公开(公告)号：US20160031909A1

公开(公告)日：2016-02-04

申请号：US14774261

申请日：2014-03-06

Applicant: HOFFMAN/BARRETT, LLC

Inventor： Evan R. Trivedi ,  Emily A. Waters ,  Anthony G.M. Barrett ,  Brian M. Hoffman ,  Thomas J. Meade

IPC: C07F5/00 ,  A61K49/00 ,  A61N5/10 ,  A61K45/06 ,  A61N5/06 ,  A61K49/10 ,  A61K41/00

CPC classification number: C07F5/003 ,  A61K41/0071 ,  A61K45/06 ,  A61K47/547 ,  A61K49/0036 ,  A61K49/108 ,  A61N5/062 ,  A61N5/10 ,  C07D491/22 ,  C09B47/00

Abstract: Porphyrazines capable of localizing in a tumor of a mammal are disclosed. The porphyrazines are used in methods of imaging a tumor and in methods of treating tumors, either alone or in combination with a chemotherapeutic agent and/or radiation.

Abstract translation: 公开了能够定位在哺乳动物肿瘤中的紫菜碱。 四氮杂卟啉用于成像肿瘤的方法和单独或与化学治疗剂和/或辐射组合治疗肿瘤的方法中。

公开(公告)号：US20150374828A1

公开(公告)日：2015-12-31

申请号：US14748923

申请日：2015-06-24

Applicant: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY

Inventor： Kuen Yong LEE ,  Jang Wook LEE

IPC: A61K47/24 ,  A61K49/00 ,  G01N33/574 ,  A61K47/26

CPC classification number: G01N33/574 ,  A61K49/0036 ,  A61K49/0054

Abstract: Disclosed are glucose-sensitive nanoparticles which includes a phenylboronic acid derivative and a biocompatible polymer, and is prepared as an amphiphilic conjugate having chemical binding between the phenylboronic acid derivative and the biocompatible polymer. The use of the composition can effectively collect glucose in the cancer tissue, thereby simultaneously performing diagnosis and therapy of cancer.

Abstract translation: 公开了包含苯基硼酸衍生物和生物相容性聚合物的葡萄糖敏感性纳米颗粒，并且被制备为在苯基硼酸衍生物和生物相容性聚合物之间具有化学结合的两亲性缀合物。 组合物的使用可以有效地收集癌组织中的葡萄糖，从而同时进行癌症的诊断和治疗。

公开(公告)号：US09155791B2

公开(公告)日：2015-10-13

申请号：US14088983

申请日：2013-11-25

Applicant: Health Research, Inc.

Inventor： Ravindra K. Pandey ,  Heinz Baumann ,  Yihui Chen ,  Penny Joshi ,  Nayan Patel

IPC: A61K41/00 ,  A61K49/00 ,  C07D487/22 ,  C09B23/01 ,  C09B47/00

CPC classification number: A61K41/0076 ,  A61K41/0071 ,  A61K49/0036 ,  A61K49/0052 ,  C07D487/22 ,  C09B23/0033 ,  C09B23/0066 ,  C09B47/00

Abstract: A compound in the form of a metallized tetrapyrollic photosensitizer linked to a fluorescent dye where the photosensitizer (PS), is linked by a structure that does not have detrimental radiation emittance or absorbing characteristics, to a fluorophore, usually a cyanine dye (CD). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins. The fluorophore is usually a cyanine dye with variable substituents. And, A method for determining effectiveness of PDT by comparing proportion of STAT-3 monomer with crosslinked STAT-3 dimer after PDT where the relative proportion of STAT-3 monomer to crosslinked STAT-3 directly correlates to efficacy of the PDT.

Abstract translation: 与荧光染料连接的金属四光柄光敏剂形式的化合物，其中光敏剂（PS）通过不具有有害辐射发射或吸收特性的结构连接到荧光团，通常为花青染料（CD）。 根据本发明的光敏剂是卟啉，二氢卟酚，紫嘌呤酰胺，细菌栀子酰胺，酞菁，膨胀卟啉，苯并卟啉衍生物和紫杉醇的金属化类似物。 荧光团通常是具有可变取代基的花青染料。 另外，通过比较PDT后STAT-3单体与交联的STAT-3二聚体的比例，其中STAT-3单体与交联的STAT-3的相对比例与PDT的功效直接相关，从而确定PDT有效性的方法。

公开(公告)号：US09095613B2

公开(公告)日：2015-08-04

申请号：US12673122

申请日：2009-10-28

Applicant: Yong-Doo Choi ,  Bo-Seung Jang ,  Jin-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

Inventor： Yong-Doo Choi ,  Bo-Seung Jang ,  Jin-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

IPC: A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  A61K41/00 ,  A61K33/24 ,  A61K49/00

CPC classification number: A61K41/0071 ,  A61K33/24 ,  A61K49/0036 ,  A61K49/0065 ,  Y10T428/2991

Abstract: Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.

Abstract translation: 提供了一种光敏剂 - 金属纳米颗粒电荷复合物和用于光动力学治疗或诊断的组合物。 络合物包括金属纳米颗粒，带有第一电荷的光敏剂和与金属纳米颗粒结合的连接体，并且与第一电荷具有相反极性的第二电荷充电。 在血液循环过程中，光敏剂 - 金属纳米粒子电荷复合物保持复合型，从而可以降低光敏感副作用的持续时间。 在肿瘤组织中，复合物被特异地累积，但在正常组织中，复合物难以渗透。 因此，复合物可以选择性地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用复合物进一步提高诊断肿瘤的准确性。

公开(公告)号：US20150132230A1

公开(公告)日：2015-05-14

申请号：US14605083

申请日：2015-01-26

Applicant: Kansas State University Research Foundation

Inventor： Stefan H. Bossmann ,  Deryl L. Troyer ,  Matthew T. Basel

IPC: A61K49/00

CPC classification number: A61K49/0067 ,  A61K49/0036 ,  A61K49/0056 ,  A61K49/0065 ,  A61K49/0093 ,  B82Y15/00 ,  C07K5/1021 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/37 ,  G01N33/588 ,  G01N2800/7028 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/92

Abstract: The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.

公开(公告)号：US08765098B2

公开(公告)日：2014-07-01

申请号：US12750147

申请日：2010-03-30

Applicant: Eric Andrew Appel ,  James Lupton Hedrick ,  Victor Yee-Way Lee ,  Robert Dennis Miller ,  Joseph Sly

Inventor： Eric Andrew Appel ,  James Lupton Hedrick ,  Victor Yee-Way Lee ,  Robert Dennis Miller ,  Joseph Sly

IPC: A61K49/00 ,  A61K9/00

CPC classification number: A61K49/0093 ,  A61K47/32 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0073

Abstract: A composition of matter comprising an amphiphilic star polymer, the star polymer comprising a crosslinked microgel core and 6 or more independent polymer arms covalently linked to the core, the 6 or more arms each comprising a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; wherein each individual metal selected from the group consisting of beryllium, magnesium, calcium, strontium, barium, radium, aluminum, gallium, indium, thallium, germanium, tin, lead, arsenic, antimony, bismuth, tellurium, polonium, and metals of Groups 3 to 12 of the Periodic Table has a concentration in the star polymer of greater than or equal to 0 parts per million and less than or equal to 100 parts per million.

Abstract translation: 包含两亲性星形聚合物的物质组合物，所述星形聚合物包含交联的微凝胶核心和共价连接到核心上的6个或更多个独立的聚合物臂，所述6个或更多个臂各自包含亲水性聚合物链段和疏水性聚合物链段; 其中选自组中的铍，镁，钙，锶，钡，镭，铝，镓，铟，铊，锗，锡，铅，砷，锑，铋，碲，onium onium和金属中的每种单独的金属 星形聚合物中的3至12的浓度大于或等于0ppm，小于或等于100ppm。

公开(公告)号：US20140154186A1

公开(公告)日：2014-06-05

申请号：US14117212

申请日：2012-05-30

Applicant: Jonathan S. Lindsey ,  Michael Krayer

Inventor： Jonathan S. Lindsey ,  Michael Krayer

IPC: C09B47/00 ,  A61K41/00 ,  G01N33/58 ,  A61K49/00

CPC classification number: C07D487/22 ,  A61K41/0071 ,  A61K49/0036 ,  A61N5/062 ,  C09B47/00 ,  G01N15/1404 ,  G01N33/582

Abstract: Compound of Formula I: are described, along with compositions containing the same and methods of use thereof.

Abstract translation: 描述了式I化合物，以及含有其的组合物及其使用方法。

公开(公告)号：US20130345417A1

公开(公告)日：2013-12-26

申请号：US13890126

申请日：2013-05-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Alexander Brandis ,  Ohad Mazor ,  Yoram Salomon ,  Hugo Scheer

IPC: C07F15/04

CPC classification number: A61N5/062 ,  A61F9/0008 ,  A61K31/40 ,  A61K41/0071 ,  A61K41/0076 ,  A61K49/0036 ,  A61N5/0624 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  C07F13/005 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/045

Abstract: The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO , COS , SO3 , PO3 , COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17 , 13 , and 3 of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.

公开(公告)号：US08580921B2

公开(公告)日：2013-11-12

申请号：US13548947

申请日：2012-07-13

Applicant: Carston R. Wagner

Inventor： Carston R. Wagner

IPC: C07K16/00

CPC classification number: C07K16/468 ,  A61K38/00 ,  A61K47/551 ,  A61K47/60 ,  A61K47/62 ,  A61K49/0036 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/00

Abstract: The invention provides protein nanorings.

Abstract translation: 本发明提供了蛋白质纳米结构。

公开(公告)号：US20130243694A1

公开(公告)日：2013-09-19

申请号：US13772958

申请日：2013-02-21

Applicant: CANON KABUSHIKI KAISHA

Inventor： Shinzaburo Ito ,  Kengo Kanazaki ,  Tatsuki Fukui ,  Fumiko Tomatsu ,  Masato Minami ,  Tetsuya Yano ,  Hiroyuki Aoki

IPC: A61K49/22

CPC classification number: A61K49/222 ,  A61K9/1647 ,  A61K49/0036 ,  A61K49/0093

Abstract: A particle includes a copolymer of lactic acid and glycolic acid, and at least one compound selected from silicon naphthalocyanine and derivatives of silicon naphthalocyanine, in which the particle has a particle size of 10 nm or more and less than 1000 nm.

Abstract translation: 颗粒包括乳酸和乙醇酸的共聚物，以及至少一种选自硅萘酞菁和硅萘酞菁衍生物的化合物，其中颗粒的粒径为10nm以上且小于1000nm。