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公开(公告)号：US09797767B2
公开(公告)日：2017-10-24
申请号：US14469362
申请日：2014-08-26
Applicant: GENERAL ELECTRIC COMPANY
CPC classification number: G01J1/0228 , G01N21/274 , G01N21/64 , G01N21/6458 , G02B21/365
Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.
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公开(公告)号：US10746980B2
公开(公告)日：2020-08-18
申请号：US14934412
申请日：2015-11-06
Applicant: GENERAL ELECTRIC COMPANY
Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that includes a variety of calibration features. The calibration features comprise a geometric calibration, an illumination calibration, and an optical calibration. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.
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公开(公告)号：US10317663B2
公开(公告)日：2019-06-11
申请号：US14634465
申请日：2015-02-27
Applicant: General Electric Company
Inventor： Alex David Corwin
Abstract: The present approach relates to the measure of the planar tilt of a slide on a microscope using an integrated auto-focuser. The tilt of the slide can be used to detect improperly loaded slides (i.e. if the slide is resting on either the cover-slip or a printed barcode), compensate for misalignment between the microscope optical axis and the slide, and reduce subsequent focusing times.
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公开(公告)号：US20160252713A1
公开(公告)日：2016-09-01
申请号：US14634465
申请日：2015-02-27
Applicant: General Electric Company
Inventor： Alex David Corwin
CPC classification number: G02B21/365 , G02B7/38 , G02B21/244
Abstract: The present approach relates to the measure of the planar tilt of a slide on a microscope using an integrated auto-focuser. The tilt of the slide can be used to detect improperly loaded slides (i.e. if the slide is resting on either the cover-slip or a printed barcode), compensate for misalignment between the microscope optical axis and the slide, and reduce subsequent focusing times.
Abstract translation: 本方法涉及使用集成自动对焦器在显微镜上测量滑块的平面倾斜度。 幻灯片的倾斜可以用于检测不正确加载的幻灯片（即，如果幻灯片搁置在覆盖滑块或打印的条形码上），则补偿显微镜光轴和幻灯片之间的未对准，并减少随后的聚焦时间。
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公开(公告)号：US20160170197A1
公开(公告)日：2016-06-16
申请号：US14934412
申请日：2015-11-06
Applicant: GENERAL ELECTRIC COMPANY
Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that includes a variety of calibration features. The calibration features comprise a geometric calibration, an illumination calibration, and an optical calibration. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.
Abstract translation: 公开了用于校准诸如显微镜的多个成像装置的方法。 在某些实施方案中，采用包括各种校准特征的校准板。 校准特征包括几何校准，照明校准和光学校准。 根据本方法校准的成像装置可用于生成具有一致属性（例如亮度）的图像，而不管采用何种成像装置。
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Patent Agency Ranking
公开(公告)号：US20150198580A1
公开(公告)日：2015-07-16
申请号：US14153315
申请日：2014-01-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brian James Grimmond , Brian Christopher Bales , Alex David Corwin , Adriana Ines Larriera Moreno , Christine Lynne Pitner
IPC: G01N33/483
CPC classification number: G01N33/4833 , B01L3/508 , B01L2300/041 , B01L2300/0822 , G01N2035/00138 , G02B21/34
Abstract: The invention provides a coverslip for automated decoverslipping of a tissue bearing slide comprising a horizontal base portion having a length, width, and height, at least two side wall portions extending downward from opposite sides of the base portion each having a length and width and h; and wherein the total wall volume to base volume ratio is greater than or equal to approximately 0.025.
Abstract translation: 本发明提供一种盖玻片，用于组织支承滑动件的自动倒瓶，其包括具有长度，宽度和高度的水平基部，至少两个侧壁部分，其从基部的相对侧向下延伸，每个侧壁具有长度和宽度，并且h ; 并且其中总壁体积与基体积体积比大于或等于大约0.025。
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公开(公告)号：US11597960B2
公开(公告)日：2023-03-07
申请号：US16459336
申请日：2019-07-01
Applicant: General Electric Company
Inventor： Alex David Corwin , Erik Leeming Kvam , Christine Lynne Surrette , Brian Joseph Scherer , Pei-Hsin Kuo , Ralf Lenigk
IPC: C12Q1/14 , C12Q1/04 , C12M3/06 , C12Q1/06 , C12M1/32 , C12M1/34 , C12M1/00 , C12M1/04 , G01N21/01 , G06T7/00
Abstract: The present disclosure relates to approaches for assessing a sample or the presence of microorganisms. The sample, in certain implementations may be assessed for one or both of absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). sample partition device may be employed that partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.
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公开(公告)号：US20210001336A1
公开(公告)日：2021-01-07
申请号：US16459363
申请日：2019-07-01
Applicant: General Electric Company
Inventor： Alex David Corwin , Erik Leeming Kvam , Christine Lynne Surrette , Brian Joseph Scherer , Pei-Hsin Kuo , Ralf Lenigk , Tyler John Hammond
Abstract: The present disclosure relates to a consumable sample partition device and it assembly and use. The sample partition device can be used to test a sample for absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). The sample partition device partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.
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公开(公告)号：US10088658B2
公开(公告)日：2018-10-02
申请号：US13846490
申请日：2013-03-18
Applicant: General Electric Company
Inventor： Kevin Bernard Kenny , Alex David Corwin
Abstract: Referencing of image acquired in multiple rounds of imaging is disclosed. In certain implementations, a baseline round of images are acquired and registered to one another to establish a global transformation matrix. In a subsequent round of image acquisition, a limited number of field of view images are initially acquired and registered to the corresponding baseline images to solve for translation, rotation, and scale. The full set of baseline images is then acquired for the subsequent round and each image is pre-rotated and pre-scaled based on the transform determined for the subset of images. The pre-rotated, pre-scaled images are then registered using a translation-only transform.
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公开(公告)号：US20150185453A1
公开(公告)日：2015-07-02
申请号：US14410890
申请日：2013-06-26
Applicant: General Electric Company
Inventor： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
CPC classification number: G02B21/008 , G01N1/30 , G01N1/312 , G01N35/00029 , G01N35/0092 , G01N35/0099
Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
Abstract translation: 一种用于处理和成像第一和第二多个样品的方法，包括处理来自所述第一多个样品的至少一个样品，对来自所述第一多个样品的所述至少一个样品进行成像，同时能够同时处理至少一个样品 从第二多个样本; 以及对来自所述第二多个样本的所述至少一个处理的样品进行成像。
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