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    ABUSE-PROOFED ORAL DOSAGE FORM
    13.
    发明申请
    ABUSE-PROOFED ORAL DOSAGE FORM 审中-公开
    ABUS-PROOFED口服剂型

    公开(公告)号：US20140147499A1

    公开(公告)日：2014-05-29

    申请号：US14168159

    申请日：2014-01-30

    Applicant: GRÜNENTHAL GMBH

    Inventor： Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN ,  Elisabeth ARKENAU-MARIC

    IPC: A61K31/137 ,  A61K9/20

    CPC classification number: A61K31/137 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2095 ,  A61K9/2893 ,  A61K9/4808 ,  A61K31/135 ,  A61K47/10 ,  A61K47/38

    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.

    Abstract translation: 本发明涉及具有一次一次施用的（1R，2R）-3-（3-二甲基氨基-1-乙基-2-甲基 - 丙基）苯酚的受控释放的滥用防止口服剂型，其包含活性成分 至少一种合成或天然聚合物（C），延迟释放辅助物质，任选的生理上可接受的辅助物质（B）和任选的蜡（D），组分（A）和/或其一种或多种药学上可接受的盐 （C）或（D）在每种情况下表现出至少500N的断裂强度，优选至少为1000N。

    Crush resistant delayed-release dosage forms
    18.
    发明申请
    Crush resistant delayed-release dosage forms 审中-公开

    公开(公告)号：US20150290138A1

    公开(公告)日：2015-10-15

    申请号：US14749939

    申请日：2015-06-25

    Applicant: GRÜNENTHAL GMBH

    Inventor： Elisabeth ARKENAU-MARIC ,  Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN

    IPC: A61K9/20 ,  A61J3/10 ,  A61K31/485

    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.

    PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
    19.
    发明申请
    PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM 审中-公开
    生产滥用药物剂型的方法

    公开(公告)号：US20150283086A1

    公开(公告)日：2015-10-08

    申请号：US14745661

    申请日：2015-06-22

    Applicant: GRÜNENTHAL GMBH

    Inventor： Elisabeth ARKENAU-MARIC ,  Johannes BARTHOLOMÄUS

    IPC: A61K9/20 ,  A61K9/16 ,  A61K31/485

    CPC classification number: A61K9/2095 ,  A61K9/1694 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K31/05 ,  A61K31/135 ,  A61K31/485

    Abstract: The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.

    Abstract translation: 本发明涉及生产防滥用剂型的方法，除了具有潜在滥用潜力和任选的生理上可接受的辅助物质的一种或多种活性成分外，还含有至少一种具有断裂性的合成或天然聚合物（C） 至少500N的强度，其中所述制剂混合物与所述聚合物（C）的溶剂至少以使得所述制剂混合物至少均匀润湿的量组合，所述至少润湿的组合物任选分成亚部分， 干燥并成型以产生剂型。

    ABUSE-PROOFED ORAL DOSAGE FORM
    20.
    发明申请
    ABUSE-PROOFED ORAL DOSAGE FORM 审中-公开
    ABUS-PROOFED口服剂型

    公开(公告)号：US20150216821A1

    公开(公告)日：2015-08-06

    申请号：US14685718

    申请日：2015-04-14

    Applicant: GRÜNENTHAL GMBH

    Inventor： Johannes BARTHOLOMÄUS ,  Heinrich KUGELMANN ,  Elisabeth ARKENAU-MARIC

    IPC: A61K31/137 ,  A61K9/28 ,  A61K9/20

    CPC classification number: A61K31/137 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2095 ,  A61K9/2893 ,  A61K9/4808 ,  A61K31/135 ,  A61K47/10 ,  A61K47/38

    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.

    Abstract translation: 本发明涉及具有受控释放的（1R，2R）-3-（3-二甲基氨基-1-乙基-2-甲基 - 丙基）苯酚的滥用防治口服剂型，每天一次给药，其包含活性成分 至少一种合成或天然聚合物（C），延迟释放辅助物质，任选的生理上可接受的辅助物质（B）和任选的蜡（D），组分（A）和/或其一种或多种药学上可接受的盐 （C）或（D）在每种情况下表现出至少500N的断裂强度，优选至少为1000N。

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