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公开(公告)号：US20230159888A1
公开(公告)日：2023-05-25
申请号：US17923246
申请日：2021-05-04
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin SAHIN , Pakize Neslihan TASLI , Oguz Kaan KIRBAS , Ezgi AVSAR ABDIK , Huseyin ABDIK , Burcu KASAPOGLU USTA
IPC: C12N5/0793
CPC classification number: C12N5/0619 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2506/1361 , C12N2500/36 , C12N2500/32 , C12N2500/38
Abstract: A medium-based method for inducing specific differentiation of dental stem cells into dopaminergic neurons is provided. The method includes seeding the dental stem cells at a concentration of 5000 cells/cm2, following 24-hour incubation, introducing the cells into first part neurogenic induction medium and continuing the medium application for 4 days; subsequently, introducing the cells into the second part neurogenic induction medium and continuing the medium application for 2 days; and terminating the differentiation at the end of 6 days. The objective of the present invention is to develop cellular applications for use in treatment of neurodegenerative diseases and medications related to the said diseases.
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公开(公告)号：US20220062348A1
公开(公告)日：2022-03-03
申请号：US17277734
申请日：2019-09-17
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin SAHIN , Pakize Neslihan TASLI , Ezgi AVSAR APDIK , Ayse Sezim SAFAK
Abstract: A cartilage is generated by a formulation, wherein the formulation is produced by an isolated septal cartilage exosome released by cells isolated from a septal cartilage to a medium. The objective of the isolated septal cartilage exosome is to generate the cartilage to be used in a treatment of cartilage tissue defects, such as osteoarthritis or arthrosis, since the cartilage induces a cartilage formation and also suppresses an inflammatory response.
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公开(公告)号：US20220000910A1
公开(公告)日：2022-01-06
申请号：US17288596
申请日：2018-11-08
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin SAHIN , Pakize Neslihan TASLI , Oguz Kaan KIRBAS , Taha Bartu HAYAL , Batuhan Turhan BOZKURT , Berna BULBUL , Seda BEYAZ
IPC: A61K33/241 , A61K9/14 , A61P35/00 , A61K47/10
Abstract: Use of nano-sized lead borate compounds for treatment purposes due to their selective anticancer activity on p53 mutant breast cancer cell line, T47D is disclosed. The method of synthesizing nano-sized lead borates of the present invention comprises the steps of preparing a borate buffer solution by sodium hydroxide and boric acid, dissolving lead nitrate (and preferably PEG) in distilled water by stirring, mixing the borate buffer solution with the lead nitrate (and preferably PEG) solution, washing the resulting solution with distilled water and drying to remove the impurities.
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公开(公告)号：US20180318206A1
公开(公告)日：2018-11-08
申请号：US15772864
申请日：2016-11-01
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin SAHIN , Ozge Sezin SOMUNCU , Pakize Neslihan TASLI , Okan DEMIR
CPC classification number: A61K8/985 , A61K9/0014 , A61K9/0021 , A61K9/06 , A61K35/36 , A61K47/44 , A61Q7/00
Abstract: The present invention relates to a product which prevents hair loss and enables growth of healthy new hair by stem cell application. With the present invention, the newly growing hair is ensured to have the same color with the person's own hair color and thus prevents increase of grey hair. The product of the present invention is comprised of a carrier and active ingredient.
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