公开(公告)号：US20160025116A1

公开(公告)日：2016-01-28

申请号：US14861930

申请日：2015-09-22

Applicant: Universiteit Leiden

Inventor： Paul Vulto ,  Gerald Urban ,  Susann Podszun

IPC: F15D1/00

CPC classification number: B01L3/502707 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0605 ,  B01L2400/0688 ,  B01L2400/082 ,  B01L2400/086 ,  B01L2400/088 ,  Y10T137/8593

Abstract: The present invention relates to phaseguide patterns for use in fluid systems such as channels, chambers, and flow through cells. In order to effectively control filling and/or emptying of fluidic chambers and channels, techniques for a controlled overflowing of phaseguides are proposed. In addition, techniques of confined liquid patterning in a larger fluidic structure, including approaches for patterning overflow structures and the specific shape of phaseguides, are provided. The invention also proposes techniques to effectively rotate the advancement of a liquid/air meniscus over a certain angle. In particular, a phaseguide pattern for guiding a flow of a liquid contained within a compartment is provided, wherein an overflow of the phaseguide by a moving liquid phase is controlled by a local change in capillary force along the phaseguide, wherein said overflow by the liquid over the phaseguide is provoked at the position of the local change in capillary force.

Abstract translation: 本发明涉及用于流体系统（例如通道，室和流通池）中的相位导图。 为了有效地控制流体室和通道的填充和/或排空，提出了用于受控溢流的相位导引的技术。 此外，还提供了在更大的流体结构中的限制液体图案化技术，包括图案化溢出结构的方法和相位导体的具体形状。 本发明还提出了在一定角度上有效地旋转液体/空气弯液面的推进的技术。 特别地，提供了用于引导容纳在隔间内的液体的流动的相位指示图案，其中通过移动液相的相位导向器的溢流通过沿着相位导管的毛细管力的局部变化来控制，其中所述液体溢出 在该位置上引发了相位导致毛细血管力变化的位置。

公开(公告)号：US20150238952A1

公开(公告)日：2015-08-27

申请号：US14426920

申请日：2013-09-10

Applicant: UNIVERSITEIT LEIDEN

Inventor： Paul Vulto ,  Sebastiaan Johannes Trietsch ,  Ender Yildirim

IPC: B01L3/00

CPC classification number: B01L3/00 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0642 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/161 ,  B01L2400/0688 ,  B01L2400/086 ,  B01L2400/088

Abstract: The present invention relates to an apparatus for controlling the shape and/or position of a moveable fluid-fluid meniscus, the apparatus comprising a volume for containing and directing fluid, the filling direction being a downstream direction, including the meniscus and the volume having at least a first structure defining a capillary pressure barrier along which the meniscus tends to align, the capillary pressure barrier and the meniscus defining a boundary in the volume between at least two sub-volumes,wherein (a) the capillary pressure barrier is stabilized by subtending at both ends an angle with a wall of the volume that on the downstream side of the capillary pressure barrier is greater than 90°, while not providing a deliberate fluid alignment weakness along the capillary pressure barrier that reduces the stability of the capillary pressure barrier and/or (b) wherein the capillary pressure is stabilized by providing a stretching barrier at a distance less than the maximum stretching distance of the fluid-fluid meniscus upon alignment along the capillary pressure barrier in the absence of the stretching barrier, (c) the capillary pressure barrier is stabilized by subtending at one end an angle with a wall of the volume that on the downstream side of the capillary pressure barrier is greater than 90°, and at the other end is stabilized by providing a stretching barrier at a distance less than the maximum stretching distance of the fluid-fluid meniscus upon alignment along the capillary pressure barrier in the absence of the stretching barrier; wherein the stretching barrier is shaped such that at least one directional component is orthogonal to the capillary pressure barrier.

Abstract translation: 本发明涉及一种用于控制可移动流体 - 液体弯液面的形状和/或位置的装置，该装置包括用于容纳和引导流体的容积，填充方向是下游方向，包括弯月面和体积具有 至少一个限定毛细管压力屏障的第一结构，所述弯月面倾向于沿其对准，所述毛细管压力屏障和所述弯液面在至少两个子体积之间限定所述体积中的边界，其中（a）毛细管压力屏障通过对 在两端处，与毛细管压力屏障的下游侧的体积壁成一角度大于90°，​​而不会沿着毛细管压力屏障提供有意的流体排列弱点，这降低了毛细管压力屏障的稳定性， /或（b）其中通过在小于最大str的距离处提供拉伸屏障来稳定毛细管压力 在不存在拉伸屏障的情况下沿着毛细管压力屏障对准流体 - 液体弯液面的蚀刻距离，（c）通过在一端与一个下游侧的体积的壁成一角度来稳定毛细管压力屏障 的毛细管压力屏障大于90°，​​并且在另一端通过在不存在毛细管压力屏障的情况下沿着毛细管压力屏障对准时在比液体液体弯液面的最大拉伸距离小的距离处提供拉伸屏障来稳定 拉伸屏障; 其中所述拉伸屏障被成形为使得至少一个方向分量正交于所述毛细管压力屏障。