公开(公告)号：US11699220B2

公开(公告)日：2023-07-11

申请号：US17061686

申请日：2020-10-02

Applicant: CHEMIMAGE CORPORATION

Inventor： Heather Gomer ,  Patrick Treado ,  Jihang Wang

IPC: G06T5/50 ,  H04N5/265 ,  G06T5/00 ,  G01N33/483 ,  H04N23/56 ,  H04N23/80 ,  H04N23/90 ,  A61B5/00

CPC classification number: G06T5/50 ,  G01N33/4833 ,  G06T5/007 ,  H04N5/265 ,  H04N23/56 ,  H04N23/80 ,  H04N23/90 ,  A61B5/0084 ,  G06T2207/10024 ,  G06T2207/10048 ,  G06T2207/20221 ,  G06T2207/30004

Abstract: Methods, systems, and computer program products of fusing Molecular Chemical Imaging (MCI) and Red Green Blue (RGB) images are disclosed herein. A sample is illuminated with illuminating photons which interact with the sample and are used to form MCI and RGB images. The MCI and RGB images are fused by way of mathematical operations to generate a RGB image with a detection overlay.

公开(公告)号：US20130342683A1

公开(公告)日：2013-12-26

申请号：US13973769

申请日：2013-08-22

Applicant: ChemImage Corporation

Inventor： Matthew Nelson ,  Jeffrey Cohen ,  Oksana Klueve ,  Patrick Treado ,  Charles Gardner

IPC: G01W1/00

CPC classification number: G01W1/00 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/1213 ,  G01N21/359

Abstract: A system and method for detecting environmental conditions using SWIR hyperspectral imaging. A method may comprise collecting a plurality of interacted photons from at least one location and passing the interacted photons through a tunable filter, filtering the interacted photons into a plurality of wavelength bands. These filtered photons may be detected and analyzed to determine the presence or absence of an environmental condition. A system may comprise at least one collection lens configured to collect at least one plurality of interacted photons from at least one location and a tunable filter for filtering the interacted photons into a plurality of wavelength bands. The system may further comprise a detector configured to detect the filtered photons and generate at least one hyperspectral image representative of the location. The system may further comprise a processor for analyzing the hyperspectral data set and determining the presence or absence of an environmental condition.

Abstract translation: 使用SWIR高光谱成像检测环境条件的系统和方法。 一种方法可以包括从至少一个位置收集多个相互作用的光子，并将相互作用的光子传递通过可调谐滤波器，将相互作用的光子过滤成多个波长带。 可以检测和分析这些过滤的光子以确定环境条件的存在或不存在。 系统可以包括配置成从至少一个位置收集至少一个多个相互作用的光子的至少一个集合透镜和用于将相互作用的光子滤波成多个波长带的可调滤波器。 该系统还可以包括检测器，其被配置为检测滤波的光子并且生成代表该位置的至少一个高光谱图像。 该系统还可以包括用于分析高光谱数据集并确定环境条件的存在或不存在的处理器。

公开(公告)号：US11234584B2

公开(公告)日：2022-02-01

申请号：US15374769

申请日：2016-12-09

Applicant: ChemImage Corporation

Inventor： Patrick Treado ,  Shona Stewart ,  Matthew P. Nelson

IPC: A61B1/07 ,  A61B1/06 ,  A61B5/00 ,  A61B1/04 ,  A61B1/00

Abstract: Medical imaging systems for use in conjunction with an endoscope are described. Generally, the medical imaging system includes an illumination source configured to generate illuminating photons. The illuminating photons are transmitted to one or more filters configured to filter a first plurality of illuminating photons and generate a first plurality of filtered photons comprising a first passband wavelength and a second plurality of filtered photons comprising a second passband wavelength. A sample is then illuminated with the first plurality of filtered photons and the second plurality of filtered photons to generate a first plurality of interacted photons and a second plurality of interacted photons. One or more detectors are configured to detect the first plurality of interacted photons and the second plurality of interacted photons and generate one or more image data sets.

公开(公告)号：US11145411B2

公开(公告)日：2021-10-12

申请号：US14440987

申请日：2013-11-06

Applicant: CHEMIMAGE CORPORATION ,  Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

Inventor： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

IPC: G01N21/65 ,  G01N33/49 ,  G16H50/20 ,  G16B40/00 ,  G01N33/574 ,  G01J3/44 ,  G01J3/18

Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

公开(公告)号：US10317282B2

公开(公告)日：2019-06-11

申请号：US15401716

申请日：2017-01-09

Applicant: CHEMIMAGE CORPORATION

Inventor： Matthew Nelson ,  Patrick Treado ,  Charles Gardner ,  Andrew Basta

IPC: G01J3/28 ,  H01L27/146 ,  G01N21/31 ,  G01N21/359 ,  A61B5/00 ,  G01J3/02 ,  G01J3/12

Abstract: The present disclosure provides systems and methods for determining the presence of a target material in a sample. In general terms, the system and method disclosed herein provide collecting interacted photons from a sample having a target material. The interacted photons are passed through a tunable filter to a VIS-NIR detector where the VIS-NIR detector generates a VIS-NIR hyperspectral image representative of the filtered interacted photons. The hyperspectral image of the filtered interacted photons is analyzed by comparing the hyperspectral image of the filtered interacted photons to known hyperspectral images to identify the presence of a target material in a sample. The systems and methods disclosed herein provide easy identification of the presence of a target material in a sample.

公开(公告)号：US09274046B2

公开(公告)日：2016-03-01

申请号：US13998776

申请日：2013-12-03

Applicant: ChemImage Corporation

Inventor： Shona Stewart ,  Patrick Treado ,  Heather Kirschner ,  Alan Wilson ,  Ryan Priore ,  Jeffrey Cohen ,  Serena Augustine

IPC: G01J3/28 ,  G01N21/25 ,  G01J3/02 ,  G01J3/32 ,  G01J3/44 ,  G01N21/31 ,  G01N21/35 ,  G02B21/00 ,  G02B21/16 ,  G02B21/36 ,  G01N21/21 ,  G01N21/33 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample.

Abstract translation: 一种使用高光谱成像分析器官样品的方法，包括照亮器官样品以产生相互作用的光子，收集相互作用的光子并使相互作用的光子通过可调滤光器。 检测过滤的相互作用的光子以产生高光谱图像。 生成亮场图像并与高光谱图像相关联。 提取并分析来自感兴趣位置的光谱，以评估器官样品的特征。 系统可以包括用于照亮器官样本并产生相互作用的光子的照明源，用于收集相互作用的光子的收集光学器件和用于过滤相互作用的光子的可调滤波器。 检测器被配置为检测滤波的光子并产生至少一个高光谱图像。 检测器还可以被配置为产生代表器官样本的至少一个亮场图像。

公开(公告)号：US20140042322A1

公开(公告)日：2014-02-13

申请号：US14055554

申请日：2013-10-16

Applicant: ChemImage Corporation

Inventor： Patrick Treado ,  MATTHEW NELSON ,  CHARLES GARDNER, JR.

IPC: G01N21/25

CPC classification number: G01N21/25 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/31 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/3155 ,  G01N2021/6423 ,  G01N2201/0221 ,  G01N2201/129

Abstract: A portable system and method for detecting drug materials. A portable system may comprise at least one collection lens for collecting a plurality of interacted photons, a tunable filter for filtering the photons, and a SWIR detector for generating at least one SWIR data set representative of a first location comprising an unknown sample. A processor may analyze the SWIR data set to associate the unknown material with a known drug material. A method may comprise collecting a plurality of interacted photons, filtering the interacted photons into a plurality of wavelength bands, detecting the filtered photons to generate a SWIR data set and analyzing the SWIR data set to associate an unknown material with a known drug material.

Abstract translation: 一种用于检测药物材料的便携式系统和方法。 便携式系统可以包括用于收集多个相互作用的光子的至少一个收集透镜，用于滤波光子的可调滤波器，以及用于生成代表包含未知样本的第一位置的至少一个SWIR数据集的SWIR检测器。 处理器可以分析SWIR数据集以将未知材料与已知药物材料相关联。 方法可以包括收集多个相互作用的光子，将相互作用的光子过滤成多个波长带，检测滤波后的光子以产生SWIR数据集，并分析SWIR数据集以将未知材料与已知药物材料相关联。