公开(公告)号：US20070083160A1

公开(公告)日：2007-04-12

申请号：US11316411

申请日：2005-12-21

Applicant: W. Hall ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard King

Inventor： W. Hall ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard King

IPC: A61M37/00

CPC classification number: A61B5/157 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B2560/0271 ,  A61M5/14212 ,  A61M2230/20

Abstract: In certain embodiments, a body fluid analyzing system includes a body fluid analyzer configured to be in fluid communication with a body fluid within a patient. The body fluid analyzing system further includes a communication interface configured to provide communication between the body fluid analyzer and a data system which includes at least one data file. The body fluid analyzer is configured to access the at least one data file via the communication interface.

Abstract translation: 在某些实施例中，体液分析系统包括体液分析器，其构造成与患者体内的体液流体连通。 体液分析系统还包括被配置为提供体液分析器与包括至少一个数据文件的数据系统之间的通信的通信接口。 体液分析器被配置为经由通信接口访问至少一个数据文件。

公开(公告)号：US20060004267A1

公开(公告)日：2006-01-05

申请号：US11173768

申请日：2005-07-01

Applicant: Peter Rule ,  James Braig ,  Philip Hartstein

Inventor： Peter Rule ,  James Braig ,  Philip Hartstein

IPC: A61B5/00

CPC classification number: B01L3/5023 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1491 ,  B01L3/5027 ,  B01L3/508 ,  B01L2200/027 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/03 ,  G01N21/8483 ,  G01N2021/0346

Abstract: A spectroscopic sample holder comprises a microporous sheet. The microporous sheet has a top surface, a bottom surface substantially parallel to the top surface, and at least one side surface oriented substantially perpendicular to the top and bottom surfaces. The side surface forms an exposed transit opening configured to contact a material sample and distribute the contacted material sample into the microporous sheet. The spectroscopic sample holder further comprises a first planar support member positioned on, and substantially parallel to, the top surface of the microporous sheet. The spectroscopic sample holder further comprises a second planar support member positioned on the bottom surface of the microporous sheet, and oriented substantially parallel to the first planar support member.

Abstract translation: 光谱样品架包括微孔片。 微孔片具有基本平行于顶表面的顶表面，底表面以及基本上垂直于顶表面和底表面取向的至少一个侧表面。 侧表面形成暴露的转移开口，其构造成接触材料样品并将接触的材料样品分配到微孔板中。 光谱样品架还包括位于微孔板的顶表面上且基本上平行于微孔板的顶表面的第一平面支撑构件。 光谱样品架还包括位于微孔板的底表面上并基本上平行于第一平面支撑构件定向的第二平面支撑构件。

公开(公告)号：US06959211B2

公开(公告)日：2005-10-25

申请号：US10213730

申请日：2002-08-06

Applicant: Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian M. Cortella ,  Heidi M. Smith ,  Roger O. Herrera ,  Kenneth G. Witte ,  Philip C. Hartstein ,  Mark D. Agostino

Inventor： Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian M. Cortella ,  Heidi M. Smith ,  Roger O. Herrera ,  Kenneth G. Witte ,  Philip C. Hartstein ,  Mark D. Agostino

IPC: A61B5/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/35

CPC classification number: A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/6824 ,  G01J3/0286 ,  G01J3/0291 ,  G01N21/01 ,  G01N21/35 ,  G01N2021/0389 ,  G01N2201/021 ,  G01N2201/0245

Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.

Abstract translation: 提供了一种用于无创光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。 在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。 当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。 当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

公开(公告)号：US09848821B2

公开(公告)日：2017-12-26

申请号：US13162315

申请日：2011-06-16

Applicant: Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/00 ,  B65D33/00 ,  B65D81/00 ,  A61D5/00 ,  A61M1/00 ,  A61M27/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/153 ,  A61B5/157 ,  A61M5/14 ,  A61M5/172 ,  A61M5/145 ,  A61M5/142

CPC classification number: A61B5/4839 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/157 ,  A61B5/6866 ,  A61M5/1415 ,  A61M5/1452 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/201

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.

公开(公告)号：US09414782B2

公开(公告)日：2016-08-16

申请号：US13619825

申请日：2012-09-14

Applicant: James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

Inventor： James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

IPC: A61M5/172 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G06F19/00 ,  A61M5/168 ,  A61M5/14 ,  A61M5/142

CPC classification number: A61B5/4839 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/7475 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/3303 ,  A61M2209/084 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

公开(公告)号：US08412293B2

公开(公告)日：2013-04-02

申请号：US12174501

申请日：2008-07-16

Applicant: Peter Rule

Inventor： Peter Rule

IPC: A61K5/00

CPC classification number: A61B5/150992 ,  A61B5/029 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61M2005/1404 ,  G01N21/359 ,  G06F19/00

Abstract: Systems and methods for determining a physiological parameter in a patient are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a fluid sample received from a patient, a medical sensor configured to measure second analyte data in the patient, and a processor configured to receive the first analyte data and the second analyte data and to determine a physiological parameter based at least in part on the first analyte data and the second analyte data. In certain such embodiments, the medical sensor may be a pulse oximeter, and the physiological parameter may include a cardiovascular parameter including, for example, cardiac output.

Abstract translation: 提供了用于确定患者生理参数的系统和方法。 在某些实施例中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品中的第一分析物数据，被配置为测量患者中的第二分析物数据的医学传感器，以及被配置为接收第一分析物数据 和第二分析物数据，并且至少部分地基于第一分析物数据和第二分析物数据来确定生理参数。 在某些这样的实施例中，医疗传感器可以是脉搏血氧计，并且生理参数可以包括包括例如心输出量的心血管参数。

公开(公告)号：US20120203089A1

公开(公告)日：2012-08-09

申请号：US12966881

申请日：2010-12-13

Applicant: Peter Rule ,  Gil Rivas

Inventor： Peter Rule ,  Gil Rivas

IPC: A61B5/145

CPC classification number: G06F19/3412 ,  A61B5/0002 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/4839 ,  A61B5/7435 ,  A61B5/7475 ,  A61B2560/0271 ,  A61B2560/029 ,  A61B2560/0437 ,  A61M5/1415 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/6072 ,  A61M2230/201 ,  G01N21/274 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/359 ,  G01N33/49 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3468 ,  G06F19/3487 ,  G16H15/00 ,  G16H40/40

Abstract: Some embodiments provide a system for synchronizing and configuring monitoring devices. In some embodiments, a patient monitoring device settings module is configured to automatically provide configuration settings to a plurality of patient monitoring devices. A monitoring device data module is configured to receive measurement data from at least one of the patient monitoring devices. An electronic medical records system interface is configured to provide patient data at least partially derived from the received measurement data to an electronic medical records system. A patient records interface is configured to provide patient data to at least one of the patient monitoring devices.

Abstract translation: 一些实施例提供用于同步和配置监视设备的系统。 在一些实施例中，患者监视设备设置模块被配置为自动地向多个患者监视设备提供配置设置。 监视设备数据模块被配置为从至少一个患者监视设备接收测量数据。 电子医疗记录系统接口被配置为将至少部分地从接收到的测量数据导出的患者数据提供给电子病历系统。 患者记录界面被配置为向至少一个患者监视设备提供患者数据。

公开(公告)号：US20100249547A1

公开(公告)日：2010-09-30

申请号：US12815372

申请日：2010-06-14

Applicant: James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: A61B5/15

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US07785258B2

公开(公告)日：2010-08-31

申请号：US11316523

申请日：2005-12-21

Applicant: James R. Braig ,  Peter Rule

Inventor： James R. Braig ,  Peter Rule

IPC: A61B5/00 ,  A61B5/05 ,  C12M1/34 ,  C12M3/00 ,  C12M1/36 ,  C12M1/00

CPC classification number: G06F19/3468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M2230/20 ,  G01N21/274 ,  G01N21/35 ,  G01N2201/1293 ,  G06F19/00

Abstract: In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.

Abstract translation: 在某些实施例中，维持患者健康的方法使用分析物检测系统。 分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。 该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。 该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。

公开(公告)号：US20090131861A1

公开(公告)日：2009-05-21

申请号：US12249831

申请日：2008-10-10

Applicant: James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

Inventor： James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

IPC: A61M5/172

CPC classification number: A61B5/4839 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/7475 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/3303 ,  A61M2209/084 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g. insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

Abstract translation: 公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。 本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。 治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。