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公开(公告)号：US09951358B2
公开(公告)日：2018-04-24
申请号：US15111901
申请日：2015-01-16
申请人： Conagen Inc.
发明人： Hui Chen , Hongxue Wang , Oliver Yu
CPC分类号： C12P13/02 , A61K31/165 , C12N9/1029 , C12N9/1096 , C12N9/20 , C12N9/93 , C12N15/52 , C12Y602/01001
摘要： A biosynthetic method of making a capsaicinoid including expressing a first gene product of CS/AT3/Pun1 in a cellular system, growing the cellular system in a medium, and collecting the capsaicinoid. The biosynthetic method further includes expressing a second gene product of ACS1 and expressing a third gene product of pAMT in the cellular system.
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公开(公告)号：US09765104B2
公开(公告)日：2017-09-19
申请号：US15016725
申请日：2016-02-05
申请人： Conagen, Inc.
IPC分类号： C12P19/18 , C07H15/24 , C07H15/256 , C12N9/10 , C12P19/56
CPC分类号： C07H15/24 , C07H15/256 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/1051 , C12N9/1062 , C12P19/56 , C12Y204/01013 , C12Y204/01017
摘要： Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D3, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
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公开(公告)号：US20160208225A1
公开(公告)日：2016-07-21
申请号：US15016750
申请日：2016-02-05
申请人： Conagen, Inc.
IPC分类号： C12N9/10
CPC分类号： C07H15/24 , C07H15/256 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/1051 , C12N9/1062 , C12P19/56 , C12Y204/01013 , C12Y204/01017
摘要： Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D2, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
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公开(公告)号：US20240076702A1
公开(公告)日：2024-03-07
申请号：US18062628
申请日：2022-12-07
申请人： Conagen Inc.
摘要： Provided herein are methods for making gamma lactones comprising reacting a carboxylic acid substrate with a heterologous cytochrome P450 (CYP450) protein with carboxylic acid 4-hydroxylase activity.
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公开(公告)号：US20220325290A1
公开(公告)日：2022-10-13
申请号：US17720418
申请日：2022-04-14
申请人： Conagen Inc.
发明人： Rui Zhou , Junying Ma , Oliver Yu
摘要： The present invention relates to methods and transformed host cells for the production of eriodictyol from naringenin via bioconversion.
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公开(公告)号：US20210115454A1
公开(公告)日：2021-04-22
申请号：US17124336
申请日：2020-12-16
申请人： Conagen Inc. , Arch Innotek, LLC
发明人： Yechun Wang , Oliver Yu
IPC分类号： C12N15/52 , C12P23/00 , C12N9/90 , C12N9/02 , C12P5/02 , C12P7/26 , C12N9/10 , C12N15/70 , C12N15/81
摘要： The present invention relates to compositions and methods of producing carotenoids and carotenoid derivatives.
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公开(公告)号：US20200291441A1
公开(公告)日：2020-09-17
申请号：US16725242
申请日：2019-12-23
申请人： Conagen Inc.
发明人： Guohong Mao , Jacob Edward Vick , Michael Batten , Oliver Yu
IPC分类号： C12P19/56
摘要： The present disclosure relates to the use of beta-glucosidase to enhance the production efficiency of desired steviol glycosides, such as rebaudioside M (reb M).
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公开(公告)号：US10138263B2
公开(公告)日：2018-11-27
申请号：US15016750
申请日：2016-02-05
申请人： Conagen Inc.
IPC分类号： C07H15/24 , C07H15/256 , C12N9/10 , C12P19/56
摘要： Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D2, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
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19.发明申请METHODS OF USING CAPSAICIN SYNTHASE FOR THE MICROBIAL PRODUCTION OF CAPSAICINOIDS 有权使用CAPSAICIN SYNTHASE用于微粒生产CAPSAICINOIDS的方法公开(公告)号：US20160340701A1
公开(公告)日：2016-11-24
申请号：US15111901
申请日：2015-01-16
申请人： CONAGEN INC.
发明人： Hui Chen , Hongxue Wang , Oliver Yu
CPC分类号： C12P13/02 , A61K31/165 , C12N9/1029 , C12N9/1096 , C12N9/20 , C12N9/93 , C12N15/52 , C12Y602/01001
摘要： A biosynthetic method of making a capsaicinoid including expressing a first gene product of CS/AT3/Pun1 in a cellular system, growing the cellular system in a medium, and collecting the capsaicinoid. The biosynthetic method further includes expressing a second gene product of ACS1 and expressing a third gene product of pAMT in the cellular system.
摘要翻译： 制备辣椒素的生物合成方法，包括在细胞系统中表达CS / AT3 / Pun1的第一基因产物，在培养基中生长细胞系统，并收集辣椒素。 生物合成方法还包括在细胞系统中表达ACS1的第二基因产物并表达pAMT的第三基因产物。
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公开(公告)号：US20160207954A1
公开(公告)日：2016-07-21
申请号：US15016589
申请日：2016-02-05
申请人： Conagen, Inc.
IPC分类号： C07H15/24
CPC分类号： C07H15/24 , C07H15/256 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/1051 , C12N9/1062 , C12P19/56 , C12Y204/01013 , C12Y204/01017
摘要： Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five β-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D2, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
摘要翻译： 披露了一种称为新蛇菊苷D2的甜菊糖苷。 雷鲍迪苷D2具有连接到糖苷配基甜菊醇的五个β-葡糖基单元。 还公开了用于制备新蛇菊苷D2，UDP-糖基转移酶融合酶的方法和用于生产新蛇菊苷D和莱鲍迪甙E的方法。
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