The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament including a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device comprises a housing (10, 20), a dose selector (140) for selecting a dose by rotation relative to the housing (10, 20), a dosing element (40, 130), and a releasable clutch (45, 143) for rotationally coupling the dosing element (40, 130) to the dose selector (140) during dose selecting and for rotationally decoupling the dosing element (40, 130) from the dose selector (140) during dose dispensing. The clutch comprises a male spline (45), a corresponding female spline (143) and a curved or inclined surface (142) which is orientated such that re-engagement of the clutch guides the male spline (45) into a predefined rotational orientation with respect to the female spline (143).