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公开(公告)号：US07541180B2
公开(公告)日：2009-06-02
申请号：US10479649
申请日：2002-05-30
Applicant: Nicholas Valiante
Inventor： Nicholas Valiante
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/53 , C07K14/395 , C07K14/70521 , C07K19/00 , C07K2319/00 , C12N2770/24222
Abstract: A dimeric protein comprising a first fusion protein and a second fusion protein, wherein the first fusion protein comprises a targeting domain, a leucine zipper domain, and an antigen; and wherein the second fusion protein comprises a targeting domain, a leucine zipper domain, and optionally an antigen. Nucleic acid vectors encoding proteins of the invention are provided, particularly for use in nucleic acid vaccination.
Abstract translation: 包含第一融合蛋白和第二融合蛋白的二聚蛋白，其中所述第一融合蛋白包含靶向结构域，亮氨酸拉链结构域和抗原; 并且其中所述第二融合蛋白包含靶向结构域，亮氨酸拉链结构域和任选的抗原。 提供编码本发明蛋白质的核酸载体，特别是用于核酸疫苗接种。
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公开(公告)号：US20100226931A1
公开(公告)日：2010-09-09
申请号：US11630551
申请日：2005-06-24
Applicant: Nicholas Valiante , Feng Xu , Joel B. Silver
Inventor： Nicholas Valiante , Feng Xu , Joel B. Silver
CPC classification number: A61K39/39 , C12N2710/16611 , C12N2740/15011 , C12N2770/24211 , Y02A50/388 , Y02A50/466 , Y02A50/484
Abstract: Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed. In a preferred embodiment benzopyrimidine derivatives such as ZD-6474, MLN-518, lapatinib, gefitinib or erlotinib are used.
Abstract translation: 刺激免疫反应并用3,4-二（1H-吲哚-3-基）-1H-吡咯-2,5-二酮，星形孢菌素类似物，衍生化哒嗪，色烯-4-酮，吲哚啉酮 ，喹唑啉，核苷类似物和其他小分子。 在优选的实施方案中，使用苯并嘧啶衍生物如ZD-6474，MLN-518，拉帕替尼，吉非替尼或厄洛替尼。
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公开(公告)号：US20100098718A1
公开(公告)日：2010-04-22
申请号：US12455444
申请日：2009-06-01
Applicant: Nicholas Valiante
Inventor： Nicholas Valiante
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/53 , C07K14/395 , C07K14/70521 , C07K19/00 , C07K2319/00 , C12N2770/24222
Abstract: A dimeric protein comprising a first fusion protein and a second fusion protein, wherein the first fusion protein comprises a targeting domain, a leucine zipper domain, and an antigen; and wherein the second fusion protein comprises a targeting domain, a leucine zipper domain, and optionally an antigen. Nucleic acid vectors encoding proteins of the invention are provided, particularly for use in nucleic acid vaccination.
Abstract translation: 包含第一融合蛋白和第二融合蛋白的二聚蛋白，其中所述第一融合蛋白包含靶向结构域，亮氨酸拉链结构域和抗原; 并且其中所述第二融合蛋白包含靶向结构域，亮氨酸拉链结构域和任选的抗原。 提供编码本发明蛋白质的核酸载体，特别是用于核酸疫苗接种。
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公开(公告)号：US20090155306A1
公开(公告)日：2009-06-18
申请号：US11988895
申请日：2006-07-15
Applicant: Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
Inventor： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
Abstract: A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen.
Abstract translation: 用于鉴定作为宿主生物体中佐剂的多肽的方法。 本发明进一步提供了包含所述多肽并任选进一步包含抗原的佐剂组合物。
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公开(公告)号：US07521062B2
公开(公告)日：2009-04-21
申请号：US10748071
申请日：2003-12-29
Applicant: Paul A. Barsanti , Nathan Brammeier , Anthony Diebes , Liana Marie Lagniton , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Casey Philbin , Nicholas Valiante , Allan S. Wagman , Weibo Wang , Amy J. Weiner
Inventor： Paul A. Barsanti , Nathan Brammeier , Anthony Diebes , Liana Marie Lagniton , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Casey Philbin , Nicholas Valiante , Allan S. Wagman , Weibo Wang , Amy J. Weiner
IPC: A61K39/00 , A61K31/40 , A61K31/44 , A61K31/175 , A61K39/095 , A61K45/00
CPC classification number: C07D207/335 , A61K31/175 , A61K39/39 , A61K2039/55511 , C07D207/06 , C07D207/09 , C07D207/14 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04 , A61K2300/00
Abstract: The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.
Abstract translation: 本发明涉及新型免疫增强剂，新型疫苗佐剂，新化合物和药物组合物，通过施用化合物治疗病毒感染（包括HCV）的新方法，以及通过施用化合物调节免疫应答的新方法。
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Patent Agency Ranking
公开(公告)号：USD564614S1
公开(公告)日：2008-03-18
申请号：US29270488
申请日：2006-12-26
Applicant: Nicholas Valiante
Designer： Nicholas Valiante
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公开(公告)号：US20050069555A1
公开(公告)日：2005-03-31
申请号：US10748071
申请日：2003-12-29
Applicant: Paul Barsanti , Nathan Brammeier , Anthony Diebes , Liana Lagniton , Simon Ng , Zhi-Jie Ni , Keith Pfister , Casey Philbin , Nicholas Valiante , Allan Wagman , Weibo Wang , Amy Weiner
Inventor： Paul Barsanti , Nathan Brammeier , Anthony Diebes , Liana Lagniton , Simon Ng , Zhi-Jie Ni , Keith Pfister , Casey Philbin , Nicholas Valiante , Allan Wagman , Weibo Wang , Amy Weiner
IPC: A61K20060101 , A61K6/00 , A61K31/175 , A61K31/40 , A61K31/44 , A61K39/00 , A61K39/39 , A61P31/12 , C07D207/06 , C07D207/09 , C07D207/14 , C07D207/32 , C07D207/335 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/10 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D413/10 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04
CPC classification number: C07D207/335 , A61K31/175 , A61K39/39 , A61K2039/55511 , C07D207/06 , C07D207/09 , C07D207/14 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04 , A61K2300/00
Abstract: The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.
Abstract translation: 本发明涉及新型免疫增强剂，新型疫苗佐剂，新化合物和药物组合物，通过施用化合物治疗病毒感染（包括HCV）的新方法，以及通过施用化合物调节免疫应答的新方法。
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公开(公告)号：US08165823B2
公开(公告)日：2012-04-24
申请号：US11988895
申请日：2006-07-15
Applicant: Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
Inventor： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
Abstract: A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen.
Abstract translation: 用于鉴定作为宿主生物体中佐剂的多肽的方法。 本发明进一步提供了包含所述多肽并任选进一步包含抗原的佐剂组合物。
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公开(公告)号：US07994283B2
公开(公告)日：2011-08-09
申请号：US12455444
申请日：2009-06-01
Applicant: Nicholas Valiante
Inventor： Nicholas Valiante
IPC: C07K14/00
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/53 , C07K14/395 , C07K14/70521 , C07K19/00 , C07K2319/00 , C12N2770/24222
Abstract: A dimeric protein comprising a first fusion protein and a second fusion protein, wherein the first fusion protein comprises a targeting domain, a leucine zipper domain, and an antigen; and wherein the second fusion protein comprises a targeting domain, a leucine zipper domain, and optionally an antigen. Nucleic acid vectors encoding proteins of the invention are provided, particularly for use in nucleic acid vaccination.
Abstract translation: 包含第一融合蛋白和第二融合蛋白的二聚蛋白，其中所述第一融合蛋白包含靶向结构域，亮氨酸拉链结构域和抗原; 并且其中所述第二融合蛋白包含靶向结构域，亮氨酸拉链结构域和任选的抗原。 提供编码本发明蛋白质的核酸载体，特别是用于核酸疫苗接种。
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公开(公告)号：US07550145B2
公开(公告)日：2009-06-23
申请号：US10265083
申请日：2002-10-03
Applicant: Derek O'Hagan , Nicholas Valiante
Inventor： Derek O'Hagan , Nicholas Valiante
IPC: A61K39/29
CPC classification number: A61K39/39 , A61K39/095 , A61K39/21 , A61K39/29 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N7/00 , C12N2740/16034 , C12N2770/24234
Abstract: Adjuvant compositions comprising type 1 interferon inducers, such as double-stranded RNA, in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.
Abstract translation: 描述了包含1型干扰素诱导剂（例如双链RNA）与抗原递送系统和/或免疫刺激分子（例如免疫刺激性核酸序列）组合的辅助组合物，用于增强共同施用的抗原的免疫应答。
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