公开(公告)号：US06960208B2

公开(公告)日：2005-11-01

申请号：US10611222

申请日：2003-06-30

Applicant: George Bourne ,  Robert Rioux ,  Robert Garabedian

Inventor： George Bourne ,  Robert Rioux ,  Robert Garabedian

IPC: A61B18/14 ,  A61B18/18

CPC classification number: A61B18/1487 ,  A61B2018/00565

Abstract: An apparatus for delivering energy to a target site within bone includes a hollow needle extending from a handle that terminates in a tissue piercing distal tip. A drill within a lumen of the needle is extendable beyond the distal tip, and includes a cutting element and an electrically conductive region. An RF generator may be coupled to the drill for delivering energy to the electrically conductive region, and a driver or actuator may be coupled to the drill for rotating and/or advancing the drill axially. During use, the needle is inserted through a patient's skin to a hard tissue structure, e.g., a bone, including a target site therein, e.g., a tumor. The drill is advanced from the needle, a hole is drilled into the bone until the drill reaches the tumor, and electrical energy is delivered via the electrically conductive region to destroy the tumor.

Abstract translation: 用于将能量递送到骨骼内的目标部位的装置包括从终止于组织穿刺远侧末端的手柄延伸的中空针。 针内腔内的钻孔可延伸超过远侧末端，并且包括切割元件和导电区域。 RF发生器可以耦合到钻头以将能量传递到导电区域，并且驱动器或致动器可以联接到钻头以使钻头轴向旋转和/或前进。 在使用期间，将针穿过患者的皮肤插入硬组织结构，例如骨，包括其中的靶部位，例如肿瘤。 钻头从针头前进，将钻孔钻到骨头中，直到钻头到达肿瘤，电能通过导电区域输送以破坏肿瘤。

公开(公告)号：US20050240174A1

公开(公告)日：2005-10-27

申请号：US10831244

申请日：2004-04-23

Applicant: Christopher Pearson ,  Robert Garabedian ,  Robert Rioux

Inventor： Christopher Pearson ,  Robert Garabedian ,  Robert Rioux

IPC: A61B18/14 ,  A61N1/06 ,  A61B18/18

CPC classification number: A61B18/1477 ,  A61B2018/143 ,  A61B2018/1432

Abstract: An invasive medical device for delivery radio frequency energy to a target tissue region includes an elongate delivery cannula having a lumen in communication with a distal opening. A deployment member is positioned and longitudinally movable in the lumen. An array of electrode elements are secured to a distal end of the deployment member, the deployment member being movable from a delivery position, in which the electrode elements are positioned within the lumen, to a deployed position, in which the electrode elements extend distally out of the cannula distal opening. A sealing member formed from a biocompatible material sufficiently rigid to penetrate solid body tissue partially extends from, and substantially seals, the distal cannula opening when the deployment member is in the delivery position. By way of examples, the sealing member may be carried on a distal end of the deployment member, or on a separately movable deployment member, or frictionally fit in the cannula distal opening.

Abstract translation: 用于将射频能量传送到目标组织区域的侵入性医疗装置包括具有与远端开口连通的内腔的细长输送套管。 展开构件在内腔中定位和纵向移动。 电极元件的阵列固定到展开构件的远端，展开构件可从电子元件位于内腔内的输送位置移动到展开位置，电极元件向远侧延伸 的套管远端开口。 当展开构件处于输送位置时，由足够刚性以穿透实体组织的生物相容性材料形成的密封构件部分延伸并且基本上密封远端插管开口。 作为示例，密封构件可以承载在展开构件的远端上，或者在可单独移动的展开构件上承载，或摩擦地配合在套管远侧开口中。

公开(公告)号：US20050059852A1

公开(公告)日：2005-03-17

申请号：US10665110

申请日：2003-09-16

Applicant: Robert Rioux ,  Robert Garabedian

Inventor： Robert Rioux ,  Robert Garabedian

IPC: A61N1/40 ,  A61N2/02 ,  A61N2/08 ,  A61N2/00

CPC classification number: A61N1/406 ,  A61N2/02

Abstract: A system for treating tissue includes a source of conductive and/or magnetic beads, a first member, e.g., a catheter or cannula, coupled to the source of magnetic beads, and a second member, e.g., a catheter or cannula, carrying a magnet on its distal end. The system is used for ablating or otherwise treating tissue within a target tissue region including a blood vessel contacting or passing therethrough. Magnetic beads are introduced into the target tissue region, e.g., using the first member, and a magnetic field is generated within the target tissue region, e.g., using the second member, to cause the magnetic beads to migrate towards a wall of the vessel. Energy is delivered into the target tissue region, e.g., to heat tissue therein, and the magnetic beads may attenuate or enhance treatment of tissue adjacent to the vessel.

Abstract translation: 用于治疗组织的系统包括导电和/或磁珠的源，耦合到磁珠源的第一构件，例如导管或插管，以及携带磁体的第二构件，例如导管或套管 在它的远端。 该系统用于烧蚀或以其他方式处理包括接触或穿过其中的血管的靶组织区域内的组织。 将磁珠引入目标组织区域，例如使用第一构件，并且例如使用第二构件在目标组织区域内产生磁场，使磁珠朝向容器的壁迁移。 能量被递送到目标组织区域中，例如以加热其中的组织，并且磁珠可以减弱或增强对与血管相邻的组织的治疗。

公开(公告)号：US20140114315A1

公开(公告)日：2014-04-24

申请号：US14061641

申请日：2013-10-23

Applicant: Roy LEGUIDLEGUID ,  Robert Garabedian ,  Michael P. WALLACE

Inventor： Roy LEGUIDLEGUID ,  Robert Garabedian ,  Michael P. WALLACE

IPC: A61B17/16

CPC classification number: A61B17/1671 ,  A61B17/149 ,  A61B17/1659

Abstract: Tissue modification devices, methods of using them, and devices, systems and methods of adapting them to form tissue modification devices.

Abstract translation: 组织修饰装置，使用它们的方法，以及适应它们以形成组织修饰装置的装置，系统和方法。

公开(公告)号：US08632538B2

公开(公告)日：2014-01-21

申请号：US13423205

申请日：2012-03-17

Applicant: Christopher Pearson ,  Robert Garabedian ,  Robert F. Rioux

Inventor： Christopher Pearson ,  Robert Garabedian ,  Robert F. Rioux

IPC: A61B18/18

CPC classification number: A61B18/1477 ,  A61B2018/143 ,  A61B2018/1432

Abstract: A medical device for delivering RF energy to a target tissue region includes an elongate delivery cannula having a lumen in communication with a distal opening. A deployment member is positioned and longitudinally movable in the lumen. An array of electrode elements are secured to a distal end of the deployment member, the deployment member being movable from a delivery position, in which the electrode elements are positioned within the lumen, to a deployed position, in which the electrode elements extend distally out of the cannula distal opening. A sealing member formed from a bio-compatible material sufficiently rigid to penetrate solid body tissue partially extends from, and substantially seals, the distal cannula opening when the deployment member is in the delivery position.

Abstract translation: 用于将RF能量递送到目标组织区域的医疗装置包括具有与远端开口连通的内腔的细长输送套管。 展开构件在内腔中定位和纵向移动。 电极元件的阵列固定到展开构件的远端，展开构件可从电子元件位于内腔内的输送位置移动到展开位置，电极元件向远侧延伸 的套管远端开口。 当展开构件处于输送位置时，由足够刚性以穿透实体组织的生物相容性材料形成的密封构件部分延伸并且基本上密封远侧插管开口。

公开(公告)号：US20120191003A1

公开(公告)日：2012-07-26

申请号：US13437214

申请日：2012-04-02

Applicant: Robert Garabedian ,  Benjamin Kao-Shing Sun ,  Roy Leguidleguid ,  Michael P. Wallace

Inventor： Robert Garabedian ,  Benjamin Kao-Shing Sun ,  Roy Leguidleguid ,  Michael P. Wallace

IPC: A61B5/05

CPC classification number: A61N1/0551 ,  A61B5/04001 ,  A61B5/0488 ,  A61B5/1107 ,  A61B5/4519 ,  A61B5/4893 ,  A61B17/149 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/320016 ,  A61B17/7092 ,  A61B17/8897 ,  A61B2017/32006 ,  A61B2562/0261 ,  A61B2562/046

Abstract: Described herein are bimanually controlled neural localization devices capable of determining if a nerve is nearby a region of the device. In general, the device may include at least two electrodes including an anode in electrical communication with a anodal conductor and a cathode in electrical communication with a cathodal conductor. The device may further include a flexible elongate body, wherein the flexible elongate body has an axial length, a width and a thickness, wherein the axial length is greater than the width, and the width is greater than the thickness and is greater than a width of the at least two electrodes. The at least two electrodes may be disposed substantially in-line and centered along the length of the elongate body. In some embodiments, the device may further include a guidewire coupler at the distal end region of the elongate body.

Abstract translation: 这里描述的是能够确定神经是否在装置的区域附近的双手控制的神经定位装置。 通常，该装置可以包括至少两个电极，包括与阳极导体电连通的阳极和与阴极导体电连通的阴极。 该装置还可以包括柔性细长主体，其中柔性细长主体具有轴向长度，宽度和厚度，其中轴向长度大于宽度，并且宽度大于厚度并且大于宽度 的至少两个电极。 所述至少两个电极可以沿着细长主体的长度基本上一直排列并居中。 在一些实施例中，该装置还可包括在细长主体的远端区域处的导丝联接器。

公开(公告)号：US07993335B2

公开(公告)日：2011-08-09

申请号：US11550374

申请日：2006-10-17

Applicant: Robert F. Rioux ,  Robert Garabedian

Inventor： Robert F. Rioux ,  Robert Garabedian

IPC: A61B18/14

CPC classification number: A61B18/1477 ,  A61B2018/00065 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2218/002 ,  C04B38/0067 ,  C04B2111/00836 ,  C04B2111/94 ,  C04B35/00 ,  C04B38/0054

Abstract: Ablation probes are provided for perfusing the tissue, while the tissue is ablated. The ablation probe comprises an elongated shaft and an ablative element, such as a needle electrode. The ablation probe further comprises a lumen that extends through the probe shaft, which will be used to deliver an fluid to the distal end of the probe shaft for perfusion into the surrounding tissue. The ablation probe further comprises a porous structure that is associated with the distal end of the shaft in fluid communication with the lumen. For example, the distal end of the shaft, or the entirety of the shaft, can be composed of the porous structure. Or, if the ablative element is an electrode, the electrode can be composed of the porous structure. Because the pores within the porous structure are pervasive, the fluid will freely flow out into the tissue notwithstanding that some of the pores may become clogged.

Abstract translation: 提供消融探针用于灌注组织，同时组织被消融。 消融探针包括细长轴和消融元件，例如针电极。 消融探针还包括延伸穿过探针轴的内腔，其将用于将流体输送到探针轴的远端以灌注到周围组织中。 消融探针还包括与轴的远端相关联的多孔结构，其与内腔流体连通。 例如，轴的远端或轴的整体可以由多孔结构构成。 或者，如果烧蚀元件是电极，则电极可以由多孔结构构成。 因为多孔结构内的孔是普遍的，所以即使一些孔隙可能被堵塞，流体也可以自由流出到组织中。

公开(公告)号：US20080027426A1

公开(公告)日：2008-01-31

申请号：US11867668

申请日：2007-10-04

Applicant: Amy Kelly ,  Steven Landreville ,  Robert Garabedian

Inventor： Amy Kelly ,  Steven Landreville ,  Robert Garabedian

IPC: A61B18/14

CPC classification number: A61B18/1477 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/0016 ,  A61B2018/00196 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1475

Abstract: A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.

Abstract translation: 提供用于烧伤组织的表面电极。 所述表面电极包括基底，从所述基底的表面延伸可调节距离的多个组织穿透针电极以及耦合到所述多个针电极的电接口。 针电极的可调性允许针电极穿透组织的深度被调整。

公开(公告)号：US20060129203A1

公开(公告)日：2006-06-15

申请号：US11010232

申请日：2004-12-10

Applicant: Robert Garabedian ,  Michael Wallace ,  Gary Heit

Inventor： Robert Garabedian ,  Michael Wallace ,  Gary Heit

IPC: A61N1/05

CPC classification number: A61N1/0531 ,  A61N1/0539 ,  A61N1/36082

Abstract: Methods and kits for delivering an electrode lead into the head of a patient are provided. A burr hole is formed within the cranium of the patient, and an electrode lead is threaded through the burr hole. The electrode lead is then placed in a pre-shaped two-dimensional geometry between the cranium and cortical brain tissue of the patient. An access anchor may be mounted into the burr hole to facilitate introduction and removal of the electrode lead and other devices. In some circumstances, it may be desirable to separate the dura mater overlying the cortical brain tissue from the cortical brain tissue to create a pocket in which the electrode lead may be manipulated. In this case, a tissue layer dissection device can be introduced through the burr hole, operated to separate the dura mater from the cranium, and then removed from the burr hole. In one embodiment, the dissection device comprises a balloon that can be inflated to separate the dura mater and cranium, and then deflated prior to removing the dissection device from the burr hole.

Abstract translation: 提供了用于将电极引线输送到患者头部的方法和套件。 在患者的颅骨内形成有钻孔，电极引线穿过毛刺孔。 然后将电极引线置于患者的颅骨和皮质脑组织之间的预先形状的二维几何形状中。 可以将入口锚固件安装到钻孔中以便于引入和移除电极引线和其它装置。 在某些情况下，可能需要将覆盖皮质脑组织的硬膜与皮层脑组织分离，以产生可以操纵电极引线的口袋。 在这种情况下，可以通过毛刺孔引入组织层解剖装置，操作以将硬脑膜与头颅分开，然后从毛刺孔中取出。 在一个实施例中，解剖装置包括可以充气以分离硬脑膜和颅骨的气囊，然后在从毛刺孔移除解剖装置之前放气。

公开(公告)号：US20060058854A1

公开(公告)日：2006-03-16

申请号：US10941382

申请日：2004-09-14

Applicant: Robert Abrams ,  Michael Wallace ,  Robert Garabedian

Inventor： Robert Abrams ,  Michael Wallace ,  Robert Garabedian

IPC: A61N1/18

CPC classification number: A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

Abstract: A method of treating a disorder of a patient, such as a neurological disorder, is provided. The method comprises intravascularly delivering at least one of a stimulation lead and a sensing lead within the head of the patient. For example, one or both of the leads can be delivered into the patient's head via the circulatory system (e.g., vein or artery) or the ventricular system (e.g., through the intrathecal space of the spine). The method further comprises sensing a physiological event associated with the disorder (e.g., physiological electrical activity, a blood parameter, or intracranial pressure) using the sensing lead, and stimulating neural tissue with the stimulation lead in response to the sensed physiological event.

Abstract translation: 提供了治疗患者疾病如神经障碍的方法。 该方法包括在患者头部内血管内输送刺激引线和感测引线中的至少一个。 例如，一个或两个引线可以通过循环系统（例如静脉或动脉）或心室系统（例如，通过脊柱的鞘内空间）递送到患者的头部。 该方法还包括使用感测引线感测与病症相关的生理事件（例如，生理电活动，血液参数或颅内压），以及响应感测的生理事件刺激刺激引线的神经组织。