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公开(公告)号：US20240238362A1
公开(公告)日：2024-07-18
申请号：US17917618
申请日：2021-04-06
发明人： Youngwook Won , David Bull , Minjin Jung , Angela Kim
摘要： Provided herein are compositions and methods for treating obesity. In particular, provided herein are anti-obesity peptides and uses of such peptides in the treatment and prevention of obesity and related medical conditions. Further disclosed are the sequences of anti-obesity peptides, wherein the peptides can be cyclized via the addition of a cysteine to each end of the said peptides.
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公开(公告)号：US20240235143A1
公开(公告)日：2024-07-11
申请号：US18150723
申请日：2023-01-05
发明人： Yushi Kaneda , Lloyd J. LaComb, JR. , Khanh Kieu
CPC分类号： H01S3/0092 , G02F1/3534 , G02F1/354 , G02F1/3544 , G02F1/3551 , H01S3/0057 , H01S3/067
摘要： Laser sources of the present invention allow for the efficient generation of harmonic frequencies from broadband sources. Over-compression and under-compression of a split signal result in two beams chirped in opposite directions. These two beams may be combined in a non-linear crystal to generate a narrow-band harmonic signal from a broadband source.
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23.发明公开公开(公告)号：US20240219301A1
公开(公告)日：2024-07-04
申请号：US18557478
申请日：2022-04-27
CPC分类号： G01N21/59 , G01N21/55 , G01N2021/1725
摘要： Methodology for optical switching and/or coding of information with attosecond time resolution and, in particular, binary encoding of data based on modulation of reflectivity or transmissivity of a target non-electrically-conducting material system in a strong light field.
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公开(公告)号：US20240166598A1
公开(公告)日：2024-05-23
申请号：US18264109
申请日：2022-02-02
申请人： Arizona Board of Regents on Behalf of the University of Arizona , The Board of Trustees of the University of Illinois
发明人： Gregory R. Thatcher , Zhengnan Shen , Rui Xiong , Kiira Ratia , Lijun Rong , Laura Cooper
IPC分类号： C07D205/04 , A61K39/215 , A61K39/39 , A61K45/06 , A61P31/14 , C07C211/49 , C07C237/30 , C07D209/08 , C07D209/14 , C07D211/58 , C07D211/62 , C07D213/81 , C07D215/12 , C07D333/20 , C07D333/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07H19/067
CPC分类号： C07D205/04 , A61K39/215 , A61K39/39 , A61K45/06 , A61P31/14 , C07C211/49 , C07C237/30 , C07D209/08 , C07D209/14 , C07D211/58 , C07D211/62 , C07D213/81 , C07D215/12 , C07D333/20 , C07D333/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07H19/067
摘要： Provided herein are PLpro inhibitors and methods of treating and/or preventing an infection caused by a coronavirus by administration of one or more of said PLpro inhibitors to a subject in need thereof, as well as pharmaceutical formulations and kits for use in these methods.
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25.发明公开公开(公告)号：US20240151984A1
公开(公告)日：2024-05-09
申请号：US18280830
申请日：2022-03-03
摘要： Integral imaging based light field displays using time-multiplexing schemes.
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公开(公告)号：US11960815B2
公开(公告)日：2024-04-16
申请号：US18092485
申请日：2023-01-03
发明人： Wolfgang Fink
IPC分类号： G06F30/398 , G06F30/327 , G06F30/33 , G06F30/394 , G06F111/06 , G06F111/08 , G06F119/06
CPC分类号： G06F30/398 , G06F30/327 , G06F30/33 , G06F30/394 , G06F2111/06 , G06F2111/08 , G06F2119/06
摘要： Various examples are provided related to automated chip design, such as a pareto-optimization framework for automated network-on-chip design. In one example, a method for network-on-chip (NoC) design includes determining network performance for a defined NoC configuration comprising a plurality of n routers interconnected through a plurality of intermediate links; comparing the network performance of the defined NoC configuration to at least one performance objective; and determining, in response to the comparison, a revised NoC configuration based upon iterative optimization of the at least one performance objective through adjustment of link allocation between the plurality of n routers. In another example, a method comprises determining a revised NoC configuration based upon iterative optimization of at least one performance objective through adjustment of a first number of routers to obtain a second number of routers and through adjustment of link allocation between the second number of routers.
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公开(公告)号：US20240101604A1
公开(公告)日：2024-03-28
申请号：US17583956
申请日：2022-01-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Theresa Hwang , Amy E. Keating , Meucci Ilunga , Sara Parker , Ghassan Mouneimne , Samantha Hill
CPC分类号： C07K7/08 , A61P35/00 , C07K14/001 , C07K2319/01
摘要： Peptides that selectively bind ENAH (MENA) are described. The peptides are useful for treating certain cancers, such as triple negative breast cancer and for reducing resistance to taxane therapy.
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公开(公告)号：US11931239B2
公开(公告)日：2024-03-19
申请号：US16973571
申请日：2019-08-01
发明人： Charles T. Hennemeyer , Adam Gold
IPC分类号： A61F2/06
CPC分类号： A61F2/064 , A61F2002/061
摘要： Collapsible branched anastomosis devices allow for the formation of percutaneous vascular anastomoses using a Seldinger wire technique. This minimally invasive approach eliminates the need for a large surgical incision and also avoids the use of time consuming hand-suturing. The devices collapse to a fraction of their expanded volume and are configured to fit within a delivery sheath for over the wire delivery through a small incision in a blood vessel.
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29.发明授权公开(公告)号：US11922275B2
公开(公告)日：2024-03-05
申请号：US17351873
申请日：2021-06-18
申请人： Arizona Board of Regents on Behalf of the University of Arizona , NICOLAUS COPERNICUS UNIVERSITY IN TORÚN
IPC分类号： G06F30/398 , G06N10/00
CPC分类号： G06N10/00
摘要： A method for determining a perturbation energy of a quantum state of a many-body system includes constructing a wave function that approximates the quantum state by adjusting parameters of the wave function to minimize an expectation value of a zeroth-order Hamiltonian. The zeroth-order Hamiltonian explicitly depends on a finite mass of each of a plurality of interacting quantum particles that form the many-body system, the quantum state has a non-zero total angular momentum, the wave function is a linear combination of explicitly correlated Gaussian basis functions, and each of the explicitly correlated Gaussian basis functions includes a preexponential angular factor. The perturbation energy is calculated from the wave function and a perturbation Hamiltonian that explicitly depends on the finite mass of each of the plurality of interacting quantum particles. The perturbation energy may be added to the minimized expectation value to obtain a total energy of the quantum state.
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公开(公告)号：US11921285B2
公开(公告)日：2024-03-05
申请号：US17594457
申请日：2020-04-19
发明人： John Koshel , Emma Landsiedel
CPC分类号： G02B27/0075 , G01B9/02 , G01B11/2441 , G01J3/26 , G01J3/45 , H04N23/56 , H04N23/67 , H04N23/959
摘要： Method and system for on-chip processing to obtain an EDOF image combines interferometry and imaging so the two operations do not interfere with one another but, rather, work together to create an in-focus, true color image of a three-dimensional object. This image has no significant artifacts and requires only limited processing. In addition, a coarse depth map is created in the process which may also be helpful in subsequent usage of the acquired image. A CMOS pixel-array sensor includes circuitry to implement processing at the pixel level.
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