公开(公告)号：US10987295B2

公开(公告)日：2021-04-27

申请号：US16908754

申请日：2020-06-23

申请人： College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation

发明人： Ji-Hyung Chung ,  Da-Yoon Chung

IPC分类号： A61K8/64 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61Q19/00 ,  A61Q19/08 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  A61K9/00

摘要： Provided is a novel peptide and a cosmetic composition for inhibiting a skin-aging or a skin-wrinkle formation including the same. The peptide has activities for facilitating the bindings between keratinocytes; and increasing the expressions of junction proteins significantly.

公开(公告)号：US20210040056A1

公开(公告)日：2021-02-11

申请号：US16967797

申请日：2019-02-08

申请人： SUNGKWANG MEDICAL FOUNDATION ,  CHA University Industry-Academic Cooperation Foundation

发明人： David Tae Aug KIM ,  A-Ram KIM ,  Young-Ger SUH ,  Jaehoon SIM

IPC分类号： C07D307/33

摘要： The present disclosure relates to a novel method for synthesizing DHPV, and more particularly, to a novel method for synthesizing DHPV (5-(3′,4′-dihydroxyphenyl)-γ-valerolactone)) which is a major metabolite of cacao. This method has the advantage of not only facilitating a large-scale synthesis by a new synthesis method that can overcome existing defects, but also making it easy to select antioxidants and isomers exhibiting anti-aging bioactivities. Therefore, it is effective in enabling mass production of DHPV having high value as a functional material for cosmetics and pharmaceuticals in a simple and economical manner.

公开(公告)号：US10729635B2

公开(公告)日：2020-08-04

申请号：US16345888

申请日：2017-10-30

申请人： College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation

发明人： Ji-Hyung Chung ,  Da-Yoon Chung

IPC分类号： A61K8/64 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61Q19/08 ,  A61Q19/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  A61K9/00

摘要： Provided is a novel peptide and a cosmetic composition for inhibiting a skin-aging or a skin-wrinkle formation including the same. The peptide has activities for facilitating the bindings between keratinocytes; and increasing the expressions of junction proteins significantly.

公开(公告)号：US10478392B2

公开(公告)日：2019-11-19

申请号：US15771222

申请日：2016-10-27

申请人： College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation

发明人： Ji-Hyung Chung

IPC分类号： A61K8/64 ,  C07K7/08 ,  A61Q19/08

摘要： Provided herein is a peptide, a cosmetic composition comprising the same, and a method for inhibiting skin-aging or skin-wrinkle formation using the same, the peptide having activities for facilitating the bindings between keratinocytes; and increasing the expressions of junction proteins.

公开(公告)号：US10280402B2

公开(公告)日：2019-05-07

申请号：US15328628

申请日：2015-08-06

申请人： College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation ,  INSTITUTE FOR BASIC SCIENCE

发明人： Jin Soo Kim ,  Dong Youn Hwang

IPC分类号： C12N5/074 ,  C12Q1/6881 ,  C12N5/0735 ,  C07K14/74 ,  C12N5/073

摘要： The present invention relates to a method for producing immune-compatible cells or a cell population which comprises a step of editing one or two alleles of one or more immune-compatible antigen genes by gene deletion or modification in an isolated cell comprising at least one of the immune-compatible antigen genes selected from HLA (human leukocyte antigen)-A, HLA-B and HLA-DR, to immune-compatible cells produced by the method, and to a cell population comprising the immune-compatible cells produced by the method.

公开(公告)号：US20180325794A1

公开(公告)日：2018-11-15

申请号：US15771222

申请日：2016-10-27

申请人： College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation

发明人： Ji-Hyung CHUNG

IPC分类号： A61K8/64 ,  A61Q19/08

CPC分类号： A61K8/64 ,  A61Q19/08 ,  C07K7/08

摘要： Provided herein is a peptide, a cosmetic composition comprising the same, and a method for inhibiting skin-aging or skin-wrinkle formation using the same, the peptide having activities for facilitating the bindings between keratinocytes; and increasing the expressions of junction proteins.

公开(公告)号：US20240006031A1

公开(公告)日：2024-01-04

申请号：US18254103

申请日：2021-10-25

申请人： CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Hea-Young CHO ,  Go-Wun CHOI ,  Eun-Jeong CHOI ,  Ju Hee KIM ,  Dong Wook KANG

IPC分类号： G16C20/30

CPC分类号： G16C20/30

摘要： One aspect provides a physiologically based pharmacokinetic core model which may be commonly applied to two or more compounds that share the same core structure, and a method of constructing the physiologically based pharmacokinetic core model. According to the physiologically based pharmacokinetic core model and the method of constructing the physiologically based pharmacokinetic core model, there is the effect of conducting exposure evaluation simply only by deriving a distribution coefficient, without constructing a separate PBPK model for each individual compound.

公开(公告)号：US20230332079A1

公开(公告)日：2023-10-19

申请号：US18003067

申请日：2021-06-23

申请人： CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  SUNGKWANG MEDICAL FOUNDATION

发明人： Youn Jung KANG ,  Jung Ho AHN ,  Min Ji YOON ,  Hwi Jae CHA ,  Seon Hwa HONG

IPC分类号： C12M3/00 ,  C12M3/06

CPC分类号： C12M21/08 ,  C12M23/16

摘要： The present disclosure relates to a biomimetic chip for three-dimensionally simulating an endometrium, and an endometrium simulating method using the biomimetic chip. The biomimetic chip according to an embodiment of the present disclosure is a three-dimensional biomimetic chip including a plate, a plurality of chambers, and a plurality of posts, which are arranged between the plurality of chambers, wherein the plurality of chambers include channels in which different cells are cultured, are arranged on the plate to be parallel to each other in one direction, and are arranged adjacent to each other such that at least some sections communicate with each other.

公开(公告)号：US11435368B2

公开(公告)日：2022-09-06

申请号：US16206080

申请日：2018-11-30

申请人： CHA University Industry-Academic Cooperation Foundation ,  The General Hospital Corporation

发明人： Ji Sook Moon ,  Hak Ho Lee ,  Ala Jo ,  Jae Hyun Park ,  Ji Min Park ,  Chul Woo Lim ,  Yu Ri Choi

IPC分类号： G01N33/92

摘要： Provided are a biomarker for diagnosing of the level of senescence, a composition and kit for diagnosing of the level of senescence to detect the biomarker, and a method of diagnosing the same. According to the composition and kit for the diagnosis of the level of senescence and the method of diagnosing senescence, the level of senescence of a subject is easily diagnosed, the health conditions of the subject are monitored, and a senescence-associated disease is prevented or diagnosed.

公开(公告)号：US20220194998A1

公开(公告)日：2022-06-23

申请号：US17310517

申请日：2020-02-06

申请人： CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Kwang-Hyun BAEK ,  Ji-Hye CHOI

IPC分类号： C07K14/47

摘要： The present invention provides an Oct-3/4 protein variant wherein lysine at position 156; lysine at position 286; or lysines at positions 156 and 286 in the Oct-3/4 protein is (are) substituted with arginine. The Oct-3/4 protein variant according to the present invention can inhibit a protein degradation mechanism through ubiquitination, and shows a higher half-life, compared to the wild-type Oct-3/4, thereby exhibiting high stability.