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11.发明申请COMPOSITIONS AND METHODS COMPRISING GLYCYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 有权包含非经济生物活性的甘氨酸 - 三氮唑合成物的组合物和方法公开(公告)号：US20140363415A1
公开(公告)日：2014-12-11
申请号：US14262247
申请日：2014-04-25
Applicant: aTyr Pharma, Inc.
Inventor： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
IPC: C12N9/00
CPC classification number: A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Abstract translation: 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物活性的多核苷酸，以及与其相关的组合物和方法。
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公开(公告)号：US20140335087A1
公开(公告)日：2014-11-13
申请号：US14368759
申请日：2012-12-27
Applicant: aTyr Pharma, Inc.
Inventor： Ying Ji Buechler , Chi-Fang Wu , Ryan Andrew Adams , Jeffrey D. Watkins , John D. Mendlein
CPC classification number: C12N9/93 , A61K38/00 , C07K16/00 , C07K2319/02 , C07K2319/21 , C07K2319/30 , C07K2319/50 , C12Y601/01002 , C12Y601/01012 , Y02A50/385 , Y02A50/389 , Y02A50/463
Abstract: The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides.
Abstract translation: 本发明提供天冬氨酰-tRNA合成酶和Fc区缀合多肽（DRS-Fc缀合物），例如DRS-Fc融合蛋白，包含其的组合物，以及使用这种缀合物和组合物治疗或诊断各种病症的方法。 本发明的DRS-Fc缀合物相对于相应的未修饰的DRS多肽具有改善的控制释放性质，稳定性，半衰期和其它药代动力学和生物学性质。
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13.发明授权Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities 有权包含具有非规范生物活性的甘氨酰-tRNA合成酶的组合物和方法公开(公告)号：US08747840B2
公开(公告)日：2014-06-10
申请号：US13753272
申请日：2013-01-29
Applicant: aTyr Pharma, Inc.
Inventor： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
IPC: A61K38/43 , C12N9/00 , C12N15/00 , C12P21/04 , C12N5/04 , C12N1/20 , A61K38/53 , C12N15/10 , C07K1/14 , C07H21/04
CPC classification number: A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Abstract translation: 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。
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公开(公告)号：US11807687B2
公开(公告)日：2023-11-07
申请号：US17062100
申请日：2020-10-02
Applicant: aTyr Pharma, Inc.
Inventor： Luke Burman , Yeeting Chong , Leslie Ann Greene , David King , Zhiwen Xu , Ryan Andrew Adams
IPC: A61K39/395 , C07K16/28 , A61P35/04 , A61P35/00 , A61K39/00
CPC classification number: C07K16/2863 , A61K39/3955 , A61P35/00 , A61P35/04 , A61K39/001103 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/52
Abstract: Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
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Patent Agency Ranking
公开(公告)号：US20180282402A1
公开(公告)日：2018-10-04
申请号：US15828170
申请日：2017-11-30
Applicant: aTyr Pharma, Inc.
Inventor： Ryan Andrew Adams , Luke Burman , Yeeting Chong , David King , John D. Mendlein , Leslie Nangle Greene , Kathleen Ogilvie , Kaitlyn Rauch
IPC: C07K16/18 , A61K45/06 , A61K39/395 , A61P35/04
Abstract: Provided are antibodies that specifically bind to human histidyl-tRNA synthetase and related therapeutic compositions and methods for treating cancer, including as standalone therapies or in combination with cancer immunotherapies, for example, immune checkpoint modulators such as PD-1 inhibitors.
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公开(公告)号：US09943577B2
公开(公告)日：2018-04-17
申请号：US15365079
申请日：2016-11-30
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
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17.发明申请公开(公告)号：US20170296635A1
公开(公告)日：2017-10-19
申请号：US15415328
申请日：2017-01-25
Applicant: aTyr Pharma, Inc.
Inventor： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
CPC classification number: A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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公开(公告)号：US20170202933A1
公开(公告)日：2017-07-20
申请号：US15365079
申请日：2016-11-30
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
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公开(公告)号：US20150140072A1
公开(公告)日：2015-05-21
申请号：US14541792
申请日：2014-11-14
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
IPC: C12N9/00
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Abstract translation: 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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