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公开(公告)号：US12174105B2
公开(公告)日：2024-12-24
申请号：US18379775
申请日：2023-10-13
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , J. Paul Robinson , Keegan Hernandez
IPC: G01N15/14 , G01N15/1429 , G01N15/1434
Abstract: A system is described wherein a plurality of lasers are used to irradiate particles in a flow cytometer's flow stream. In certain embodiments, a light source having a plurality of lasers configured for irradiation of a flow stream are disclosed where discrete intervals of irradiation by one or more discretely activated lasers are triggered by irradiation of one or more particles in the flow stream with one or more continuously on lasers.
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Patent Agency Ranking
公开(公告)号：US12050130B2
公开(公告)日：2024-07-30
申请号：US18542717
申请日：2023-12-17
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A measurement system is disclosed which includes a vessel configured to suspend molecules of interest therein, optical sources configured to excite the molecules of interest by an excitation light activated and deactivated in a stepwise fashion, during the activation, the sources activated according to a pulse train, the molecules of interest emitting emission light in response to being excited by the excitation light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the molecules of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the molecules of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
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公开(公告)号：US20240133740A1
公开(公告)日：2024-04-25
申请号：US18542717
申请日：2023-12-17
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A measurement system is disclosed which includes a vessel configured to suspend molecules of interest therein, optical sources configured to excite the molecules of interest by an excitation light activated and deactivated in a stepwise fashion, during the activation, the sources activated according to a pulse train, the molecules of interest emitting emission light in response to being excited by the excitation light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the molecules of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the molecules of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
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公开(公告)号：US20240125790A1
公开(公告)日：2024-04-18
申请号：US18519724
申请日：2023-11-27
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , J. Paul Robinson
IPC: G01N33/58 , B01L3/00 , G01N15/14 , G01N15/1429 , G01N15/1434 , G01N33/49 , G01N35/00
CPC classification number: G01N33/582 , B01L3/00 , G01N15/1427 , G01N15/1429 , G01N15/1434 , G01N33/4915 , G01N35/00069 , G01N21/645
Abstract: A measurement system is disclosed which includes a spot-traversal system for causing relative motion between a sample and an irradiation spot in a first direction, wherein the sample includes one or more fluorescent markers having respective fluorescence wavelengths, a gating system configured to provide a gating signal based at least in part on resultant light substantially at a wavelength of the irradiation spot, and an optical detection system configured to detect fluorescent light from at least some of the fluorescent markers irradiated by the irradiation spot, and provide detection signal(s) representing the fluorescent light detected concurrently with a gate-open condition of the gating signal.
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公开(公告)号：US11852537B2
公开(公告)日：2023-12-26
申请号：US18130867
申请日：2023-04-04
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A flow cytometry measurement system is disclosed which includes a flow chamber configured to flow particles of interest in a flow stream, one or more optical sources configured to excite the particles of interest by an excitation light activated and deactivated according to a pulse train thus causing particles of interest emitting emission light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the particles of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the particles of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
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公开(公告)号：US11835525B2
公开(公告)日：2023-12-05
申请号：US16840220
申请日：2020-04-03
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , J. Paul Robinson
CPC classification number: G01N33/582 , B01L3/00 , G01N15/1427 , G01N15/1429 , G01N15/1434 , G01N33/4915 , G01N35/00069 , G01N15/1456 , G01N15/1459 , G01N15/1484 , G01N21/645 , G01N2035/00881 , G01N2201/1045
Abstract: A measurement system includes a system for causing relative motion between a sample and an irradiation spot. The sample includes fluorescent markers having respective wavelengths. A gating system provides a gating signal based at least in part on resultant light substantially at an irradiation wavelength. A detection system detects fluorescent light from the irradiated markers and provides detection signals representing the fluorescent light detected concurrently with a gate-open signal. In some examples, the detection system detects fluorescent light at multiple wavelengths and provides respective detection signals. A spectral discriminator arranged optically between the sample and the detection system receives the fluorescent light from the sample and provides respective fluorescent light at the wavelengths to the detection system. A flow cytometer can spectrally disperse resultant fluorescent light and measure the wavelengths separately. Light from a sample disposed over a reflective phase grating can be dispersed, measured, and gated.
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