公开(公告)号：US12281165B2

公开(公告)日：2025-04-22

申请号：US17677283

申请日：2022-02-22

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  A61K31/404 ,  A61K31/5517 ,  A61K31/706 ,  A61K38/05 ,  A61K47/68 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US12134649B2

公开(公告)日：2024-11-05

申请号：US17547528

申请日：2021-12-10

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  A61K38/08 ,  A61K39/395 ,  A61K47/65 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K16/30 ,  G01N33/569 ,  A61K39/00

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10556951B2

公开(公告)日：2020-02-11

申请号：US15918842

申请日：2018-03-12

Applicant: GENENTECH, INC.

Inventor： Shang-Fan Yu ,  Wei-Ching Liang ,  Yan Wu ,  Steven Leong ,  Andrew Polson

IPC: A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K47/68 ,  A61K39/00

Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10421822B2

公开(公告)日：2019-09-24

申请号：US16168503

申请日：2018-10-23

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: C07K16/40 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US10266597B2

公开(公告)日：2019-04-23

申请号：US15657472

申请日：2017-07-24

Applicant: Genentech, Inc.

Inventor： Bing Zheng ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: A61K39/395 ,  C07K16/28 ,  A61K31/5517 ,  A61K31/706 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574 ,  A61K47/68

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20190016826A1

公开(公告)日：2019-01-17

申请号：US16143098

申请日：2018-09-26

Applicant: Genentech, Inc.

Inventor： Yan Wu ,  Menno van Lookeren Campagne ,  Daniel Kirchhofer ,  Michael Terry Lipari ,  Kenneth J. Katschke, JR. ,  Paul M. Moran ,  Scott Stawicki ,  Wei-Ching Liang

IPC: C07K16/40

Abstract: The invention provides anti-HtrA1 antibodies and methods of using the same.

公开(公告)号：US10017572B2

公开(公告)日：2018-07-10

申请号：US15274603

申请日：2016-09-23

Applicant: Genentech, Inc.

Inventor： Jane L. Grogan ,  Robert J. Johnston ,  Yan Wu ,  Wei-Ching Liang ,  Patrick Lupardus ,  Mahesh Yadav ,  Dhaya Seshasayee ,  Meredith Hazen

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K45/06 ,  A61K38/17 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US09951133B2

公开(公告)日：2018-04-24

申请号：US15171128

申请日：2016-06-02

Applicant: GENENTECH, INC.

Inventor： Shang-Fan Yu ,  Wei-Ching Liang ,  Yan Wu ,  Steven Leong ,  Andrew Polson

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/48 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2333/70596 ,  G01N2458/00

Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US09738727B2

公开(公告)日：2017-08-22

申请号：US13651289

申请日：2012-10-12

Applicant: Genentech, Inc.

Inventor： Yan Wu ,  Menno van Lookeren-Campagne ,  Daniel Kirchhofer ,  Michael Terry Lipari ,  Kenneth J. Katschke, Jr. ,  Paul M. Moran ,  Scott Stawicki ,  Wei-Ching Liang

IPC: C07K16/40

CPC classification number: C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides anti-HtrA1 antibodies and methods of using the same.

公开(公告)号：US08975381B2

公开(公告)日：2015-03-10

申请号：US13929338

申请日：2013-06-27

Applicant: Genentech, Inc.

Inventor： Germaine Fuh ,  Hans-Peter Gerber ,  Wei-Ching Liang ,  Frederic Fellouse ,  Sachdev S. Sidhu ,  Christian Wiesmann

IPC: C07K16/22 ,  C07K16/00 ,  C07K16/32 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K2039/505 ,  A61K2039/55 ,  A61K2039/552 ,  C07K16/005 ,  C07K16/32 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6845

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract translation: 公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究，诊断和治疗应用中的用途。