-
公开(公告)号：US09953133B2
公开(公告)日：2018-04-24
申请号：US14730037
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf
CPC classification number: G06F19/26 , C12Q1/6841 , G01N21/6456 , G06F19/20 , C12Q2543/10 , C12Q2563/107
Abstract: Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of a plurality of biomarkers, which may be used to generate a multiplexed image of a tissue sample. Based on the identified regions, cells may be extracted and localized sequence data may be generated specific to the regions-of-interest.
-
公开(公告)号：US20140372450A1
公开(公告)日：2014-12-18
申请号：US13917695
申请日：2013-06-14
Applicant: General Electric Company
Inventor： John Frederick Graf , Brion Daryl Sarachan , Maria Ildiko Zavodszky , Lee Aaron Newberg , Chinnappa Dilip Kodira
CPC classification number: G16B20/00 , G06F16/2246 , G16B5/00
Abstract: The invention relates generally to a method for interactive viewing and analysis of high content data in a biological pathway context. The high content data maybe related to the expression of biomarkers within a tissue, cellular, or cellular compartment of individual cell such that the data may reveal patterns of expression to identify a biological process, a clinical diagnosis or prognosis.
Abstract translation: 本发明一般涉及用于生物学途径上下文中高含量数据的交互式观看和分析的方法。 高含量数据可能与单个细胞的组织，细胞或细胞区室内的生物标志物的表达有关，使得数据可以揭示表达模式以鉴定生物过程，临床诊断或预后。
-
公开(公告)号：US12257457B2
公开(公告)日：2025-03-25
申请号：US17864212
申请日：2022-07-13
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
-
公开(公告)号：US11883689B2
公开(公告)日：2024-01-30
申请号：US17722948
申请日：2022-04-18
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Lakshmi Sireesha Kaanumalle , Victoria Eugenia Cotero , John Frederick Graf
CPC classification number: A61N7/00 , A61N1/36189 , G01N33/68 , A61N2007/0004
Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
-
公开(公告)号：US20200346043A1
公开(公告)日：2020-11-05
申请号：US16399692
申请日：2019-04-30
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
-
Patent Agency Ranking
公开(公告)号：US09613254B1
公开(公告)日：2017-04-04
申请号：US14871667
申请日：2015-09-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Vidya Pundalik Kamath
CPC classification number: G06K9/00147 , G06K9/00134 , G06K9/0014 , G06K9/3241 , G06K9/6215 , G06K9/6219 , G06K9/6224 , G06K9/6247
Abstract: The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a heterogeneity of the characterized cells.
-
公开(公告)号：US20160357906A1
公开(公告)日：2016-12-08
申请号：US14730037
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf
CPC classification number: G06F19/26 , C12Q1/6841 , G01N21/6456 , G06F19/20 , C12Q2543/10 , C12Q2563/107
Abstract: Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of a plurality of biomarkers, which may be used to generate a multiplexed image of a tissue sample. Based on the identified regions, cells may be extracted and localized sequence data may be generated specific to the regions-of-interest.
Abstract translation: 公开了细胞图中感兴趣区域的识别。 在某些实施方案中，感兴趣区域的鉴定基于多个生物标志物的使用，其可用于产生组织样本的多路复用图像。 基于所识别的区域，可以提取单元，并且可以生成特定于感兴趣区域的局部序列数据。
-
公开(公告)号：US11786760B2
公开(公告)日：2023-10-17
申请号：US16709717
申请日：2019-12-10
Applicant: General Electric Company
Inventor： John Frederick Graf , Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , David Andrew Shoudy
IPC: A61N7/00
CPC classification number: A61N7/00 , A61N2007/0026 , A61N2007/0052 , A61N2007/0086
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
-
公开(公告)号：US20220362587A1
公开(公告)日：2022-11-17
申请号：US17864212
申请日：2022-07-13
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
-
公开(公告)号：US20220233888A1
公开(公告)日：2022-07-28
申请号：US17722948
申请日：2022-04-18
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Lakshmi Sireesha Kaanumalle , Victoria Eugenia Cotero , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
-
-
-
-
-
-
-
-
-
Search Results
24
records
(took 0.017 seconds)
