公开(公告)号：US20160151579A1

公开(公告)日：2016-06-02

申请号：US14905078

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Matt Schumann ,  Mark Pawulski

IPC分类号： A61M5/315

CPC分类号： A61M5/31551 ,  A61M5/20 ,  A61M5/31535 ,  A61M5/31536 ,  A61M5/31553 ,  A61M5/31578 ,  A61M5/31583 ,  A61M2005/3126

摘要： A drive mechanism (11) for a delivery device comprising a drive member (17) for driving a piston rod (13); a moveable dose setting member (19, 35) being disengaged from the drive member (17) in a dose setting state and being moveable in a drive direction in a dose delivery state, wherein the dose setting member (19, 35) engages with the drive member (17) in the dose delivery state in such a manner that the movement of the dose setting member (19, 35) in the drive direction is transferred to the drive member (17); and a spring member (21) being coupled to the dose setting member (19, 35) in such a manner that the movement of the dose setting member (19, 35) in a setting direction loads the spring member (21) in the dose setting state, the spring force of the loaded spring member (21) driving the dose setting member (19, 35) in the drive direction in the dose delivery state.

摘要翻译： 一种用于输送装置的驱动机构（11），包括用于驱动活塞杆（13）的驱动构件（17）。 可动剂量设定部件（19,35）以剂量设定状态与驱动部件（17）脱离啮合并且能够在剂量输送状态下沿驱动方向移动，其中剂量设定部件（19,35）与 驱动构件（17）以剂量设定构件（19,35）在驱动方向上的移动传递到驱动构件（17）的方式处于剂量递送状态; 以及弹簧构件（21），其以这样的方式联接到剂量设定构件（19,35），使得剂量设定构件（19,35）在设定方向上的移动以所述剂量加载所述弹簧构件（21） 在剂量输送状态下，驱动剂量设定部件（19,35）的驱动方向的负载弹簧部件（21）的弹簧力。

公开(公告)号：US20160136358A1

公开(公告)日：2016-05-19

申请号：US14905382

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315

CPC分类号： A61M5/31541 ,  A61M5/20 ,  A61M5/31528 ,  A61M5/31551 ,  A61M5/31593

摘要： The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament including a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device comprises a cartridge (80) containing liquid, preferably a medicament, a dosing element (40, 130), which rotates during dose selecting, a last dose nut (110) coupled to the dosing element (40, 130) during dose selecting such that rotation of the dosing element (40, 130) causes an axial movement of the last dose nut (110), and a stop element (137), which is provided on the dosing element (40, 130) and which blocks further movement of the last dose nut (110), if a dose is selected corresponding to the amount of liquid left in the cartridge (80). The device further comprises a last dose sleeve (120) rotationally coupled to the dosing element (40, 130) during dose selecting and rotationally de-coupled from the dosing element (40, 130) during dose dispensing.

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置，所述药物包括剂量限制器，用于防止剂量的设定超过药物递送装置的药筒中残留的液体量。 所述装置包括在剂量选择期间旋转的剂量元件（40,130），所述剂量容器包含液体，优选为药物，所述剂量元件在剂量选择期间与所述计量元件（40,130）相耦合的最后剂量螺母（110） 使得配量元件（40,130）的旋转导致最后剂量螺母（110）的轴向运动和设置在计量元件（40,130）上的止动元件（137），并且阻止进一步的运动 如果对应于留在盒（80）中的液体的量选择剂量，则最后剂量螺母（110）的位置。 该装置还包括在剂量分配期间在剂量选择期间旋转地联接到计量元件（40,130）的最后剂量套筒（120），并从定量元件（40,130）旋转地脱耦合。

公开(公告)号：US10441724B2

公开(公告)日：2019-10-15

申请号：US14904736

申请日：2014-07-17

申请人： Sanofi

发明人： Tom Oakley ,  Matt Schumann ,  Stuart Milne

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： A drive mechanism for a delivery device is presented. The drive mechanism comprises a housing (24) and a piston rod (6) having a longitudinal axis (x) and a piston rod feature (17). The drive mechanism further comprises a drive member (1) being movable with respect to the housing (24). The drive member (1) comprises a drive feature (15). The drive feature (15) is selectively engageable with the piston rod feature (17) by the radial displacement of the drive member (1) with respect to the piston rod (6). When the drive member (1) is in the first position, the drive member (1) is disengaged from the piston rod (6), and when the drive member (1) is in the second position, the drive feature (15) is engaged with the piston rod feature (17). When the drive member (1) moves distally with respect to the housing (24), said distal movement is transferred to the piston rod (6) such that the piston rod (6) moves distally with respect to the housing (24).

公开(公告)号：US20160158456A1

公开(公告)日：2016-06-09

申请号：US14904736

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Matt Schumann ,  Stuart Milne

IPC分类号： A61M5/315

CPC分类号： A61M5/31578 ,  A61M5/20 ,  A61M5/3146 ,  A61M5/31501 ,  A61M5/31535 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/31561 ,  A61M5/3157 ,  A61M5/31573 ,  A61M5/31583 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/586

摘要： A drive mechanism for a delivery device is presented. The drive mechanism comprises a housing (24) and a piston rod (6) having a longitudinal axis (x) and a piston rod feature (17). The drive mechanism further comprises a drive member (1) being movable with respect to the housing (24). The drive member (1) comprises a drive feature (15). The drive feature (15) is selectively engageable with the piston rod feature (17) by the radial displacement of the drive member (1) with respect to the piston rod (6). When the drive member (1) is in the first position, the drive member (1) is disengaged from the piston rod (6), and when the drive member (1) is in the second position, the drive feature (15) is engaged with the piston rod feature (17). When the drive member (1) moves distally with respect to the housing (24), said distal movement is transferred to the piston rod (6) such that the piston rod (6) moves distally with respect to the housing (24).

摘要翻译： 提出了一种用于输送装置的驱动机构。 驱动机构包括具有纵向轴线（x）和活塞杆特征（17）的壳体（24）和活塞杆（6）。 驱动机构还包括可相对于壳体（24）移动的驱动构件（1）。 驱动构件（1）包括驱动特征（15）。 通过驱动构件（1）相对于活塞杆（6）的径向位移，驱动特征（15）可选择性地与活塞杆特征（17）接合。 当驱动部件（1）处于第一位置时，驱动部件（1）从活塞杆（6）脱离，当驱动部件（1）处于第二位置时，驱动部件（15）为 与活塞杆特征（17）接合。 当驱动构件（1）相对于壳体（24）向远侧移动时，所述远端运动被传递到活塞杆（6），使得活塞杆（6）相对于壳体（24）向远侧移动。

公开(公告)号：US20160158451A1

公开(公告)日：2016-06-09

申请号：US14904746

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Matt Schumann ,  Stuart Milne

IPC分类号： A61M5/31 ,  A61M11/00

CPC分类号： A61M5/3146 ,  A61M5/1452 ,  A61M5/31511 ,  A61M5/31515 ,  A61M5/31583 ,  A61M11/007 ,  A61M15/009 ,  A61M2005/1402

摘要： The priming configuration comprises a piston rod (1), a bung (2), which is provided to be driven by the piston rod, and a movable element (5), which is engaged with the piston rod. The movable element is arranged to be movable in a predefined direction (10) with respect to the piston rod by a user of the drug delivery device. A movement of the movable element in the predefined direction advances the piston rod in a further direction (11), providing a priming of the drug delivery device before use. The predefined direction may especially be transverse to the further direction, and the further direction may especially be directed from the piston rod towards the bung (2). A gap (12) or clearance between the piston rod (1) and the bung (2) can thus be removed, and the stiction of the bung (2) to the cartridge (3) can be reduced.

摘要翻译： 起动构造包括活塞杆（1），设置成由活塞杆驱动的栓（2）和与活塞杆接合的可动元件（5）。 可移动元件布置成可以由药物输送装置的使用者相对于活塞杆在预定方向（10）上移动。 可移动元件在预定方向上的运动使得活塞杆在另一方向（11）上前进，在使用前提供了药物输送装置的起动。 预定的方向可以特别地横向于另外的方向，并且进一步的方向可以特别地从活塞杆朝向栓（2）。 因此，可以移除活塞杆（1）和塞子（2）之间的间隙（12）或间隙，并且可以减小塞子（2）到墨盒（3）的粘性。

公开(公告)号：US20160151580A1

公开(公告)日：2016-06-02

申请号：US14905393

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315

CPC分类号： A61M5/31551 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31536 ,  A61M5/31541 ,  A61M5/31545 ,  A61M5/31553 ,  A61M5/31583 ,  A61M2005/3126 ,  A61M2005/31518 ,  A61M2005/3154

摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge holder (20) for receiving a cartridge (170), a lead screw (30) and means (40, 90) for driving the lead screw (30) during dose dispensing. The lead screw (30) is coupled to the cartridge holder (20) such that the cartridge holder (20) is axially displaced with respect to the housing (10) and the lead screw (30) during dose dispensing.

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置。 该装置包括壳体（10），用于容纳盒（170）的盒保持器（20），用于在剂量分配期间驱动丝杠（30）的导螺杆（30）和装置（40,90）。 导螺杆（30）联接到药筒保持器（20），使得药筒保持器（20）在剂量分配期间相对于壳体（10）和丝杠（30）轴向移位。

公开(公告)号：US20160151574A1

公开(公告)日：2016-06-02

申请号：US14904737

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315

摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises at least one clicker mechanism (52, 64; 143, 153) for generating a haptic and/or audible feedback during dose selecting, wherein the clicker mechanism (143, 153) generates a different feed-back when selecting single units or multiples of single units.

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置。 所述装置包括用于在剂量选择期间产生触觉和/或听觉反馈的至少一个鸣叫机构（52,64; 143,153），其中，当选择单个单元时，所述答题机构（143,153）产生不同的反馈 单位数倍数。

公开(公告)号：US20160151572A1

公开(公告)日：2016-06-02

申请号：US14905390

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315

CPC分类号： A61M5/3155 ,  A61M5/31528 ,  A61M5/31541 ,  A61M5/31548 ,  A61M5/31553 ,  A61M5/31578 ,  A61M5/31593 ,  A61M2005/2403 ,  A61M2005/3126

摘要： The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament including a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device comprises a housing (10, 20), a dose selector (140) for selecting a dose by rotation relative to the housing (10, 20), a dosing element (40, 130), and a releasable clutch (45, 143) for rotationally coupling the dosing element (40, 130) to the dose selector (140) during dose selecting and for rotationally decoupling the dosing element (40, 130) from the dose selector (140) during dose dispensing. The clutch comprises a male spline (45), a corresponding female spline (143) and a curved or inclined surface (142) which is orientated such that re-engagement of the clutch guides the male spline (45) into a predefined rotational orientation with respect to the female spline (143).

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置，所述药物包括剂量限制器，用于防止剂量的设定超过药物递送装置的药筒中残留的液体量。 所述装置包括壳体（10,20），用于通过相对于所述壳体（10,20）旋转来选择剂量的剂量选择器（140），配量元件（40,130）和可释放离合器（45,143） ），用于在剂量选择期间将给药元件（40,130）旋转耦合到剂量选择器（140），并且用于在剂量分配期间将计量元件（40,130）与剂量选择器（140,130）旋转地分离。 离合器包括阳花键（45），对应的雌花键（143）和弯曲或倾斜表面（142），其被定向成使得离合器的再接合将阳花键（45）引导成预定的旋转取向， 相对于雌花键（143）。

公开(公告)号：US20160144121A1

公开(公告)日：2016-05-26

申请号：US14905222

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Matt Schumann ,  Stuart Milne

IPC分类号： A61M5/315

CPC分类号： A61M5/3155 ,  A61M5/20 ,  A61M5/3146 ,  A61M5/31551 ,  A61M5/31553 ,  A61M5/31558 ,  A61M5/31561 ,  A61M5/31568 ,  A61M5/3157 ,  A61M5/31578 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583

摘要： A drive mechanism for a delivery device or a positioning mechanism comprising a rod (5), a rotatable cam member (9), and a follower member (6) being coupled to the cam member (9) in such a manner that a rotation of the cam member (9) is transferred to a reciprocating movement of the follower member (6) or a part thereof (7), the follower member (6) being coupled to the rod (5) via a ratchet mechanism (62, 64) in such a manner that the reciprocating movement of the follower member (6) or the part thereof (7) drives the rod (5).

摘要翻译： 一种用于输送装置或定位机构的驱动机构，包括杆（5），可旋转凸轮构件（9）和从动构件（6），其以这样的方式联接到所述凸轮构件（9） 凸轮构件（9）被转移到从动构件（6）或其一部分（7）的往复运动，从动构件（6）通过棘轮机构（62,64）联接到杆（5） 从动构件（6）或其一部分（7）的往复运动驱动杆（5）。

公开(公告)号：US10596323B2

公开(公告)日：2020-03-24

申请号：US14904737

申请日：2014-07-17

申请人： Sanofi

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315 ,  A61M5/31 ,  A61M5/24

摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises at least one clicker mechanism (52, 64; 143, 153) for generating a haptic and/or audible feedback during dose selecting, wherein the clicker mechanism (143, 153) generates a different feed-back when selecting single units or multiples of single units.