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公开(公告)号：US20170226135A1
公开(公告)日：2017-08-10
申请号：US15435097
申请日：2017-02-16
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Randy W. JACKSON , Jodie HAMRICK , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/198 , A61K31/69 , A61K45/06 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20160016978A1
公开(公告)日：2016-01-21
申请号：US14759853
申请日：2014-01-10
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT , Randy W. JACKSON
IPC分类号： C07F5/02 , A61K31/496 , A61K31/407 , A61K31/69 , A61K31/546
CPC分类号： C07F5/025 , A61K31/407 , A61K31/496 , A61K31/546 , A61K31/69 , A61K45/06 , Y02A50/47 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20150291630A1
公开(公告)日：2015-10-15
申请号：US14649527
申请日：2013-12-05
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20200157123A1
公开(公告)日：2020-05-21
申请号：US16616294
申请日：2018-05-25
发明人： Christopher J. BURNS , Denis DAIGLE , Guo-Hua CHU , Jodie HAMRICK , Matthew LUCAS , Steven A. Boyd , Allison L. ZULLI , Eugen F. MESAROS , Stephen M. CONDON , Robert E. Lee TROUT , Cullen L. MYERS
摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20180194783A1
公开(公告)日：2018-07-12
申请号：US15787224
申请日：2017-10-18
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04 , Y02A50/473
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20160326189A1
公开(公告)日：2016-11-10
申请号：US15212959
申请日：2016-07-18
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20160024121A1
公开(公告)日：2016-01-28
申请号：US14773717
申请日：2014-03-13
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/69 , A61K45/06 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/483
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20150361107A1
公开(公告)日：2015-12-17
申请号：US14736921
申请日：2015-06-11
发明人： Robert E. Lee TROUT
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
摘要翻译： 本文描述了调节β-内酰胺酶活性的化合物和组合物。 在一些实施方案中，本文所述的化合物抑制β-内酰胺酶。 在某些实施方案中，本文所述的化合物可用于治疗细菌感染。
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公开(公告)号：US20150224125A1
公开(公告)日：2015-08-13
申请号：US14693318
申请日：2015-04-22
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT , Randy W. JACKSON
CPC分类号： C07F5/025 , A61K31/407 , A61K31/496 , A61K31/546 , A61K31/69 , A61K45/06 , Y02A50/47 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
摘要翻译： 本文描述了调节β-内酰胺酶活性的化合物和组合物。 在一些实施方案中，本文所述的化合物抑制β-内酰胺酶。 在某些实施方案中，本文所述的化合物可用于治疗细菌感染。
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公开(公告)号：US20140171390A1
公开(公告)日：2014-06-19
申请号：US14099633
申请日：2013-12-06
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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