公开(公告)号：US09550028B2

公开(公告)日：2017-01-24

申请号：US14271084

申请日：2014-05-06

Applicant: Biomet Biologics, LLC

Inventor： William King ,  Jennifer E. Woodell-May

IPC: A61M5/315 ,  A61M5/31 ,  A61B10/02

CPC classification number: A61M5/31596 ,  A61B10/025 ,  A61B10/0283 ,  A61B2010/0258 ,  A61M5/3145 ,  A61M5/31511 ,  A61M2202/0413 ,  A61M2202/0443 ,  A61M2202/062 ,  A61M2202/09 ,  A61M2202/10

Abstract: A device for processing a biological material is disclosed. The device includes a syringe barrel comprising beads, a filter positioned at a close end of the barrel, a plunger insertable into the barrel through an open end, and a needle. The plunger includes a paddle assembly that is configured to mix a biological material with the beads after the biological material has been harvested from a patient.

Abstract translation: 公开了一种用于处理生物材料的装置。 该装置包括注射器筒，其包括珠，位于筒的近端的过滤器，通过开口端插入到筒中的柱塞和针。 柱塞包括桨组件，其被配置成在从患者收获生物材料之后将生物材料与珠混合。

公开(公告)号：US20160114095A1

公开(公告)日：2016-04-28

申请号：US14524115

申请日：2014-10-27

Applicant: Fenwal, Inc.

Inventor： Katherine N. Radwanski

IPC: A61M1/36 ,  A61K35/15 ,  C12N5/0786

CPC classification number: A61M1/3693 ,  A61K35/15 ,  A61M1/361 ,  A61M1/3616 ,  A61M1/3681 ,  A61M1/3683 ,  A61M1/3692 ,  A61M1/3696 ,  A61M2202/0071 ,  A61M2202/0092 ,  A61M2202/0407 ,  A61M2202/0415 ,  A61M2202/0439 ,  A61M2202/0443 ,  A61M2202/0474 ,  C12N5/0645

Abstract: A method for obtaining MNCs is set forth. The method includes: separating mononuclear cells from a biological fluid that includes red blood cells, plasma and platelets and collecting a targeted number of mononuclear cells in a suspension including plasma and residual red blood cells and platelets; concentrating the separated mononuclear cells; removing plasma from the concentrated mononuclear cells until the amount of residual plasma remaining with the concentrated mononuclear cells reaches a pre-determined volume; and adding a crystalloid solution to the concentrated mononuclear cells. Related apparatus and resultant MNC products are also disclosed.

Abstract translation: 阐述了获得MNC的方法。 该方法包括：从包括红细胞，血浆和血小板的生物流体中分离单核细胞，并在包括血浆和残留红细胞和血小板的悬浮液中收集目标数量的单核细胞; 浓缩分离的单核细胞; 从浓缩的单核细胞中除去血浆，直到浓缩的单核细胞残留的血浆量达到预定体积; 并向浓缩的单核细胞中加入晶体溶液。 还公开了相关设备和合成的MNC产品。

公开(公告)号：US20150359959A1

公开(公告)日：2015-12-17

申请号：US14758328

申请日：2013-02-06

Applicant: FENWAL, INC.

Inventor： Katherine Radwanski ,  Min Kyungyoon

IPC: A61M1/36

CPC classification number: A61M1/3681 ,  A61M1/3683 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0407 ,  A61M2202/0443 ,  A61M2205/053 ,  A61M2205/33

Abstract: A method provided for determining a range for the amount of light-energy attenuating material that may be present in a suspension containing target cells (such as MNCs), light-energy attenuating matter (such as RBCs and plasma), and a light-energy activatable compound (such as psoralen) so that a desired therapeutic effect (such as the percentage of MNCs in which apoptosis occurs) is obtained when the suspension is subjected to a known amount of light energy. In a related aspect, a method is provided for preparing a suspension containing target cells, light-energy attenuating matter, and a light-energy activatable compound so that a desired therapeutic effect is obtained when the suspension is subjected to a known amount of light energy

Abstract translation: 提供用于确定可能存在于含有靶细胞（如MNC）的悬浮液，光能衰减物质（例如RBC和等离子体））中的光能衰减材料的量的范围和光能的方法 使得当悬浮液经受已知量的光能时，获得所需的治疗效果（例如发生细胞凋亡的MNC的百分比）。 在相关方面，提供了制备含有靶细胞，光能衰减物质和光能可激发化合物的悬浮液的方法，使得当悬浮液经受已知量的光能时获得期望的治疗效果