公开(公告)号：US20150104408A1

公开(公告)日：2015-04-16

申请号：US14552664

申请日：2014-11-25

申请人： Arrowhead Madison Inc.

发明人： Darren H. Wakefield ,  Nicholas A. Rossi ,  David B. Rozema ,  Lauren J. Almeida ,  Anthony L. Perillo-Nicholas

IPC分类号： A61K47/48 ,  C08F220/34 ,  A61K47/32

CPC分类号： B25F5/02 ,  A61K47/32 ,  A61K47/58 ,  B23D45/16 ,  B23Q13/00 ,  B27B5/29 ,  B27B9/00 ,  C08F220/00 ,  C08F220/34 ,  C08F220/36 ,  C08F220/18

摘要： The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.

摘要翻译： 本发明涉及膜活性聚（丙烯酸酯）聚合物和用于在体内靶向递送RNA干扰（RNAi）多核苷酸细胞的组合物。 RNAi多核苷酸与聚（丙烯酸酯）聚合物缀合，并且可逆地修饰聚合物以实现体内靶向递送。 聚（丙烯酸酯）的膜活性提供了从细胞外部到细胞内的RNAi多核苷酸的移动。 可逆修饰提供生理反应。

公开(公告)号：US08898913B1

公开(公告)日：2014-12-02

申请号：US14306358

申请日：2014-06-17

申请人： Michael J. Lones

发明人： Michael J. Lones

IPC分类号： B23D47/02

CPC分类号： B23D47/02 ,  B23D45/16 ,  B28D1/04

摘要： A supporting and stabilizing shoe used with a masonry circular power saw. A shoe frame rigidly mounts to the saw's motor frame. A plate that is preferably substantially planar and bifurcated to form two substantially co-planar members with a gap therebetween pivotably mounts to the shoe frame. A spring biases the plate away from the blade, but can be overcome, and an adjustment knob tightens the plate in position relative to the blade. This provides for depth adjustment for the blade and keeps the blade at a desired angle, such as ninety degrees, to the workpiece surface. The plate extends longitudinally from the motor frame beneath the drive mechanism and the blade of the saw to provide a stable surface upon which the saw can rest during use or storage.

摘要翻译： 一种支撑和稳定鞋，与砖石圆形电锯一起使用。 鞋框刚性地安装到锯的电机框架上。 优选地，基本上平面且分叉以形成两个基本上共面的构件，其间具有间隙的板可枢转地安装到鞋框架上的板。 弹簧将板偏离刀片，但可以克服，并且调节旋钮将板相对于刀片紧固在适当位置。 这为刀片提供了深度调整，并将刀片保持在与工件表面相似的所需角度，如九十度。 该板从驱动机构下方的马达框架和锯片的叶片纵向延伸，以提供稳定的表面，锯在其上可以在使用或储存期间保持其上。

公开(公告)号：US08857421B2

公开(公告)日：2014-10-14

申请号：US13033999

申请日：2011-02-24

申请人： Masaki Kondo ,  Tomonobu Nashimoto

发明人： Masaki Kondo ,  Tomonobu Nashimoto

IPC分类号： B23D45/16 ,  B24B55/05 ,  B23D59/00

CPC分类号： B23D45/16 ,  B23D59/006

摘要： A handheld engine-driven cutter is provided with a disk blade and a main body that drives the disk blade by an engine. A guard surface for repelling chips of a workpiece that scatter from the disk blade to below the main body is formed on the main body. The guard surface has an asymmetric shape with respect to a boundary that is a rotating plane of the disk blade.

摘要翻译： 手持式发动机驱动的切割器具有盘片和通过发动机驱动盘片的主体。 在主体上形成有用于将从盘片散射到工件主体的工件的芯片排斥的防护面。 防护表面相对于作为盘片的旋转平面的边界具有不对称的形状。

公开(公告)号：US20140245622A1

公开(公告)日：2014-09-04

申请号：US14252410

申请日：2014-04-14

申请人： Black & Decker Inc.

发明人： Robert S. Gehret

IPC分类号： B23D45/16

CPC分类号： B23D45/16 ,  B23D47/12 ,  B23D47/123 ,  B23D47/126 ,  B27B9/02

摘要： A circular saw includes a housing assembly and a drive motor assembly coupled to the housing assembly. An output member is driven by the drive motor assembly. A shoe is adjustably mounted to the housing assembly. A circular saw blade has a diameter of about 7.3 inches. The shoe can be adjusted to provide a depth of cut that is greater than or equal to about 3.0 inches.

摘要翻译： 圆锯包括壳体组件和联接到壳体组件的驱动马达组件。 输出构件由驱动马达组件驱动。 鞋可调节地安装到壳体组件。 圆锯片的直径约为7.3英寸。 可以调整鞋子以提供大于或等于约3.0英寸的切割深度。

公开(公告)号：US08793885B2

公开(公告)日：2014-08-05

申请号：US13034296

申请日：2011-02-24

申请人： Masaki Sugiyama ,  Tetsuya Hasegawa ,  Masaki Kondo ,  Tomonobu Nashimoto ,  Masayoshi Okumi ,  Takashi Miyazaki

发明人： Masaki Sugiyama ,  Tetsuya Hasegawa ,  Masaki Kondo ,  Tomonobu Nashimoto ,  Masayoshi Okumi ,  Takashi Miyazaki

IPC分类号： F01P1/02

CPC分类号： B23D45/16

摘要： A handheld engine-driven cutter is provided with a disk blade and a four-stroke engine that drives the disk blade. By employing the four-stroke engine, exhaustion of unburned gas and fuel consumption can be reduced. The engine cutter is further provided with a filter through which air provided to the four-stroke engine passes, a carburetor that mixes fuel and the air that passed through the filter, and a casing that houses the filter and the carburetor. The filter and the carburetor are arranged to align on a straight line along a direction of flow of the air passing through the filter and the carburetor.

摘要翻译： 手持式发动机驱动的切割器设置有驱动盘片的盘片和四冲程发动机。 通过采用四冲程发动机，可以减少未燃烧气体的耗尽和燃料消耗。 发动机切割器还设置有过滤器，通过该过滤器提供给四冲程发动机的空气通过，混合燃料的化油器和通过过滤器的空气，以及容纳过滤器和化油器的壳体。 过滤器和化油器布置成沿着通过过滤器和化油器的空气的流动方向在直线上对准。

公开(公告)号：US08683706B2

公开(公告)日：2014-04-01

申请号：US13033956

申请日：2011-02-24

申请人： Masayoshi Okumi ,  Masaki Kondo ,  Tomonobu Nashimoto ,  Katsumi Tozawa

发明人： Masayoshi Okumi ,  Masaki Kondo ,  Tomonobu Nashimoto ,  Katsumi Tozawa

IPC分类号： B23D45/16 ,  B23Q11/06

CPC分类号： B28D1/04 ,  B23D45/16 ,  B23D47/00 ,  B25F5/02 ,  Y10T83/9408

摘要： A handheld engine-driven cutter is provided with a disk blade and an engine that drives the disk blade, a filter through which air provided to the four-stroke engine passes, a carburetor that mixes fuel and the air that passed through the filter, a casing that houses the filter and the carburetor, at least one operation member that is operated by a user and connected to the carburetor via a link, and a shaft that is connected to the casing and supports the operation member in a swingable manner. A shaft receiving groove that supports the shaft is formed in the casing.

摘要翻译： 手持式发动机驱动的切割器设置有驱动盘片的盘片和发动机，提供给四冲程发动机的空气通过该过滤器，混合燃料的化油器和通过过滤器的空气， 壳体，其容纳过滤器和化油器，至少一个由使用者操作并经由连杆与化油器连接的操作构件，以及连接到壳体并以可摆动的方式支撑操作构件的轴。 在壳体中形成有支撑轴的轴承槽。

公开(公告)号：US08302519B2

公开(公告)日：2012-11-06

申请号：US12353354

申请日：2009-01-14

申请人： Robert E. McCracken ,  Ryan T. Harrison

发明人： Robert E. McCracken ,  Ryan T. Harrison

IPC分类号： B23D33/02

CPC分类号： B23D45/16 ,  B23D45/042 ,  B23D47/08 ,  Y10T83/7697 ,  Y10T83/7705 ,  Y10T83/8773

摘要： A power tool includes an electric motor, a motor housing in which the electric motor is at least partially positioned, a blade drivably coupled to the motor for rotation about a first axis, and a blade housing in which the blade is at least partially positioned. The blade and the blade housing are pivotably coupled to the motor housing about a second axis substantially parallel to the first axis.

摘要翻译： 电动工具包括电动机，电动机至少部分定位在其中的电动机壳体，可驱动地联接到电动机上以绕第一轴线旋转的叶片以及叶片至少部分地定位在其中的叶片壳体。 叶片和叶片壳体围绕基本上平行于第一轴线的第二轴线可枢转地联接到马达壳体。

公开(公告)号：US20120270480A1

公开(公告)日：2012-10-25

申请号：US13500142

申请日：2010-10-06

申请人： Alexander Rohde ,  Michael Keller

发明人： Alexander Rohde ,  Michael Keller

IPC分类号： B24B55/05

CPC分类号： B24B55/052 ,  B23D45/16 ,  B24B23/02 ,  B25F5/02

摘要： An electric handheld tool having a safety guard which is rotatably adjustably mounted thereto, and which further has a resilient latching means; a counter latching means borne by the electric handheld tool, and which cooperates with the latching means; and a stop means moveable between first and second portions and which cooperates with the latching means such that latching means, and counter latching means are either, on the one hand, held in engagement, or are released from engagement so as to permit selective movement of the safety guard.

摘要翻译： 一种电动手持工具，具有可旋转地可调节地安装在其上的安全保护装置，并且还具有弹性锁定装置; 一个由电动手持工具承载并与闩锁装置配合的计数器锁定装置; 以及可在第一和第二部分之间移动并且与闩锁装置配合的止动装置，使得锁定装置和反向锁定装置一方面保持接合或者从接合中释放，以允许选择性地移动 安全警卫。

公开(公告)号：US20120023760A1

公开(公告)日：2012-02-02

申请号：US13193324

申请日：2011-07-28

申请人： Guenter HAAS

发明人： Guenter HAAS

IPC分类号： B23D45/16 ,  B27B9/00

CPC分类号： B23D59/006 ,  B23D45/16 ,  B23Q11/0042 ,  B27B9/00 ,  B27G3/00 ,  B27G19/04 ,  Y10T83/7734

摘要： A circular saw, in particular hand circular saw, is disclosed. The circular saw has a workpiece support surface, a saw blade and a protective cover, which covers the saw blade in a region above a workpiece to be processed. The protective cover has such a geometry and position with respect to the saw blade that a straight line, which originates from the first deflection of a tangent applied at the intersection of the saw blade circumference with the workpiece support surface from the protective cover encloses an angle of up to 30°, in particular up to 20°, with a line perpendicular to the workpiece support surface.

摘要翻译： 公开了一种圆锯，特别是手圆锯。 圆锯具有工件支撑表面，锯片和保护盖，其在待加工的工件上方的区域中覆盖锯片。 保护盖相对于锯片具有这样的几何形状和位置，其中源自在锯片周边与工件支撑表面与保护盖相交处的切线的第一偏转的直线包围一角度 高达30°，特别是高达20°，垂直于工件支撑表面。

公开(公告)号：US08069572B2

公开(公告)日：2011-12-06

申请号：US12161196

申请日：2007-10-05

申请人： Ernst Dreher

发明人： Ernst Dreher

IPC分类号： B26B15/00 ,  B26B25/00

CPC分类号： B26B29/02 ,  B23D45/16 ,  B25B21/00 ,  B25B23/18 ,  B25F5/02 ,  B26B25/00 ,  B26B29/00 ,  H01M2/105 ,  Y10T83/828

摘要： The invention relates to a hand machine-tool, especially electrical shears, comprising a housing (13) provided with a tool head (14) and a grip part (15), an electric motor (18) arranged in the housing (13), a switch (22) for the electric motor (18), and a drive shaft (16) mounted in the tool head (14), transversally to the housing axis. The drive shaft can be driven by the electric motor (18) by means of a transmission (19). The hand machine-tool also comprises a rotary tool (11) that can be fixed to the drive shaft (16). The aim of the invention is to create a compact, structurally small and lightweight hand machine-tool for work without generating fatigue. To this end, a small-volume, rechargeable energy accumulator, preferably a lithium ion accumulator (20), which feeds the electric motor (18) and has a high charging capacity, is arranged in the grip part, together with an electronic plate (21) and the switch. The transmission (19) and at least part of the electric motor (18) are arranged in the tool head (14).

摘要翻译： 本发明涉及一种手动工具，特别是电动剪刀，其包括设置有工具头（14）和把手部分（15）的壳体（13），布置在壳体（13）中的电动机（18） 用于电动机（18）的开关（22）和安装在工具头（14）中的横向于壳体轴线的驱动轴（16）。 驱动轴可以由电动机（18）借助变速器（19）驱动。 手动工具还包括能够固定到驱动轴（16）的旋转工具（11）。 本发明的目的是为了在不产生疲劳的情况下创造一种结构紧凑，结构小巧轻便的手工工具。 为此，一个小容量的可再充电蓄能器，优选地是供给电动机（18）并具有高充电能力的锂离子蓄电池（20），与电子板（ 21）和开关。 变速器（19）和电动机（18）的至少一部分布置在工具头（14）中。