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11.发明公开公开(公告)号：US20230285460A1
公开(公告)日：2023-09-14
申请号：US18162380
申请日：2023-01-31
发明人： Heiko SCHUSTER , Franziska HOFFGAARD , Jens FRITSCHE , Oliver SCHOOR , Toni WEINSCHENK , Daniel Johannes KOWALEWSKI , Chih-Chiang TSOU
IPC分类号： A61K35/17 , A61K39/00 , A61K45/06 , C07K16/28 , C07K7/06 , C07K16/24 , C12N5/0783 , A61P35/02 , A61K39/39 , A61K39/395 , A61K38/08 , C07K14/54 , A61K39/12 , C07K14/47 , A61P35/00 , A61K45/00
CPC分类号： A61K35/17 , A61K39/001102 , A61K39/001118 , A61K39/001114 , A61K45/06 , C07K16/2818 , C07K7/06 , C07K16/244 , C12N5/0636 , A61P35/02 , A61K39/39 , A61K39/39558 , C07K16/2821 , A61K38/08 , C07K14/5434 , A61K39/12 , C07K14/4748 , A61P35/00 , A61K2039/55538 , A61K45/05 , A61K2039/55533 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61K2039/5154 , A61K2039/55561 , A61K2039/55516 , A61K2039/5156
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230227518A1
公开(公告)日：2023-07-20
申请号：US18161423
申请日：2023-01-30
发明人： Colette SONG , Franziska HOFFGAARD , Daniel Johannes KOWALEWSKI , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH
IPC分类号： C07K14/47 , A61K39/00 , C07K16/30 , C12N5/0783 , C07K14/725 , A61K45/06 , A61K35/17 , C12N15/115 , A61P35/02 , A61P35/00 , C07K14/74 , C07K16/28
CPC分类号： C07K14/4748 , A61K39/0011 , C07K16/3053 , C07K16/30 , C07K16/3015 , C07K16/3023 , C12N5/0636 , C07K14/7051 , C07K16/303 , A61K39/001193 , A61K45/06 , A61K35/17 , C07K16/3069 , C12N15/115 , C07K16/3046 , A61P35/02 , A61K39/001186 , C07K16/3038 , C07K16/3061 , A61P35/00 , C07K14/70539 , C07K16/2833 , C07K2319/00 , C12N2310/16
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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13.发明公开公开(公告)号：US20230227517A1
公开(公告)日：2023-07-20
申请号：US18158734
申请日：2023-01-24
发明人： Andrea MAHR , Toni WEINSCHENK , Helen HOERZER , Oliver SCHOOR , Jens FRITSCHE , Harpreet SINGH
IPC分类号： C07K14/47 , A61K35/17 , A61K39/00 , C07K7/06 , C07K7/08 , C07K14/705 , C07K14/74 , C07K14/82 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/32 , C12N5/0783 , C12N15/115 , C12P21/02 , C12Q1/6881 , C12Q1/6886 , G01N33/569 , G01N33/574
CPC分类号： C07K14/4748 , A61K35/17 , A61K39/0011 , C07K7/06 , C07K7/08 , C07K14/4705 , C07K14/4738 , C07K14/705 , C07K14/70539 , C07K14/82 , C07K16/18 , C07K16/28 , C07K16/2833 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K16/32 , C12N5/0636 , C12N15/115 , C12P21/02 , C12Q1/6881 , C12Q1/6886 , G01N33/56977 , G01N33/57449 , G01N33/57492 , A61K38/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230203114A1
公开(公告)日：2023-06-29
申请号：US18063430
申请日：2022-12-08
发明人： Oliver SCHOOR , Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Jens FRITSCHE , Harpreet SINGH
IPC分类号： C07K14/47 , A61P35/00 , A61K39/00 , C07K14/74 , C07K16/28 , C12N5/0783 , C12N15/113 , C07K14/725 , C07K16/30
CPC分类号： C07K14/4748 , A61P35/00 , A61K39/001154 , A61K39/0011 , C07K14/70539 , C07K16/2833 , C12N5/0636 , C12N15/1138 , C07K14/7051 , C07K16/3046 , C07K16/3076 , C07K2317/34 , C12N2501/50 , C12N2310/16 , A61K2039/5154 , A61K2039/5158
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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15.发明公开公开(公告)号：US20230192791A1
公开(公告)日：2023-06-22
申请号：US17934663
申请日：2022-09-23
发明人： Colette SONG , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH
IPC分类号： C07K14/47 , C07K16/28 , C12N15/115 , G01N33/574 , C07K14/54 , C07K7/06 , C12N5/0783 , C07K16/30 , A61K39/00 , C07K14/74 , A61P35/00 , C07K14/725 , C12N15/10 , A61K35/17
CPC分类号： C07K14/4748 , C07K16/2818 , C12N15/115 , G01N33/57492 , C07K14/5434 , C07K7/06 , C12N5/0638 , C07K16/30 , A61K39/0011 , C07K14/70539 , A61P35/00 , A61K39/001102 , C07K14/7051 , C12N15/1062 , A61K35/17 , A61K2039/572 , C07K2319/00 , A61K2039/5158 , C12N2501/50 , A61K38/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230190808A1
公开(公告)日：2023-06-22
申请号：US17938577
申请日：2022-10-06
发明人： Jens HUKELMANN , Heiko SCHUSTER , Jens FRITSCHE , Oliver SCHOOR , Frank SCHWOEBEL , Lena Katharina FREUDENMANN
IPC分类号： A61K35/17 , C07K14/725 , C12N5/0783 , C12N5/10
CPC分类号： A61K35/17 , C07K14/7051 , C12N5/0638 , C12N5/10
摘要： A method of treating a metastatic lesion that presents a peptide containing SLLQHLIGL (SEQ ID NO: 310) on a cell surface, including selecting a patient having a metastatic lesion and administering to the patient a composition containing recombinant T lymphocytes or activated T lymphocytes that express a T cell receptor, or a functional fragment thereof, that is reactive with, or binds to, an MHC ligand containing SLLQHLIGL (SEQ ID NO: 310).
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公开(公告)号：US20230088845A1
公开(公告)日：2023-03-23
申请号：US18056858
申请日：2022-11-18
发明人： Oliver SCHOOR , Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Jens FRITSCHE , Harpreet SINGH
IPC分类号： C07K14/47 , A61P35/00 , A61K39/00 , C07K14/74 , C07K16/28 , C12N5/0783 , C12N15/113 , C07K14/725 , C07K16/30
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230086855A1
公开(公告)日：2023-03-23
申请号：US18056887
申请日：2022-11-18
发明人： Oliver SCHOOR , Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Jens FRITSCHE , Harpreet SINGH
IPC分类号： C07K14/47 , A61P35/00 , A61K39/00 , C07K14/74 , C07K16/28 , C12N5/0783 , C12N15/113 , C07K14/725 , C07K16/30
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230043654A1
公开(公告)日：2023-02-09
申请号：US17933298
申请日：2022-09-19
发明人： Colette SONG , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH
IPC分类号： C07K14/47 , C07K7/06 , C07K14/725 , A61K35/17 , C07K14/74 , C07K16/30 , C07K16/28 , C12N15/10 , A61K39/00 , C07K14/54 , G01N33/574 , C12N5/0783 , C12N15/115 , A61P35/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230012265A1
公开(公告)日：2023-01-12
申请号：US17478041
申请日：2021-09-17
发明人： Colette SONG , Heiko SCHUSTER , Daniel Johannes KOWALEWSKI , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH
IPC分类号： C07K14/47 , A61K35/17 , A61K39/00 , C07K14/725 , C07K14/74 , C07K16/18 , C12N5/0783 , C12Q1/6886
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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