公开(公告)号：US20210093655A1

公开(公告)日：2021-04-01

申请号：US17122946

申请日：2020-12-15

申请人： Emory University ,  The United States Government as represented by the Department of Veterans Affairs

发明人： Khalid Salaita ,  Cherry Wongtrakool ,  Kornelia Galior

IPC分类号： A61K31/713 ,  A61K31/712 ,  C07H21/04 ,  A61K45/06 ,  B82Y5/00 ,  A61K9/00 ,  A61K9/51 ,  A61P11/06 ,  A61K9/14

摘要： This disclosure relates to nucleobase polymers useful for degrading GATA-3 mRNA. In certain embodiments, this disclosure relates to nucleobase polymers and nanoparticles conjugated to nucleobase polymers disclosed herein. In certain embodiments, the nucleobase polymers or nanoparticles can be used in methods of managing disorders associated with excessive GATA-3 expression in inflammatory disorders and respiratory disorders such as asthma.

公开(公告)号：US10905710B2

公开(公告)日：2021-02-02

申请号：US16304549

申请日：2017-05-24

申请人： Emory University ,  The United States Government as represented by the Department of Veterans Affairs

发明人： Khalid Salaita ,  Cherry Wongtrakool ,  Kornelia Galior

IPC分类号： A61K31/713 ,  A61K31/712 ,  C07H21/04 ,  A61K9/00 ,  A61K9/51 ,  A61P11/06 ,  A61K9/14 ,  A61K45/06 ,  B82Y5/00

摘要： This disclosure relates to nucleobase polymers useful for degrading GATA-3 mRNA. In certain embodiments, this disclosure relates to nucleobase polymers and nanoparticles conjugated to nucleobase polymers disclosed herein. In certain embodiments, the nucleobase polymers or nanoparticles can be used in methods of managing disorders associated with excessive GATA-3 expression in inflammatory disorders and respiratory disorders such as asthma.

公开(公告)号：US20170114400A1

公开(公告)日：2017-04-27

申请号：US15332007

申请日：2016-10-24

申请人： Emory University

发明人： Khalid Salaita ,  Kevin Yehl

IPC分类号： C12Q1/68 ,  C12N9/22

CPC分类号： C12Q1/6827 ,  C12N9/22 ,  C12Q1/6825 ,  C12Y301/26004 ,  C12Q2521/327 ,  C12Q2525/121 ,  C12Q2563/149 ,  C12Q2565/107 ,  C12Q2565/131

摘要： This disclosure relates DNA based movement of objects. In certain embodiments, particles, pairs of particles, or a rods are conjugated with single stranded DNA that hybridizes to a single stranded RNA that is conjugated to a substrate. When the DNA particle, pair of particles, or rod interacts with the surface RNA in the presence of an endonuclease, such as RNase H and the DNA hybridizes to the RNA, then the particle, pair of particle, or rod moves along the surface. The complementarity of the DNA and RNA affect the velocity.