公开(公告)号：US20170209029A1

公开(公告)日：2017-07-27

申请号：US15481279

申请日：2017-04-06

申请人： West View Research, LLC

发明人： Robert F. Gazdzinski

IPC分类号： A61B1/04 ,  A61B5/00 ,  A61B8/12 ,  A61B8/00 ,  A61B1/00 ,  A61B1/06

CPC分类号： A61B1/041 ,  A61B1/00009 ,  A61B1/00016 ,  A61B1/0002 ,  A61B1/00032 ,  A61B1/00036 ,  A61B1/00041 ,  A61B1/0005 ,  A61B1/00059 ,  A61B1/00156 ,  A61B1/00158 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/273 ,  A61B1/31 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/073 ,  A61B5/411 ,  A61B5/4255 ,  A61B5/7232 ,  A61B5/7282 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B8/4488 ,  A61B8/56 ,  A61B10/02 ,  A61B18/20 ,  A61B2562/162 ,  A61N2/002 ,  A61N5/1014 ,  A61N2005/1005 ,  G06F19/00 ,  G06T7/20 ,  H04L1/004

摘要： Computerized information acquisition and processing apparatus. In one embodiment, the apparatus includes an ingestible (e.g., swallowable) computerized device that includes a video apparatus, digital processor apparatus, and a wireless interface. A non-ingestible portion of the system communicates with the ingestible device via the wireless interface and, using computer software and algorithms, processes video data generated by the ingestible device relating to the intestinal tract of a living subject, so as to enhance the speed and/or accuracy of review by a physician or other individual. In one variant, the algorithmic processing by the non-ingestible apparatus includes one or more of: (i) color intensity analysis; (ii) artifact shape analysis; and/or (iii) inter-frame similarity analysis. In another variant, the ingestible device is configured to compress the data using the processor apparatus prior to transmission over the interface to conserve wireless bandwidth.

公开(公告)号：US20170087299A1

公开(公告)日：2017-03-30

申请号：US14866668

申请日：2015-09-25

申请人： Glen J. Anderson

发明人： Glen J. Anderson

IPC分类号： A61M5/172 ,  A61B5/00 ,  A61B5/145

CPC分类号： A61M5/1723 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4839 ,  A61B5/4848 ,  A61B2560/0219 ,  A61B2562/162 ,  A61M5/14276 ,  A61M2005/1726 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/3561 ,  A61M2205/50

摘要： Systems, apparatuses, kits, and methods may provide a substance. A carrier apparatus may include a reservoir to hold a payload, a sensor to detect a target in a subject and generate data corresponding to the target, a processor to allow the payload to be accessible from the reservoir based on the data, and/or a biocompatible carrier composition to hold the reservoir, the sensor, and/or the processor. The reservoir may include a placebo reservoir, a medication reservoir, a diagnostic reservoir, and/or a modification reservoir. The payload may be made available based on a diagnosis, a detection of a target in a body, a level of the target in the body, and/or a context in which the carrier apparatus is deployed. The carrier apparatus may also include a wireless rechargeable battery to power a component of the carrier apparatus. The carrier apparatus may provide diagnostic and/or therapeutic functionality.

公开(公告)号：US20170072074A1

公开(公告)日：2017-03-16

申请号：US15360523

申请日：2016-11-23

申请人： GLUSENSE LTD.

发明人： Micha GLADNIKOFF ,  Boaz BRILL ,  Itamar WEISMAN

IPC分类号： A61K49/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/00

CPC分类号： A61K49/0097 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14735 ,  A61B2562/0233 ,  A61B2562/162 ,  A61K49/0045

摘要： Apparatus is provided for implantation of live cells in a subject. The apparatus includes an implantable immunoisolation device, which includes (a) a chamber, which contains the live cells; (b) an inner membrane layer, which is disposed at an external surface of the chamber, and which comprises a selective membrane that is permeable to nutrients; and (c) an outer hydrogel layer, which comprises a hydrogel, and which is attached to and coats an outer surface of the inner membrane layer. Other embodiments are also described.

摘要翻译： 提供了用于在受试者中植入活细胞的装置。 该装置包括可植入免疫隔离装置，其包括（a）包含活细胞的腔室; （b）内膜层，其设置在所述室的外表面，并且包括可渗透营养物质的选择性膜; 和（c）外部水凝胶层，其包含水凝胶，并且附着到外层表面并涂覆其内表面。 还描述了其它实施例。

公开(公告)号：US20170007154A1

公开(公告)日：2017-01-12

申请号：US15207766

申请日：2016-07-12

申请人： Entrack, Inc.

发明人： Mir A. Imran

IPC分类号： A61B5/053 ,  A61M31/00 ,  A61N1/36 ,  A61B5/00

CPC分类号： A61M31/002 ,  A61B1/00016 ,  A61B1/00082 ,  A61B1/041 ,  A61B5/002 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/036 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/061 ,  A61B5/065 ,  A61B5/073 ,  A61B5/11 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/42 ,  A61B5/4233 ,  A61B5/4255 ,  A61B5/4839 ,  A61B5/6801 ,  A61B5/6873 ,  A61B18/14 ,  A61B2018/00482 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00821 ,  A61B2562/162 ,  A61M5/172 ,  A61M5/1723 ,  A61N1/36007 ,  A61N1/37205

摘要： A device and method for mapping, diagnosing and treating inflammatory disorders (such as Crohn's disease) or other diseases, disorders or conditions of the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed impedance and or temperature may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose, or mark the intestinal tract at a determined location along its length.

摘要翻译： 使用通过肠道的胶囊提供用于映射，诊断和治疗炎症性疾病（例如克罗恩病）或肠道的其它疾病，病症或病症的装置和方法。 此外，提供了胶囊跟踪系统，用于沿着肠道长度跟踪胶囊的位置，因为采用各种治疗和/或感测方式。 在一个变型中，使用声信号来确定胶囊的位置。 感测阻抗和/或温度的图可以从胶囊的通过导出以诊断疾病或疾病。 胶囊或随后通过的胶囊可以沿着其长度在确定的位置处理，进一步诊断或标记肠道。

公开(公告)号：US09456774B2

公开(公告)日：2016-10-04

申请号：US14581804

申请日：2014-12-23

申请人： Entrack, Inc.

发明人： Mir A. Imran ,  Olivier K. Colliou ,  Ted W. Layman ,  Sharon L. Lake ,  Harm TenHoff ,  Timothy J. Hughes

IPC分类号： A61B5/00 ,  A61B5/1459 ,  A61B1/04 ,  A61B5/06 ,  A61B5/07 ,  A61B5/03 ,  A61B5/11 ,  A61B5/145 ,  A61M5/172 ,  A61M31/00 ,  A61B1/00 ,  A61N1/36 ,  A61N1/372

CPC分类号： A61M31/002 ,  A61B1/00016 ,  A61B1/00082 ,  A61B1/041 ,  A61B5/002 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/036 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/061 ,  A61B5/065 ,  A61B5/073 ,  A61B5/11 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/42 ,  A61B5/4233 ,  A61B5/4255 ,  A61B5/4839 ,  A61B5/6801 ,  A61B5/6873 ,  A61B18/14 ,  A61B2018/00482 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00821 ,  A61B2562/162 ,  A61M5/172 ,  A61M5/1723 ,  A61N1/36007 ,  A61N1/37205

摘要： A device and method for mapping, diagnosing and treating the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed information may be derived from the pass of a capsule. Capsules may be subsequently passed through to treat the intestinal tract at a determined location along its length. One variation uses an electrical stimulation capsule to treat and/or diagnose a condition in the intestinal tract.

公开(公告)号：US09433371B2

公开(公告)日：2016-09-06

申请号：US14161582

申请日：2014-01-22

申请人： Proteus Digital Health, Inc.

发明人： Hooman Hafezi ,  Benedict Costello ,  Timothy Robertson ,  Maria Casillas Holen

IPC分类号： A61B5/00 ,  H01Q1/00 ,  H04B13/00 ,  A61B5/07 ,  A61B5/145 ,  H01Q1/22 ,  H01Q1/27 ,  H01Q9/16

CPC分类号： A61B5/073 ,  A61B5/0002 ,  A61B5/0028 ,  A61B5/028 ,  A61B5/14539 ,  A61B5/14546 ,  A61B2562/02 ,  A61B2562/162 ,  A61B2562/182 ,  H01Q1/2208 ,  H01Q1/273 ,  H01Q9/16 ,  H04B13/005 ,  Y10S128/902

摘要： Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

公开(公告)号：US09427182B2

公开(公告)日：2016-08-30

申请号：US14142017

申请日：2013-12-27

申请人： Senseonics, Incorporated

发明人： Jeremy Emken ,  Philip Huffstetler ,  Todd Whitehurst

IPC分类号： A61B5/1455 ,  A61B5/1459 ,  A61B5/145 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/0031 ,  A61B5/1459 ,  A61B2562/162

摘要： A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The membrane may reduce indicator element deterioration by preventing immune cells, such as white blood cells, from contacting the indicator element, substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the membrane, and/or permit the analyte to pass through to the indicator element. The membrane may be an opaque diffusion membrane. The sensor may include a foil. The foil may block light and/or reduce indicator element deterioration. The membrane may reduce oxidation of the indicator element.

公开(公告)号：US20160183842A1

公开(公告)日：2016-06-30

申请号：US14873288

申请日：2015-10-02

申请人： Integrated Sensing Systems, Inc.

发明人： Nader Najafi ,  Catherine Hook Morgan-Leonard

IPC分类号： A61B5/07 ,  A61B5/03 ,  A61M5/172 ,  A61B5/01 ,  A61B5/145 ,  A61B5/0205 ,  A61B5/00 ,  A61B5/021

CPC分类号： A61B5/076 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/036 ,  A61B5/6869 ,  A61B5/6882 ,  A61B2560/0219 ,  A61B2562/0247 ,  A61B2562/028 ,  A61B2562/085 ,  A61B2562/162 ,  A61M5/1723

摘要： A system and surgical procedure for monitoring physiological parameters within an internal organ of a living body. The procedure entails making a first incision to expose the organ and a second incision through an external wall of the organ and into an internal cavity. A sensing unit is placed in the second incision such that a proximal end thereof remains outside the organ. The unit includes a sensing device having a sensing element for sensing the physiological parameter within the organ, and an anchor to which the sensing device is secured. The unit occludes the second incision and a distal end of the unit does not extend more than one centimeter into the cavity. The anchor is then secured to the wall of the organ, after which the first incision is closed and a readout device telemetrically communicates with the sensing device to obtain a reading of the physiological parameter.

摘要翻译： 用于监测活体内脏器官内的生理参数的系统和外科手术。 该过程需要进行第一切口以将器官和第二切口通过器官的外壁暴露于内腔中。 感测单元被放置在第二切口中，使得其近端保持在器官外部。 该单元包括感测装置，其具有用于感测器官内的生理参数的感测元件和固定感测装置的锚。 该单元封闭第二切口，并且该单元的远端不延伸超过一厘米到腔中。 然后将锚固定到器官的壁上，之后闭合第一切口，并且读出装置与感测装置遥测地通信以获得生理参数的读数。

公开(公告)号：US20160095499A1

公开(公告)日：2016-04-07

申请号：US14504458

申请日：2014-10-02

申请人： Capso Vision, Inc.

发明人： Mikael Trollsas ,  Mark Hadley ,  Ganyu Lu ,  Kang-Huai Wang

IPC分类号： A61B1/00 ,  A61B1/06 ,  A61B5/00 ,  H04N5/225 ,  A61B1/04

CPC分类号： A61B1/00075 ,  A61B1/00016 ,  A61B1/0002 ,  A61B1/0011 ,  A61B1/041 ,  A61B1/06 ,  A61B5/073 ,  A61B2562/162 ,  H04N5/2252 ,  H04N2005/2255

摘要： The present invention discloses a capsule device with textured structural surface so that the capsule device has desired surface properties when it travels through designated regions in the gastrointestinal tract. The capsule device according to the present invention comprises a sensor and a capsule housing, where the sensor is sealed in the capsule housing. The capsule housing having a textured surface to cover at least one region of an exterior surface of the capsule housing to increase holding force between the luminal wall and the capsule device when the capsule device travels inside a gastrointestinal (GI) tract after being swallowed. A coating can be added to cover the textured surface so as to make the capsule surface smooth for easy to swallow. The coating layer will dissolve when the capsule device is in contact with the acid fluid inside the GI tract.

摘要翻译： 本发明公开了一种具有纹理结构表面的胶囊装置，使得胶囊装置当其穿过胃肠道中的指定区域时具有期望的表面特性。 根据本发明的胶囊装置包括传感器和胶囊壳体，其中传感器被密封在胶囊壳体中。 胶囊壳体具有纹理表面以覆盖胶囊壳体的外表面的至少一个区域，以在胶囊装置吞咽之后在胃肠道（GI）管道内行进时增加腔壁和胶囊装置之间的保持力。 可以添加涂层以覆盖纹理表面，以使胶囊表面光滑以容易吞咽。 当胶囊装置与胃肠道内的酸性液体接触时，涂层将溶解。

公开(公告)号：US20160051197A1

公开(公告)日：2016-02-25

申请号：US14703833

申请日：2015-05-04

申请人： Samsung Electronics Co., Ltd.

发明人： Mitsuo UMEMOTO ,  Yung-Cheol KONG ,  Woon-Bae KIM ,  Pyoung-Wan KIM ,  Kyong-Soon CHO

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/0215

CPC分类号： A61B5/6861 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/14503 ,  A61B5/14532 ,  A61B2562/162 ,  A61B2562/166

摘要： Provided is a body-implantable package for processing biosensed-data for wireless communication to an external device. The package includes a tube closed by a cover, therein, a chip with a strained layer affixed thereto to form a flexible laminar circuit. The cover is fitted over an open end of the tube after the laminated chip and strained layer are inserted therein. The chip is constructed of and rolled in one or more turns into a generally cylindrical shape. The strained layer is affixed to a surface of the chip automatically to cause the flexible laminar circuit to curl into a generally cylindrical shape to fit within the tube.

摘要翻译： 提供了一种用于处理用于到外部设备的无线通信的生物许可数据的体内植入式包装。 该封装包括一个由盖子封闭的管，其中具有固定到其上的应变层的芯片形成柔性层流电路。 在层压芯片和应变层插入其中之后，将盖安装在管的开口端上。 芯片由一个或多个匝构成并卷成大致圆柱形。 应变层自动固定在芯片的表面上，使得柔性层流电路卷曲成大致圆柱形，以装配在管内。