公开(公告)号：US11345739B2

公开(公告)日：2022-05-31

申请号：US16820844

申请日：2020-03-17

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  G01N33/53 ,  G01N33/574 ,  A61P35/00 ,  C12N15/85 ,  C07K14/705 ,  G01N33/68 ,  C07K14/71 ,  A61K38/39 ,  G01N33/566

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US11299534B2

公开(公告)日：2022-04-12

申请号：US16821064

申请日：2020-03-17

Applicant: Janssen Biotech, Inc.

Inventor： Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/00 ,  C07K14/52 ,  C07K14/78 ,  G01N33/569 ,  G01N33/68 ,  G01N33/566 ,  A61K51/08 ,  G01N33/53 ,  A61K49/00 ,  G01N33/574

Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.

公开(公告)号：US20180162929A1

公开(公告)日：2018-06-14

申请号：US15840303

申请日：2017-12-13

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  C07K14/705 ,  C12N15/85 ,  A61P35/00

Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：US20180162927A1

公开(公告)日：2018-06-14

申请号：US15839915

申请日：2017-12-13

Applicant: Janssen Biotech, Inc.

Inventor： Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07K14/78 ,  G01N33/569 ,  G01N33/68

Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.