公开(公告)号：US20040012856A1

公开(公告)日：2004-01-22

申请号：US10257198

申请日：2003-06-04

Inventor： Mikhail A. Gutin

IPC: G02B005/18

CPC classification number: G02B6/2931 ,  G01J3/02 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/1804 ,  G02B5/1828 ,  G02B6/29313 ,  G02B6/29314 ,  G02B6/2938 ,  G02B6/29395 ,  G02B26/0808

Abstract: The present invention provides an improvement in a wavelength division multiplexer and/or a dense wavelength division multiplexer (WDM/DWDM) by incorporating an electronically reconfigurable diffraction grating (108). The introduction of the electronically reconfigurable diffraction grating (108), which is typically fabricated using MEMS (microelectromechanical systems) technology, improves the compact design, durability, and dynamic functionality of the WDM/DWDM system.

Abstract translation: 本发明通过结合电子可重构衍射光栅（108）来提供波分复用器和/或密集波分多路复用器（WDM / DWDM）的改进。 通常使用MEMS（微机电系统）技术制造的电子可重构衍射光栅（108）的引入改善了WDM / DWDM系统的紧凑设计，耐用性和动态功能。

公开(公告)号：US06678044B2

公开(公告)日：2004-01-13

申请号：US09907032

申请日：2001-07-17

Applicant: Tsutomu Kaneko

Inventor： Tsutomu Kaneko

IPC: G01J318

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/0286

Abstract: Plane diffraction grating 13 is formed of a material having an appropriate linear expansion coefficient and a variation in the wavelength of the reflected light from concave mirror 14 on account of thermal expansion or shrinkage of members other than plane diffraction grating 13 is cancelled out or reduced by a variation in the wavelength of the reflected light from concave mirror 14 on account of thermal expansion or shrinkage of plane diffraction grating 13. The same principle is used to deal with the effect on the wavelength of the diffracted light that may be caused by changes in the layout of individual members on account of thermal expansion or shrinkage of substrate 10a that fix them.

Abstract translation: 平面衍射光栅13由具有适当的线膨胀系数的材料形成，并且由于除了平面衍射光栅13之外的构件的热膨胀或收缩，来自凹面镜14的反射光的波长的变化被抵消或减少 考虑到平面衍射光栅13的热膨胀或收缩，来自凹面镜14的反射光的波长的变化。使用相同的原理来处理由于衍射光的波长的影响，这可能是由于 考虑到固定它们的基板10a的热膨胀或收缩的各个构件的布局。

公开(公告)号：US20030202956A1

公开(公告)日：2003-10-30

申请号：US10435203

申请日：2003-05-12

Applicant: Closure Medical Corporation

Inventor： Jeffrey G. Clark ,  Jeffrey C. Leung

IPC: A61L017/00 ,  A61K031/785

CPC classification number: A61L24/06 ,  A61B5/14532 ,  A61B5/1455 ,  A61L24/0021 ,  C09J4/00 ,  G01J3/1804 ,  C08L35/04 ,  C08F222/32

Abstract: A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt. to 15 wt. % of the composition; and (C) at least one acidic stabilizing agent having a pKa ionization constant of from about 1 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) holding damaged tissue edges together to form abutted tissue surfaces; (b) applying to the abutted tissue surfaces an excessive amount of a composition containing 1) at least one monomer, which forms a medically acceptable biodegradable polymer, 2) at least one plasticizing agent; and 3) at least one acidic stabilizing agent; and (c) maintaining the surfaces in contact until the composition polymerizes to form a thick film of polymerized composition bridging the abutted tissue surfaces.

Abstract translation: 生物相容性单体组合物包括：（A）至少一种形成医学上可接受的聚合物的单体; （B）组合物中存在的至少一种增塑剂的量为0.5wt。 至15重量％ ％的组成; 和（C）至少一种具有约1至约7的pKa电离常数的酸性稳定剂。该组合物可以应用于各种材料，并且特别适合作为体内组织粘合剂。 在体内将两个表面（例如身体组织）接合在一起的方法包括（a）将损伤的组织边缘保持在一起以形成邻接的组织表面; （b）向邻接的组织表面施加过量的组合物，其含有1）至少一种形成医学上可接受的生物可降解聚合物的单体，2）至少一种增塑剂; 和3）至少一种酸性稳定剂; 和（c）保持表面接触直到组合物聚合以形成桥接邻接组织表面的聚合组合物的厚膜。

公开(公告)号：US20030160961A1

公开(公告)日：2003-08-28

申请号：US10316707

申请日：2002-12-10

Applicant: Molecular Devices Corporation

Inventor： Dean Hafeman ,  Calvin Y. Chow

IPC: G01N021/59 ,  G01N021/00

CPC classification number: G01J3/08 ,  G01J3/1804 ,  G01N21/253 ,  G01N21/31 ,  G01N21/314 ,  G01N21/6452

Abstract: Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical pathlength of liquid samples containing the solvent. This relationship is used to establish the optical pathlength for samples containing an unknown concentration of analyte but having similar solvent composition. Further disclosed are methods and devices for determining the concentration of analyte in such samples where both the optical pathlength and the concentration of analyte are unknown. The methods and devices rely on separately determining, at different wavelengths of light, light absorption by the solvent and light absorption by the analyte. Light absorption by the analyte, together with the optical pathlength so determined, is used to calculate the concentration of the analyte. Devices for carrying out the methods particularly advantageously include vertical-beam photometers containing samples disposed within the wells of multi-assay plates, wherein the photometer is able to monitor light absorption of each sample at multiple wavelengths, including in the visible or UV-visible region of the spectrum, as well as in the near-infrared region of the electromagnetic spectrum. Novel photometer devices are described which automatically determine the concentration of analytes in such multi-assay plates directly without employing a standard curve.

公开(公告)号：US20020126280A1

公开(公告)日：2002-09-12

申请号：US10011236

申请日：2001-10-19

Inventor： Thomas L. Mikes

IPC: G01J003/28

CPC classification number: G01J3/1838 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/1804 ,  G01J3/28 ,  G01J2003/2866 ,  G02B6/2931 ,  G02B6/29314 ,  G02B6/29395 ,  G02B6/29398

Abstract: A spectrum analyzer providing an integrated calibration function and for providing that calibration function automatically. The injection of light to be analyzed through a central aperture of a scanning grating onto a focusing reflector provides in combination four traversals of the space therebetween. The spectrometer thus is used to separate wavelength information spacially and receive it back at the same or adjacent aperture(s) to be analyzed by a processing system to establish the spectra for the incident light. The light is typically injected from and received back into optical fibers or other light carrying elements. Calibration light is also applied through the same or adjacent apertures in the grating from a known source and spectra such as Argon to use as a calibration reference by detecting the known spectra peaks and correlating it to grating scan angle. The same structure is also used as a telecommunications channel router by injecting light of multi-channel and thus broadband spectral content into the spectrometer through the central aperture(s) and angling the grating so that a selected channel or channels are reflected back after four passages of the spectral separator to output one or more optical fibers or other guides.

Abstract translation: 频谱分析仪提供集成校准功能，并自动提供校准功能。 通过扫描光栅的中心孔将待分析的光注入到聚焦反射器上，四者之间的空间组合四次。 因此，光谱仪用于空间分离波长信息并在相同或相邻孔径处接收，以便由处理系统分析以建立入射光的光谱。 光通常从光纤或其他轻载元件注入并接收回。 校准光也通过来自已知源和光谱（例如氩）的光栅中的相同或相邻孔径施加，以通过检测已知光谱峰值并将其与光栅扫描角度相关联来用作校准参考。 同样的结构也被用作通信信道路由器，它通过中心孔和多个通道将光通道注入光谱仪，从而使光纤通过四通道反射回所选择的通道 的光谱分离器以输出一个或多个光纤或其它引导件。

公开(公告)号：US06411382B1

公开(公告)日：2002-06-25

申请号：US09548581

申请日：2000-04-13

Applicant: Shigeki Nishina

Inventor： Shigeki Nishina

IPC: G01J318

CPC classification number: G01J3/1804

Abstract: The monochromator and the spectrometric method are disclosed wherein the measured beam converted into a parallel beam by a first collimator is diffracted by a plane diffraction grating, then the diffracted beam is returned so that the diffracted beam after the return is separated from that before the return along rulings of the plane diffraction grating, the diffracted beam is diffracted again by the plane diffraction grating, then the beam condensed by a second collimator is allowed to pass through an exit slit.

Abstract translation: 公开了单色仪和光谱测量方法，其中通过平面衍射光栅衍射由第一准直仪转换成平行光束的测量光束，然后衍射光束返回，使得返回之后的衍射光束与返回之前的衍射光束分离 沿着平面衍射光栅的排列，衍射光束再次被平面衍射光栅衍射，则允许由第二准直器聚焦的光束通过出射狭缝。

公开(公告)号：US20020044280A1

公开(公告)日：2002-04-18

申请号：US09972037

申请日：2001-10-09

Inventor： Adam Mark Weigold ,  Peter Graham Foster

IPC: G01J003/12 ,  G01J003/28

CPC classification number: G01J3/1804 ,  G01J3/06 ,  G01J2003/2866

Abstract: The invention provides a method and apparatus for determining the wavelength of a sample source of light, the apparatus having a reference light source of known wavelength, a collimator for collimating light from the sample source and from the reference source, a dispersing means for receiving and spatially dispersing collimated light from the collimator according to wavelength, focusing means for focusing dispersed light from the dispersing means, and a photodetector located in the focal plane of the focusing means and having an aperture for spatially selectively admitting light from the focusing means, and operable to provide a temporally calibratable output signal indicative of the wavelength of the selectively admitted light, wherein the apparatus is operable to scan the focused spatially dispersed beam across the aperture, and the photodetector output includes resolvable features corresponding to light from the reference source and sample source, whereby a time difference between the features is indicative of a wavelength difference between the light from the reference source and the sample source.

Abstract translation: 本发明提供了一种用于确定样品光源的波长的方法和装置，该装置具有已知波长的参考光源，用于准直来自样品源和参考源的光的准直器，用于接收和 根据波长对来自准直器的准直光进行空间分散，用于聚焦来自分散装置的分散光的聚焦装置，以及位于聚焦装置的焦平面中的光电检测器，并具有用于空间选择性地允许来自聚焦装置的光的孔， 以提供指示所选择的入射光的波长的可临时校准的输出信号，其中该装置可操作以扫过聚焦的空间分散的光束穿过孔，并且光电检测器输出包括对应于来自参考源和样品源的光的可分辨特征 ，由此之间的时间差 这些特征表示来自参考源的光和样品源之间的波长差。

公开(公告)号：US20020024015A1

公开(公告)日：2002-02-28

申请号：US09928501

申请日：2001-08-14

Inventor： Juergen Hoffmann ,  Werner Knebel

IPC: G21K007/00 ,  G01N023/00

CPC classification number: G02B21/16 ,  G01J3/0229 ,  G01J3/14 ,  G01J3/1804 ,  G01J2003/1213 ,  G21K7/00

Abstract: The present invention relates to a device and to a method for the excitation of fluorescent markers in multiphoton scanning microscopy, having at least one illumination beam path, a light source that produces the illumination light and at least one detection beam path for a detector, the objects to be studied being labelled with fluorescent markers. So as to avoid making it necessary to increase the illumination power of the light source in order to achieve an increase in the fluorescence photon yield, the device according to the invention and the method according to the invention are characterized in that at least one means that influences the spectral distribution/composition of the illumination light is provided for variably influencing the illumination light that excites the fluorescent markers, in particular during the illumination process.

Abstract translation: 本发明涉及一种用于激发多光子扫描显微镜中的荧光标记物的装置和方法，具有至少一个照明光束路径，产生照明光的光源和用于检测器的至少一个检测光束路径， 待研究的对象用荧光标记物标记。 为了避免增加光源的照明功率以实现荧光光子产量的增加，根据本发明的装置和根据本发明的方法的特征在于，至少有一种方法是 影响照明光的光谱分布/组成被提供用于可变地影响激发荧光标记的照明光，特别是在照明过程期间。

公开(公告)号：US20020008873A1

公开(公告)日：2002-01-24

申请号：US09907032

申请日：2001-07-17

Inventor： Tsutomu Kaneko

IPC: G01J003/18

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/0286

Abstract: Plane diffraction grating 13 is formed of a material having an appropriate linear expansion coefficient and a variation in the wavelength of the reflected light from concave mirror 14 on account of thermal expansion or shrinkage of members other than plane diffraction grating 13 is cancelled out or reduced by a variation in the wavelength of the reflected light from concave mirror 14 on account of thermal expansion or shrinkage of plane diffraction grating 13. The same principle is used to deal with the effect on the wavelength of the diffracted light that may be caused by changes in the layout of individual members on account of thermal expansion or shrinkage of substrate 10a that fix them.

Abstract translation: 平面衍射光栅13由具有适当的线膨胀系数的材料形成，并且由于除了平面衍射光栅13之外的构件的热膨胀或收缩，来自凹面镜14的反射光的波长的变化被抵消或减少 考虑到平面衍射光栅13的热膨胀或收缩，来自凹面镜14的反射光的波长的变化。使用相同的原理来处理由于衍射光的波长的影响，这可能是由于 考虑到固定它们的基板10a的热膨胀或收缩的各个构件的布局。

公开(公告)号：US06339472B1

公开(公告)日：2002-01-15

申请号：US09557750

申请日：2000-04-25

Applicant: Dean G. Hafeman ,  Calvin T. Chow

Inventor： Dean G. Hafeman ,  Calvin T. Chow

IPC: G01N2100

CPC classification number: G01J3/08 ,  G01J3/1804 ,  G01N21/253 ,  G01N21/31 ,  G01N21/314 ,  G01N21/6452

Abstract: Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical pathlength of liquid samples containing the solvent. This relationship is used to establish the optical pathlength for samples containing an unknown concentration of analyte but having similar solvent composition. Further disclosed are methods and devices for determining the concentration of analyte in such samples where both the optical pathlength and the concentration of analyte are unknown. The methods and devices rely on separately determining, at different wavelengths of light, light absorption by the solvent and light absorption by the analyte. Light absorption by the analyte, together with the optical pathlength so determined, is used to calculate the concentration of the analyte. Devices for carrying out the methods particularly advantageously include vertical-beam photometers containing samples disposed within the wells of multi-assay plates, wherein the photometer is able to monitor light absorption of each sample at multiple wavelengths, including in the visible or UV-visible region of the spectrum, as well as in the near-infrared region of the electromagnetic spectrum. Novel photometer devices are described which automatically determine the concentration of analytes in such multi-assay plates directly without employing a standard curve.

Abstract translation: 公开了用于确定含有溶解或悬浮在溶剂中的分析物的液体样品的光程长度的光度测定方法和装置。 所述方法和装置依赖于确定溶剂的光吸收性质和含有溶剂的液体样品的光程长度之间的关系。 该关系用于建立含有未知浓度的分析物但具有相似溶剂组成的样品的光程。 进一步公开了用于确定样品中分析物浓度的方法和装置，其中光程长和分析物浓度都是未知的。 方法和装置依赖于在不同波长的光下分别确定溶剂的光吸收和被分析物的光吸收。 被分析物的光吸收以及如此确定的光程长度被用于计算分析物的浓度。 用于实施方法的装置特别有利地包括垂直光束光度计，其包含设置在多测定板的孔内的样品，其中光度计能够监测包括在可见光或可见光区域中的多个波长的每个样品的光吸收 的光谱，以及在电磁光谱的近红外区域。 描述了新的光度计装置，其直接在不使用标准曲线的情况下自动确定这种多测定板中的分析物的浓度。