公开(公告)号：US20240201178A1

公开(公告)日：2024-06-20

申请号：US18284783

申请日：2022-03-31

Applicant: RANDOX LABORATORIES LTD. ,  RANDOX TEORANTA

Inventor： Peter Fitzgerald ,  John Victor Lamont ,  Ivan McConnell ,  Ciaran Richardson ,  Philip Lowry ,  Jim Curry

IPC: G01N33/543 ,  G01N33/68

CPC classification number: G01N33/54353 ,  G01N33/54393 ,  G01N33/6857 ,  G01N2650/00

Abstract: The present invention relates to improved detection assays via the utilisation of a substrate with an analyte immobilised on its surface by means of a linking agent and a cross-linker. The present invention also relates to a method of producing a substrate for use in detection assays and a method of detecting an analyte using said substrate.

公开(公告)号：US20220349882A1

公开(公告)日：2022-11-03

申请号：US17630101

申请日：2020-07-26

Applicant: Randox Laboratories Ltd ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  Ivan McConnell ,  Ciaran Richardson ,  John Lamont

IPC: G01N33/543 ,  G01N33/569

Abstract: The current invention provides a multiplex method for screening bovine samples for antibodies against several important pathogens. These pathogens include Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpesvirus-1 (BoHV-1), Mycobacterium paratuberculosis (MAP), Leptospira species, Neospora caninum and Fasciola hepatica. This multiplex screening is enabled by substrates with immobilized pathogen antigens and offer multiple advantages for the routine testing of farm animals.

公开(公告)号：US20190004050A1

公开(公告)日：2019-01-03

申请号：US16065646

申请日：2016-12-23

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  John Lamont ,  Ciaran Richardson

IPC: G01N33/574

Abstract: The present invention describes methods of determining the glycosylation signature and determining the level of a protein in a sample obtained from a patient.The present invention also describes use of a patient protein glycosylation profile to identify the presence or absence of a disease in subjects.

公开(公告)号：US20160216278A1

公开(公告)日：2016-07-28

申请号：US15026577

申请日：2014-10-06

Applicant: RANDOX TEORANTA

Inventor： Ivan McConnell ,  Ciaran Richardson ,  John Lamont ,  Stephen Peter Fitzgerald

IPC: G01N33/68

Abstract: The present invention provides methods and solid state devices for detecting and staging chronic kidney disease in a patient, where the levels of biomarkers in a sample obtained from a patient are elevated or reduced compared to the levels in a sample obtained from healthy subject.The invention also relates to the use of methods and solid state devices for measurement of specific biological markers for determining the efficacy of a treatment for chronic kidney disease and for determining a drug treatment protocol for a subject suffering from chronic kidney disease.

Abstract translation: 本发明提供了用于检测和分期患者慢性肾脏疾病的方法和固态装置，其中从患者获得的样品中的生物标志物的水平与从健康受试者获得的样品中的水平相比升高或降低。 本发明还涉及方法和固态装置用于测量特异性生物标志物以确定慢性肾脏疾病治疗功效以及确定患有慢性肾脏疾病的受试者的药物治疗方案的用途。