公开(公告)号：US10195356B2

公开(公告)日：2019-02-05

申请号：US14905382

申请日：2014-07-17

申请人： Sanofi

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315 ,  A61M5/20

摘要： A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device includes a cartridge containing liquid, a dosing element, which rotates during dose selecting, a last dose nut coupled to the dosing element during dose selecting such that rotation of the dosing element causes an axial movement of the last dose nut, and a stop element, which is provided on the dosing element and which blocks further movement of the last dose nut, if a dose is selected corresponding to the amount of liquid left in the cartridge. The device further includes a last dose sleeve rotationally coupled to the dosing element during dose selecting and rotationally decoupled from the dosing element during dose dispensing.

公开(公告)号：US10155089B2

公开(公告)日：2018-12-18

申请号：US14905393

申请日：2014-07-17

申请人： Sanofi

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315 ,  A61M5/24 ,  A61M5/20 ,  A61M5/31

摘要： A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing, a cartridge holder for receiving a cartridge, a lead screw and means for driving the lead screw during dose dispensing. The lead screw is coupled to the cartridge holder such that the cartridge holder is axially displaced with respect to the housing and the lead screw during dose dispensing.

公开(公告)号：US20160158454A1

公开(公告)日：2016-06-09

申请号：US14904739

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315 ,  A61M5/24

摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge (170) containing a medicament and a last dose protection mechanism for preventing the selection of a dose, which exceeds the amount of medicament left in a cartridge (170). This last dose protection mechanism comprises a first member (60), which is rotatable in a first direction during dose FIG. 2 selecting and in the opposite direction during dose dispensing, a second member (50) coupled to the first member (60) and to the housing (10) such that the second member is moved relative to the first member (60) and to the housing (10) upon rotation of the first member (60) and a third member (100) which is moved relative to the first and second member (50, 60) during dose dispensing. Abutment of the second and third member (50, 100) prevents increasing the selected dose.

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置。 该装置包括壳体（10），容纳药物的药筒（170）和用于防止剂量的最后剂量保护机构，其超过药盒（170）中留下的药物量。 该最后剂量保护机构包括第一构件（60），其可以在剂量期间沿第一方向旋转。 2在剂量分配期间选择和相反方向，联接到第一构件（60）和壳体（10）的第二构件（50），使得第二构件相对于第一构件（60）移动到第二构件 第一构件（60）旋转时的壳体（10）和在剂量分配期间相对于第一和第二构件（50,60）移动的第三构件（100）。 第二和第三成员（50,100）的基台防止增加所选择的剂量。

公开(公告)号：US20160136358A1

公开(公告)日：2016-05-19

申请号：US14905382

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315

CPC分类号： A61M5/31541 ,  A61M5/20 ,  A61M5/31528 ,  A61M5/31551 ,  A61M5/31593

摘要： The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament including a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device comprises a cartridge (80) containing liquid, preferably a medicament, a dosing element (40, 130), which rotates during dose selecting, a last dose nut (110) coupled to the dosing element (40, 130) during dose selecting such that rotation of the dosing element (40, 130) causes an axial movement of the last dose nut (110), and a stop element (137), which is provided on the dosing element (40, 130) and which blocks further movement of the last dose nut (110), if a dose is selected corresponding to the amount of liquid left in the cartridge (80). The device further comprises a last dose sleeve (120) rotationally coupled to the dosing element (40, 130) during dose selecting and rotationally de-coupled from the dosing element (40, 130) during dose dispensing.

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置，所述药物包括剂量限制器，用于防止剂量的设定超过药物递送装置的药筒中残留的液体量。 所述装置包括在剂量选择期间旋转的剂量元件（40,130），所述剂量容器包含液体，优选为药物，所述剂量元件在剂量选择期间与所述计量元件（40,130）相耦合的最后剂量螺母（110） 使得配量元件（40,130）的旋转导致最后剂量螺母（110）的轴向运动和设置在计量元件（40,130）上的止动元件（137），并且阻止进一步的运动 如果对应于留在盒（80）中的液体的量选择剂量，则最后剂量螺母（110）的位置。 该装置还包括在剂量分配期间在剂量选择期间旋转地联接到计量元件（40,130）的最后剂量套筒（120），并从定量元件（40,130）旋转地脱耦合。

公开(公告)号：US20160151580A1

公开(公告)日：2016-06-02

申请号：US14905393

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315

CPC分类号： A61M5/31551 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31536 ,  A61M5/31541 ,  A61M5/31545 ,  A61M5/31553 ,  A61M5/31583 ,  A61M2005/3126 ,  A61M2005/31518 ,  A61M2005/3154

摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge holder (20) for receiving a cartridge (170), a lead screw (30) and means (40, 90) for driving the lead screw (30) during dose dispensing. The lead screw (30) is coupled to the cartridge holder (20) such that the cartridge holder (20) is axially displaced with respect to the housing (10) and the lead screw (30) during dose dispensing.

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置。 该装置包括壳体（10），用于容纳盒（170）的盒保持器（20），用于在剂量分配期间驱动丝杠（30）的导螺杆（30）和装置（40,90）。 导螺杆（30）联接到药筒保持器（20），使得药筒保持器（20）在剂量分配期间相对于壳体（10）和丝杠（30）轴向移位。

公开(公告)号：US20160151574A1

公开(公告)日：2016-06-02

申请号：US14904737

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315

摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises at least one clicker mechanism (52, 64; 143, 153) for generating a haptic and/or audible feedback during dose selecting, wherein the clicker mechanism (143, 153) generates a different feed-back when selecting single units or multiples of single units.

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置。 所述装置包括用于在剂量选择期间产生触觉和/或听觉反馈的至少一个鸣叫机构（52,64; 143,153），其中，当选择单个单元时，所述答题机构（143,153）产生不同的反馈 单位数倍数。

公开(公告)号：US20160151572A1

公开(公告)日：2016-06-02

申请号：US14905390

申请日：2014-07-17

申请人： SANOFI

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315

CPC分类号： A61M5/3155 ,  A61M5/31528 ,  A61M5/31541 ,  A61M5/31548 ,  A61M5/31553 ,  A61M5/31578 ,  A61M5/31593 ,  A61M2005/2403 ,  A61M2005/3126

摘要： The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament including a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device comprises a housing (10, 20), a dose selector (140) for selecting a dose by rotation relative to the housing (10, 20), a dosing element (40, 130), and a releasable clutch (45, 143) for rotationally coupling the dosing element (40, 130) to the dose selector (140) during dose selecting and for rotationally decoupling the dosing element (40, 130) from the dose selector (140) during dose dispensing. The clutch comprises a male spline (45), a corresponding female spline (143) and a curved or inclined surface (142) which is orientated such that re-engagement of the clutch guides the male spline (45) into a predefined rotational orientation with respect to the female spline (143).

摘要翻译： 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置，所述药物包括剂量限制器，用于防止剂量的设定超过药物递送装置的药筒中残留的液体量。 所述装置包括壳体（10,20），用于通过相对于所述壳体（10,20）旋转来选择剂量的剂量选择器（140），配量元件（40,130）和可释放离合器（45,143） ），用于在剂量选择期间将给药元件（40,130）旋转耦合到剂量选择器（140），并且用于在剂量分配期间将计量元件（40,130）与剂量选择器（140,130）旋转地分离。 离合器包括阳花键（45），对应的雌花键（143）和弯曲或倾斜表面（142），其被定向成使得离合器的再接合将阳花键（45）引导成预定的旋转取向， 相对于雌花键（143）。

公开(公告)号：US10596323B2

公开(公告)日：2020-03-24

申请号：US14904737

申请日：2014-07-17

申请人： Sanofi

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315 ,  A61M5/31 ,  A61M5/24

摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises at least one clicker mechanism (52, 64; 143, 153) for generating a haptic and/or audible feedback during dose selecting, wherein the clicker mechanism (143, 153) generates a different feed-back when selecting single units or multiples of single units.

公开(公告)号：US10512731B2

公开(公告)日：2019-12-24

申请号：US14904739

申请日：2014-07-17

申请人： Sanofi

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/315 ,  A61M5/24 ,  A61M5/31 ,  A61M5/50

摘要： The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge (170) containing a medicament and a last dose protection mechanism for preventing the selection of a dose, which exceeds the amount of medicament left in a cartridge (170). This last dose protection mechanism comprises a first member (60), which is rotatable in a first direction during dose selecting and in the opposite direction during dose dispensing, a second member (50) coupled to the first member (60) and to the housing (10) such that the second member is moved relative to the first member (60) and to the housing (10) upon rotation of the first member (60) and a third member (100) which is moved relative to the first and second member (50, 60) during dose dispensing. Abutment of the second and third member (50, 100) prevents increasing the selected dose.

公开(公告)号：US10441721B2

公开(公告)日：2019-10-15

申请号：US14905080

申请日：2014-07-17

申请人： Sanofi

发明人： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC分类号： A61M5/31 ,  A61M5/315

摘要： The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a dosing element (40, 30), which rotates in a first direction during dose selecting and rotates in a second, opposite direction during dose dispensing, and a display (60) for indicating the selected dose. The display (60) comprises at least one belt (61, 62) having symbols for indicating the selected dose and being coupled to the dosing element (40, 130) such that a rotation of the dosing element (40, 130) spools the belt (61, 62).