公开(公告)号：US5351127A

公开(公告)日：1994-09-27

申请号：US900217

申请日：1992-06-17

申请人： David A. King ,  Jens-Peter Seher

发明人： David A. King ,  Jens-Peter Seher

IPC分类号： G01N21/27 ,  G01N21/55 ,  G01N21/63

CPC分类号： G01N21/553

摘要： A measuring instrument utilizing surface plasmon resonance is described. The instrument employs no moving mechanical part because it produces the resonance by changing the parameters either electrically or acoustically, and it detects the reflection by a stationary detector.

摘要翻译： 描述了利用表面等离子体共振的测量仪器。 仪器不使用移动的机械部件，因为它通过电或声学改变参数来产生谐振，并且它通过固定的检测器检测反射。

公开(公告)号：US5341215A

公开(公告)日：1994-08-23

申请号：US889629

申请日：1992-05-28

申请人： Jens-Peter Seher

发明人： Jens-Peter Seher

IPC分类号： G01N33/543 ,  G01N21/27 ,  G01N21/55 ,  G01N21/64 ,  G01N21/00 ,  C12M1/34

CPC分类号： G01N21/648 ,  G01N21/553 ,  Y10S435/808

摘要： A method and apparatus for detecting the presence and/or concentration of biomolecules, in particular DNA, by providing a boundary surface between an optically denser medium and an optically rarer medium. Biomolecules adsorb to the boundary surface and alter the characteristics of impinging light. The method and apparatus use surface plasmon resonance (SPR) to excite the biomolecules. The angle of incidence of the impinging light is maintained at the angle at which SPR occurs, thereby controlling the energy transferred to the biomolecules. The energy transferred to the biomolecules causes the biomolecules to generate excitation light which is reflected and monitored at the boundary surface. The angle of incidence is controlled by rotating a desk such that the intensity of the reflected light is always maintained at a minimum which ensures that the angle of incidence is equal to the angle at which SPR occurs.

摘要翻译： 一种用于通过在光密度较高的介质和光学稀少介质之间提供边界表面来检测生物分子，特别是DNA的存在和/或浓度的方法和装置。 生物分子吸附在边界表面，改变了入射光的特性。 该方法和装置使用表面等离子体共振（SPR）来激发生物分子。 入射角的入射角保持在SPR发生的角度，从而控制转移到生物分子的能量。 转移到生物分子的能量导致生物分子产生在边界表面反射和监测的激发光。 通过旋转桌子来控制入射角，使得反射光的强度总是保持在最小，这确保入射角等于发生SPR的角度。

公开(公告)号：US07604138B2

公开(公告)日：2009-10-20

申请号：US10567978

申请日：2004-08-03

申请人： Jens-Peter Seher ,  Christopher Sprague Boit

发明人： Jens-Peter Seher ,  Christopher Sprague Boit

IPC分类号： B65D39/00 ,  B65D41/00 ,  B65D43/00 ,  B65D47/00 ,  B65D51/00 ,  A61B69/00 ,  B01L11/00

CPC分类号： A61J1/1406 ,  B01L3/50825 ,  B01L2200/026 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/049 ,  B01L2400/0611 ,  Y10T137/9247

摘要： A closure device (10) for a container (12) includes a filling device (14) that can be attached to an opening (16) of the container (12) A closure structure such as a membrane (18), a system (34), or a duckbill closure (54, 84) is attached to the filling device (14) in such a way that the opening (16) of the container (12) is sealed when the filling device (14) is attached to the opening (16). The closure structure is coated at least partially with polytetrafluoroethylene (22, 38, 60, 94) on one side (20, 40, 58, 90) that is accessible from outside the container (12) in the assembled state of the filling device (14) on the container (12).

摘要翻译： 用于容器（12）的封闭装置（10）包括能够附接到容器（12）的开口（16）的填充装置（14）。封闭结构例如膜（18），系统（34） ）或鸭嘴闭合件（54,84）以这样的方式附接到填充装置（14），使得当填充装置（14）附接到开口（14）时，容器（12）的开口（16）被密封 （16）。 封闭结构至少部分地涂覆在一侧（20,40,58,90）上的聚四氟乙烯（22,38,60,94），所述聚四氟乙烯（22,38,60,94）在填充装置的组装状态下可从容器（12）的外部接近 14）在容器（12）上。

公开(公告)号：US20070023430A1

公开(公告)日：2007-02-01

申请号：US10567978

申请日：2004-08-03

申请人： Jens-Peter Seher ,  Christopher Boit

发明人： Jens-Peter Seher ,  Christopher Boit

IPC分类号： B65D51/00 ,  A61B19/00 ,  F16L35/00

CPC分类号： A61J1/1406 ,  B01L3/50825 ,  B01L2200/026 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/049 ,  B01L2400/0611 ,  Y10T137/9247

摘要： The invention relates to a closure device (10) for a container (12) comprising a filling device (14) that can be attached to an opening (16) of the container (12), and a closure means (18) that is attached to the filling device (14) in such a way that the opening (16) of the container (12) is sealed when the filling device (14) is attached to the opening (16) and that is coated at least partially with polytetrafluoroethylene (22) on one side (20) that is accessible from outside the container (12) in the assembled state of the filling device (14) on the container (12).

摘要翻译： 本发明涉及一种用于容器（12）的封闭装置（10），其包括能够附接到容器（12）的开口（16）的填充装置（14），以及附接的封闭装置（18） 以使得当所述填充装置（14）附接到所述开口（16）时所述容器（12）的开口（16）被密封并且至少部分地用聚四氟乙烯（ 在容器（12）上的填充装置（14）的组装状态下可从容器（12）的外部进入的一侧（20）上的一个侧面（22）。

公开(公告)号：US5538850A

公开(公告)日：1996-07-23

申请号：US228233

申请日：1994-04-15

申请人： David A. King ,  Jens-Peter Seher

发明人： David A. King ,  Jens-Peter Seher

IPC分类号： G01N21/64 ,  G01N21/27 ,  G01N21/55 ,  G01N33/542 ,  G01N33/552

CPC分类号： G01N21/648 ,  G01N21/552 ,  Y10S435/808 ,  Y10S436/805

摘要： The presence of trace materials in a sample is detected using both macroscopic and microscopic properties. A detector includes a light source and an optical resonator. The light source may be located either inside the resonance cavity of the resonator or outside the cavity, in which case it may be a semi-conductor such as a semi-conductor laser or a superluminescent diode. The detector also includes at least one reflective member that has a total internal reflection (TIR) surface and may be a passive device or an active gain element. Light from the light source is preferably focussed onto a single point of reflection on the TIR surface. The test sample is positioned within the evanescent field region of the TIR surface. Optical changes arising within the evanescent field region, such as excitation of fluorescence in the sample, changes in its refractive index, and changes in the resonant frequency of the optical resonator, are then detected. These changes are then sensed to determine the amount or at least presence of analyte located at the TIR surface.

摘要翻译： 使用宏观和微观性质检测样品中痕量物质的存在。 检测器包括光源和光谐振器。 光源可以位于谐振器的谐振腔内部或腔的外部，在这种情况下，它可以是诸如半导体激光器或超发光二极管的半导体。 检测器还包括具有全内反射（TIR）表面的至少一个反射构件，并且可以是无源器件或有源增益元件。 来自光源的光优选聚焦在TIR表面上的单个反射点上。 测试样品位于TIR表面的消逝场区域内。 然后检测在消逝场区域内产生的光学变化，例如样品中荧光的激发，其折射率的变化以及光谐振器的谐振频率的变化。 然后感测这些变化以确定位于TIR表面处的分析物的量或至少存在。

公开(公告)号：US5437840A

公开(公告)日：1995-08-01

申请号：US227932

申请日：1994-04-15

申请人： David A. King ,  Jens-Peter Seher

发明人： David A. King ,  Jens-Peter Seher

IPC分类号： G01N21/64 ,  G01N21/27 ,  G01N21/39 ,  G01N21/55 ,  G01N33/542 ,  G01N21/41

CPC分类号： G01N21/648 ,  G01N21/552 ,  G01N2021/391 ,  Y10S436/805

摘要： The presence of trace materials in a sample is detected using both macroscopic and microscopic properties. A detector includes a light source and an optical resonator. The light source may be located either inside the resonance cavity of the resonator or outside the cavity, in which case it may be a semi-conductor such as a semi-conductor laser or a superluminescent diode. The detector also includes at least one reflective member that has a total internal reflection (TIR) surface and may be a passive device or an active gain element. Light from the light source is preferably focussed onto a single point of reflection on the TIR surface. The test sample is positioned within the evanescent field region of the TIR surface. Optical changes arising within the evanescent field region, such as excitation of fluorescence in the sample, changes in its refractive index and changes in the resonant frequency of the optical resonator, are then detected. These changes are then sensed to determine the amount or at least presence of analyte located at the TIR surface.

摘要翻译： 使用宏观和微观性质检测样品中痕量物质的存在。 检测器包括光源和光谐振器。 光源可以位于谐振器的谐振腔内部或腔的外部，在这种情况下，它可以是诸如半导体激光器或超发光二极管的半导体。 检测器还包括具有全内反射（TIR）表面的至少一个反射构件，并且可以是无源器件或有源增益元件。 来自光源的光优选聚焦在TIR表面上的单个反射点上。 测试样品位于TIR表面的消逝场区域内。 然后检测在ev逝场区域内产生的光学变化，例如样品中荧光的激发，其折射率的变化和光学谐振器的谐振频率的变化。 然后感测这些变化以确定位于TIR表面处的分析物的量或至少存在。

公开(公告)号：US4953557A

公开(公告)日：1990-09-04

申请号：US345927

申请日：1989-05-01

申请人： Michael Frankenreiter ,  Rainer Rometsch ,  Jens-Peter Seher

发明人： Michael Frankenreiter ,  Rainer Rometsch ,  Jens-Peter Seher

IPC分类号： A61B5/0215 ,  A61B5/022

CPC分类号： A61B5/02156 ,  A61B5/022

摘要： A monitor for the automated non-invasive measurement of a patient's blood pressure comprising apparatus for automatically inflating and deflating a cuff which is to be applied around a patient's extremity, first and second pressure sensors coupled to the airway of said cuff, each providing an electronic signal indicative of cuff pressure, and a processor responding to the signals obtained by said pressure sensors for stopping the inflation of the cuff when a maximum cuff pressure is reached, and for calculating the blood pressure from the oscillations of the pressure signal. A memory is connected to said processor in which calibration values indicating the pressure related to the electronic signals provided by each of said two pressure sensors are stored. The processor is adapted to access and compare those calibration values which correspond to the actual values of said electronic signals provided by said two sensors to monitor supply and/or reference voltages, and to cause the deflation of the cuff when the actual calibration values differ from each other or the supply and/or reference voltages each differ from a related predetermined value more than a predetermined amount, thus preventing any pressure raise over predetermined limits in case of any malfunction of the monitor without the use of mechanical pressure switches.

公开(公告)号：US20080221033A1

公开(公告)日：2008-09-11

申请号：US11996810

申请日：2006-07-27

申请人： Jens-Peter Seher ,  Malcolm G. Pluskal

发明人： Jens-Peter Seher ,  Malcolm G. Pluskal

IPC分类号： G01N33/68 ,  A61K38/00 ,  A61P9/00 ,  A61B5/00

CPC分类号： G01N33/6887 ,  G01N33/74

摘要： In a cardiac monitoring method, at east an inactive natriuretic peptide (22) and an active natriuretic peptide (20) are assayed in a biological sample taken from a patient. Both the inactive and active natriuretic peptides are produced in the patient responsive to cardiac stress. A therapeutic agent (26), such as a synthetic or mimetic natriuretic peptide, is administered to the patient. The administered therapeutic agent substantially interferes with the active natriuretic peptide assay but does not substantially interfere with the inactive natriuretic peptide assay. Kinetics of the administered therapeutic agent are determined based on at least the active natriuretic peptide assay. Cardiac diagnostic information is determined based on at least the inactive natriuretic peptide assay.

摘要翻译： 在心脏监测方法中，在取自患者的生物样品中，在东侧测定不活动的利尿钠肽（22）和活性利尿钠肽（20）。 无活性和活性利尿钠肽都是在患有心脏应激的患者中产生的。 向患者施用治疗剂（26），例如合成或模拟的利尿钠肽。 施用的治疗剂基本上干扰活性利尿钠肽测定，但实质上不干扰无活性利钠肽测定。 基于至少活性利尿钠肽测定来测定施用的治疗剂的动力学。 至少基于无效利尿钠肽测定来确定心脏诊断信息。

公开(公告)号：US5514596A

公开(公告)日：1996-05-07

申请号：US419653

申请日：1995-04-10

申请人： David A. King ,  Jens-Peter Seher

发明人： David A. King ,  Jens-Peter Seher

IPC分类号： G01N21/64 ,  G01N21/27 ,  G01N21/39 ,  G01N21/55 ,  G01N33/542 ,  G01N21/41

CPC分类号： G01N21/648 ,  G01N21/552 ,  G01N2021/391 ,  Y10S436/805

摘要： The presence of trace materials in a sample is detected using both macroscopic and microscopic properties. A detector includes a light source and an optical resonator. The light source may be located either inside the resonance cavity of the resonator or outside the cavity, in which case it may be a semi-conductor such as a semi-conductor laser or a superluminescent diode. The detector also includes at least one reflective member that has a total internal reflection (TIR) surface and may be a passive device or an active gain element. Light from the light source is preferably focussed onto a single point of reflection on the TIR surface. The test sample is positioned within the evanescent field region of the TIR surface. Optical changes arising within the evanescent field region, such as excitation of fluorescence in the sample, changes in its refractive index, and changes in the resonant frequency of the optical resonator, are then detected. These changes are then sensed to determine the amount or at least presence of analyte located at the TIR surface.

摘要翻译： 使用宏观和微观性质检测样品中痕量物质的存在。 检测器包括光源和光谐振器。 光源可以位于谐振器的谐振腔内部或腔的外部，在这种情况下，它可以是诸如半导体激光器或超发光二极管的半导体。 检测器还包括具有全内反射（TIR）表面的至少一个反射构件，并且可以是无源器件或有源增益元件。 来自光源的光优选聚焦在TIR表面上的单个反射点上。 测试样品位于TIR表面的消逝场区域内。 然后检测在消逝场区域内产生的光学变化，例如样品中荧光的激发，其折射率的变化以及光谐振器的谐振频率的变化。 然后感测这些变化以确定位于TIR表面处的分析物的量或至少存在。

公开(公告)号：US4971063A

公开(公告)日：1990-11-20

申请号：US311322

申请日：1989-02-15

申请人： Erwin Flachslaender ,  Jens-Peter Seher

发明人： Erwin Flachslaender ,  Jens-Peter Seher

IPC分类号： A61B5/022 ,  A61B5/0225

CPC分类号： A61B5/02141 ,  A61B5/02233

摘要： A pneumatic connector for an automated non-invasive blood pressure monitor having a connector body (1) containing two oppositely arranged hollow cavities (8) for insertion of a differential pressure sensor in each cavity. The hollow cavities are connected by a bore (10) which is in connection with the main airway (6,7) in the connector body (1). Additionally, both differential pressure sensors have differential pressure sensors which are connected to the ambient air via a secondary airway.