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    NOVEL EGFR MODULATORS AND USES THEREOF
    22.
    发明申请
    NOVEL EGFR MODULATORS AND USES THEREOF 有权
    新型EGFR调节剂及其用途

    公开(公告)号：US20140038940A1

    公开(公告)日：2014-02-06

    申请号：US13843554

    申请日：2013-03-15

    Applicant: ACEA BIOSCIENCES INC.

    Inventor： Xiao XU ,  Xiaobo Wang ,  Long Mao ,  Li Zhao ,  Biao Xi

    IPC: A61K31/519 ,  C07D487/04

    CPC classification number: A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  A61K2300/00

    Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

    Abstract translation: 本发明涉及某些吡咯并嘧啶衍生物，含有它们的药物组合物及其使用方法，包括治疗肿瘤的方法和与激酶失调相关的相关疾病（如EGFR（包括HER），Alk，PDGFR），但是 途径。

    Optical detection system for flow cytometer, flow cytometer system and methods of use
    28.
    发明授权
    Optical detection system for flow cytometer, flow cytometer system and methods of use 有权

    公开(公告)号：US10261080B2

    公开(公告)日：2019-04-16

    申请号：US15650896

    申请日：2017-07-15

    Applicant: ACEA Biosciences, Inc.

    Inventor： Nan Li ,  Lingbo Kong ,  Jian Wu ,  Ting Cheng ,  Yangde Qin ,  Xiaobo Wang

    IPC: G01N33/569 ,  G01N15/14 ,  G01N15/10

    Abstract: An optical engine its use in a bench top flow cytometer, the optical engine having a set of lasers, each focused horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same excitation plane of a flow cell, a set of optics that separate fluorescence of a same wavelength range into different locations in a focal plane of collection optics according to the different lasers by which the fluorescent light is excited; and a detector that selectively detects light from the different locations thereby distinguishing between fluorescence emitted within the same wavelength range as excited by the different lasers.

    Optical engine for flow cytometer, flow cytometer system and methods of use
    29.
    发明授权
    Optical engine for flow cytometer, flow cytometer system and methods of use 有权

    公开(公告)号：US10234392B2

    公开(公告)日：2019-03-19

    申请号：US15416976

    申请日：2017-01-26

    Applicant: ACEA Biosciences, Inc.

    Inventor： Nan Li ,  Ye Chen ,  Hyunsun Chung ,  Zengqiang Li ,  Xiaobo Wang

    IPC: G01N21/64 ,  G01N33/569 ,  G01N15/14 ,  G01N15/10

    Abstract: An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.

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