公开(公告)号：US10173991B2

公开(公告)日：2019-01-08

申请号：US15108584

申请日：2015-01-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  Zulan Pi ,  Jennifer X. Qiao ,  Soong-Hoon Kim ,  Tammy C. Wang ,  Ji Jiang ,  Heather Finlay ,  John Lloyd

IPC: C07D417/04 ,  C07D277/64 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used medicaments.

公开(公告)号：US20190002441A1

公开(公告)日：2019-01-03

申请号：US16122975

申请日：2018-09-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC: C07D403/06 ,  C07D403/02 ,  C07D417/14 ,  A61K31/505 ,  C07D239/557 ,  C07D401/14 ,  C07D401/06 ,  C07D471/04 ,  C07D239/54 ,  C07D239/545 ,  C07D403/14

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US10106528B2

公开(公告)日：2018-10-23

申请号：US15468230

申请日：2017-03-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC: C07D403/06 ,  A61K31/505 ,  C07D239/54 ,  C07D239/545 ,  C07D401/14 ,  C07D403/02 ,  C07D417/14 ,  C07D471/04 ,  C07D401/06 ,  C07D403/14 ,  C07D239/557

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US09493412B2

公开(公告)日：2016-11-15

申请号：US14346751

申请日：2012-09-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jennifer X. Qiao ,  Heather Finlay ,  Ji Jiang ,  John Lloyd ,  Carol Hui Hu ,  Zulan Pi ,  George O. Tora ,  James Neels ,  Jon J. Hangeland ,  Todd J. Friends

IPC: C07D207/38 ,  C07D409/12 ,  C07D471/04 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D403/12 ,  C07D401/04 ,  C07D405/12 ,  C07F7/08

CPC classification number: C07D207/38 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07F7/0812

Abstract: The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

公开(公告)号：US20150239879A1

公开(公告)日：2015-08-27

申请号：US14427105

申请日：2013-09-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： George O. Tora ,  Heather Finlay ,  Carol Hui Hu ,  Ji Jiang ,  James A. Johnson ,  Soong-Hoon Kim ,  John Lloyd ,  Brandon Parkhurst ,  Zulan Pi ,  Jennifer X. Qiao ,  Tammy C. Wang

IPC: C07D417/06 ,  C07D417/14

CPC classification number: C07D417/06 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US20140235608A1

公开(公告)日：2014-08-21

申请号：US14347683

申请日：2012-09-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： John Lloyd ,  Jeniffer X. Qiao ,  Heather Finlay ,  James Neels ,  Zulan Pi ,  Carol Hui Hu ,  Tammy C. Wang

IPC: C07D417/12 ,  C07D401/12 ,  C07D413/12 ,  C07D213/81

CPC classification number: C07D213/81 ,  C07D213/79 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US20140213588A1

公开(公告)日：2014-07-31

申请号：US14346747

申请日：2012-09-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Lynn Abell ,  Leonard Adam ,  Cullen L. Cavallaro ,  Heather Finlay ,  Todd J. Friends ,  Jon J. Hangeland ,  Ji Jiang ,  R. Michael Lawrence ,  Jennifer X. Qiao ,  Carol Hui Hu ,  Tammy C. Wang

IPC: C07D417/06 ,  C07D417/04 ,  C07D409/04 ,  C07D413/06 ,  C07D405/06 ,  C07D233/61 ,  C07D401/06 ,  C07D207/277 ,  C07D405/04

CPC classification number: C07D207/277 ,  C07D207/28 ,  C07D207/38 ,  C07D233/61 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. The disclosure also provides a novel method of treating diseases or conditions related to the activity of endothelial lipase by use of compounds according to Formula (II): as defined in the specification and compositions comprising any of the compounds.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。 本公开还提供了一种通过使用根据式（II）的化合物来治疗与内皮脂肪酶活性相关的疾病或病症的新方法：如说明书中所定义和包含任何化合物的组合物。

公开(公告)号：US20140045811A1

公开(公告)日：2014-02-13

申请号：US13944921

申请日：2013-07-18

Applicant: Bristol-Myers Squibb Company

Inventor： Heather Finlay ,  Ji Jiang ,  Soong-Hoon Kim ,  Brandon Parkhurst ,  Jennifer X. Qiao ,  Tammy C. Wang ,  Zulan Pi ,  George O. Tora ,  John Lloyd ,  James A. Johnson

IPC: C07D277/64 ,  C07D417/10 ,  C07D417/12 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D277/64 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US12168655B2

公开(公告)日：2024-12-17

申请号：US17836596

申请日：2022-06-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Wei Meng ,  Hannguang J. Chao ,  Heather Finlay ,  R. Michael Lawrence ,  Michael C. Myers

IPC: C07D413/10 ,  C07D239/54 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US11008306B2

公开(公告)日：2021-05-18

申请号：US16864825

申请日：2020-05-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D405/12 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.