号：US10585178

    申请日：2004-12-29

    申请人： Kenneth N. Raymond ,  Stephane Petoud ,  Jide Xu

    发明人： Kenneth N. Raymond ,  Stephane Petoud ,  Jide Xu

    IPC分类号： A61K49/00

    CPC分类号： C07C235/60 ,  C07B2200/11 ,  C07C271/20 ,  C07D277/16 ,  C12Q1/37 ,  G01N33/533 ,  G01N33/542 ,  G01N33/582

    摘要： The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

    摘要翻译： 本发明提供了包含镧系元素的金属离子的发光镧系元素金属螯合物和包含至少一个邻苯二甲酰亚胺基部分的络合剂。 还提供了掺入本发明的邻苯二甲酰氨基配体的探针和利用本发明配体的方法和包含本发明配体的探针。

    Luminescent macrocyclic lanthanide complexes
    25.
    发明授权
    Luminescent macrocyclic lanthanide complexes 有权
    发光大环镧系元素络合物

    公开(公告)号：US08173800B2

    公开(公告)日：2012-05-08

    申请号：US11839509

    申请日：2007-08-15

    申请人： Kenneth N. Raymond ,  Todd M. Corneillie ,  Jide Xu

    发明人： Kenneth N. Raymond ,  Todd M. Corneillie ,  Jide Xu

    IPC分类号： C07B47/00 ,  C07D487/22 ,  C07K16/00 ,  C12Q1/37

    CPC分类号： G01N33/582 ,  G01N2458/40

    摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

    摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内掺入羟基间苯二酰胺部分，其特征在于与各种多肽例如抗体和蛋白质以及高动力学稳定性令人惊奇的低非特异性结合。 这些特征将它们与已知的开放结构的配体区分开来。

    LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES
    27.
    发明申请
    LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES 有权

    公开(公告)号：US20080213917A1

    公开(公告)日：2008-09-04

    申请号：US11839509

    申请日：2007-08-15

    申请人： Kenneth N. Raymond ,  Todd M. Corneillie ,  Jide Xu

    发明人： Kenneth N. Raymond ,  Todd M. Corneillie ,  Jide Xu

    IPC分类号： G01N33/566 ,  C07K16/00 ,  C07K14/00 ,  C07D487/18 ,  G01N21/76 ,  C08F210/02 ,  C07K2/00 ,  C07H21/00

    CPC分类号： G01N33/582 ,  G01N2458/40

    摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

    摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内掺入羟基间苯二酰胺部分，其特征在于与各种多肽例如抗体和蛋白质以及高动力学稳定性令人惊奇的低非特异性结合。 这些特征将它们与已知的开放结构的配体区分开来。

    Polycatecholamide chelating agents
    29.
    发明授权
    Polycatecholamide chelating agents 失效
    聚儿茶酚胺螯合剂

    公开(公告)号：US4442305A

    公开(公告)日：1984-04-10

    申请号：US295512

    申请日：1981-08-24

    申请人： Frederick L. Weitl ,  Kenneth N. Raymond

    发明人： Frederick L. Weitl ,  Kenneth N. Raymond

    IPC分类号： C07C65/03 ,  C07C101/72

    CPC分类号： C07C65/03 ,  Y10S514/836

    摘要： Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. The compounds have the formula ##STR1## Polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO.sub.3 H, SO.sub.3 M, NO.sub.2, CO.sub.2 H or CO.sub.2 M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr.sub.3 or BCl.sub.3 in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated.

    摘要翻译： 描述了可用于体外或体内螯合的新型聚苯甲酰胺化合物。 所述化合物具有下式：将多胺与未被取代或被SO 3 H，SO 3 M，NO 2，CO 2 H或CO 2 M取代的2,3-二甲氧基苯甲酰氯反应，根据需要，在惰性溶剂中与多胺反应，然后用BBr 3或BCl 3脱甲基 惰性溶剂。 当需要在末端N上对称取代的化合物时，首先通过与醛或酮反应将多胺还原烷基化，并将所得希夫碱氢化。

    In vitro removal of actinide (IV) ions
    30.
    发明授权
    In vitro removal of actinide (IV) ions 失效
    体外去除锕系元素（Ⅳ）离子

    公开(公告)号：US4309305A

    公开(公告)日：1982-01-05

    申请号：US64596

    申请日：1979-08-07

    申请人： Frederick L. Weitl ,  Kenneth N. Raymond

    发明人： Frederick L. Weitl ,  Kenneth N. Raymond

    IPC分类号： C07D257/02 ,  G21F9/04

    CPC分类号： C07D257/02

    摘要： A compound of the formula: ##STR1## wherein X is hydrogen or a conventional electron-withdrawing group, particularly --SO.sub.3 H or a salt thereof; n is 2, 3, or 4; m is 2, 3, or 4; and p is 2 or 3. The present compounds are useful as specific sequestering agents for actinide (IV) ions. Also described is a method for the 2,3-dihydroxybenzamidation of azaalkanes.

    摘要翻译： 下式的化合物：其中X是氢或常规吸电子基团，特别是-SO 3 H或其盐; n为2,3或4; m为2,3或4; 并且p为2或3.本发明化合物可用作锕系元素（IV）离子的特定螯合剂。 还描述了氮杂烷烃的2,3-二羟基苯甲酰胺化方法。