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272 条记录 (耗时 0.052 秒)

    THERAPEUTIC PEPTIDES
    15.
    发明申请
    THERAPEUTIC PEPTIDES 有权
    治疗肽

    公开(公告)号：US20130035296A1

    公开(公告)日：2013-02-07

    申请号：US13505625

    申请日：2010-11-02

    申请人： Morten Strom ,  Terkel Hansen ,  Martina Havelkova ,  Veronika Torfoss

    发明人： Morten Strom ,  Terkel Hansen ,  Martina Havelkova ,  Veronika Torfoss

    IPC分类号： C07C237/20 ,  A61K31/16 ,  C07C237/14 ,  A61K31/165 ,  A61P35/00 ,  A61K38/08 ,  A61K31/495 ,  C07D241/04 ,  A61P31/04 ,  A61P35/04 ,  C07C237/10 ,  C07K7/06

    CPC分类号： C07K5/0202 ,  A61K38/00 ,  C07C237/20 ,  C07C2601/14 ,  C07D209/20 ,  C07D295/185 ,  C07K7/02

    摘要： The present invention provides a peptide, peptidomimetic or amino acid derivative having a net positive charge of at least +2 and incorporating a disubstituted β amino acid, each of the substituting groups in the β amino acid, which may be the same or different, comprises at least (7) non-hydrogen atoms, is lipophilic and has at least one cyclic group, one or more cyclic groups within a substituting group may be linked or fused to one or more cyclic groups within the other substituting group and where cyclic groups are fused in this way the combined total number of non-hydrogen atoms for the two substituting groups is at least (12), for use as a cytolytic therapeutic agent; as well as non therapeutic uses of these molecules and certain defined novel compounds from within this definition.

    摘要翻译： 本发明提供具有至少+2的净正电荷并掺入二取代的bgr的肽，拟肽或氨基酸衍生物。 氨基酸，“bgr”中的每个取代基 氨基酸可以相同或不同，包含至少（7）个非氢原子，是亲脂性的并且具有至少一个环状基团，取代基团中的一个或多个环状基团可以连接或稠合至一个或多个 在另一个取代基中的环状基团，其中环状基团以这种方式融合，两个取代基团的非氢原子的合并总数至少为（12），用作细胞溶解治疗剂; 以及这些分子的非治疗用途和来自该定义内的某些定义的新化合物。

    TRANSFECTION REAGENTS
    16.
    发明申请
    TRANSFECTION REAGENTS 有权

    公开(公告)号：US20120238747A1

    公开(公告)日：2012-09-20

    申请号：US13420091

    申请日：2012-03-14

    申请人： Yongliang CHU ,  Malek Masoud ,  Gulilat Gebeyehu

    发明人： Yongliang CHU ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC分类号： C07C211/63 ,  C07D273/08 ,  C07C215/18 ,  C07C237/10 ,  C07J1/00

    CPC分类号： A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    摘要： Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L′-X2—Z or —Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; U is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Transfection reagents
    18.
    发明申请
    Transfection reagents 有权

    公开(公告)号：US20050260597A1

    公开(公告)日：2005-11-24

    申请号：US10629522

    申请日：2003-07-28

    申请人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    发明人： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/22 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C215/18 ,  C07C217/08 ,  C07C229/26 ,  C07C237/10 ,  C07C279/08 ,  C07D211/26 ,  C07D213/38 ,  C07D241/12 ,  C07D273/08 ,  C07D291/02 ,  C12N5/10 ,  C12Q1/68 ,  C07F9/06 ,  C07F9/28

    CPC分类号： A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    摘要： Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L′-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.