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11.发明公开公开(公告)号：US20240293810A1
公开(公告)日：2024-09-05
申请号：US18024878
申请日：2022-03-15
CPC classification number: B01L3/502715 , B01L3/502746 , G01K7/16
Abstract: The application provides a microfluidic chip, a temperature measurement method using the same, and an analysis device, which relates to the field of microfluidic technology. The microfluidic chip includes: a substrate and at least one microfluidic module located on the substrate, wherein the microfluidic module includes a droplet control unit and at least one temperature detection unit, and wherein the temperature detection unit includes a temperature sensor, a first lead group and a second lead group, the temperature sensor is fixed on the substrate, the first lead group and the second lead group are electrically connected with the temperature sensor respectively, the first lead group is configured to transmit a constant current to the temperature sensor, and the second lead group is configured to electrically connect the temperature sensor and an external voltmeter.
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公开(公告)号：US11291970B2
公开(公告)日：2022-04-05
申请号：US16071932
申请日：2018-01-02
Inventor： Yue Geng , Fengchun Pang , Peizhi Cai , Le Gu
IPC: B01L3/00 , B01J19/00 , C12Q1/6874 , C12Q1/6869
Abstract: A gene sequencing chip is provided, which includes: an upper substrate including a plurality of liquid inlets for inletting liquid drops; a lower substrate opposite to the upper substrate and spaced therefrom by a gap, the gap being provided for allowing the liquid drops to move therein, the lower substrate including a liquid drop operation region, the liquid drop operation region including a manipulation electrode array. The manipulation electrode array includes multiple first sub-arrays for preparing a gene library, multiple second sub-arrays for sequencing the gene library which is prepared, each first sub-array being adjacent to one of the multiple second sub-arrays. Based on the gene sequencing chip provided in this disclosure, operations to tiny liquid drops such as movement, fusion and splitting can be accurately manipulated by using digital microfluidic techniques, and all steps of the gene sequencing from library preparation to gene sequencing can be completed on one chip.
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公开(公告)号：US11103868B2
公开(公告)日：2021-08-31
申请号：US16338042
申请日：2018-10-11
Inventor： Fengchun Pang , Peizhi Cai , Yue Geng , Le Gu , Yingying Zhao , Haochen Cui , Nan Zhao , Yuelei Xiao , Hui Liao , Chuncheng Che
IPC: B01L3/00
Abstract: The present disclosure provides a microfluidic chip, a biological detection device and a method. The microfluidic chip includes: a first substrate and a second substrate that are oppositely disposed; a first electrode and a second electrode that are oppositely disposed between the first substrate and the second substrate, the first electrode including a plurality of spaced first electrode units, and the second electrode including a plurality of spaced second electrode units, wherein the first electrode units are disposed oppositely to the second electrode units in one-to-one correspondence; a first dielectric layer and a second dielectric layer between the first electrode and the second electrode; a first hydrophobic layer and a second hydrophobic layer between the first dielectric layer and the second dielectric layer, wherein a gap is between the first hydrophobic layer and the second hydrophobic layer.
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公开(公告)号：US10948815B2
公开(公告)日：2021-03-16
申请号：US16171195
申请日：2018-10-25
Inventor： Yue Geng , Peizhi Cai , Fengchun Pang , Le Gu , Chuncheng Che
Abstract: The present disclosure discloses a mask, which includes a first substrate and a second substrate. The mask further includes a polarity particle positioned between the first substrate and the second substrate. The polarity particle has a light absorption or light transmission effect. The first substrate includes a plurality of driving electrodes disposed toward the second substrate and arranged in an array. Each of the driving electrodes is configured to receive an electric signal and control the polarity particle to move to a designated driving electrode to form a pattern.
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公开(公告)号：US20190099756A1
公开(公告)日：2019-04-04
申请号：US15922084
申请日：2018-03-15
Inventor： Fengchun Pang , Peizhi Cai , Yue Geng , Le Gu , Chuncheng Che
IPC: B01L3/00 , B01L9/00 , B01F13/00 , G01N33/543
Abstract: The present disclosure provides a micro-fluidic chip, a driving method thereof, a micro-fluidic element and a biosensor. The micro-fluidic chip includes a photoelectric conversion layer, a first electrode, and a second electrode arranged opposite to the first electrode. A channel for droplets is arranged between the first electrode and the photoelectric conversion layer. The photoelectric conversion layer is arranged at a side of the second electrode adjacent to the first electrode and configured to convert an incident light beam into a charge signal to drive the droplets in the channel to move.
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Patent Agency Ranking
公开(公告)号：US12251698B2
公开(公告)日：2025-03-18
申请号：US17489920
申请日：2021-09-30
Inventor： Qiuxu Wei , Wenliang Yao , Yingying Zhao , Le Gu , Bolin Fan , Yongjia Gao
IPC: B01L3/00
Abstract: The disclosure provides a micro-fluidic chip, and belongs to the field of chip technology. The microfluidic chip provided in the present disclosure includes a plurality of microfluidic units, each microfluidic unit includes an operation region and a transition region located on at least one side of the operation region, the transition regions at adjacent side of two adjacent microfluidic units are disposed opposite to each other. Each microfluidic unit includes: a first substrate; a first electrode layer disposed on the first substrate, the first electrode layer including a plurality of first sub-electrodes located in the operation region and at least one second sub-electrode located in the transition region, and the at least one second sub-electrode configured to drive a droplet to move from one of the plurality of microfluidic units to an adjacent microfluidic unit.
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公开(公告)号：US11583855B2
公开(公告)日：2023-02-21
申请号：US17186186
申请日：2021-02-26
Inventor： Hui Liao , Yingying Zhao , Bolin Fan , Wenliang Yao , Nan Zhao , Le Gu , Yongjia Gao
IPC: B01L3/00 , G01N27/22 , G01N33/577
Abstract: The present disclosure discloses a microfluidic structure, a microfluidic chip and a detection method. The microfluidic structure includes: a first base substrate and a second base substrate opposite to each other, an antibody area located between the first base substrate and the second base substrate and storing an enzyme-labeled first antibody, a cleaning area storing cleaning liquid, a signal substrate area storing a signal substrate solution and a detection area with a second antibody and an ion sensitive film fixed thereon, wherein all channel areas from the antibody area, the cleaning area and the signal substrate area to the detection area each have a driving electrode structure driving liquid drops to move; and the detection area has a thin film transistor connected with the ion sensitive film.
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公开(公告)号：US11577246B2
公开(公告)日：2023-02-14
申请号：US16631780
申请日：2019-05-13
Inventor： Le Gu , Peizhi Cai , Fengchun Pang , Yue Geng , Yingying Zhao , Haochen Cui , Yuelei Xiao , Hui Liao , Wenliang Yao , Nan Zhao
Abstract: A microfluidic device and a detection method for the microfluidic device are provided. The microfluidic device includes a driving substrate configured to drive a movement of a droplet; and a position detector configured to detect a position of the droplet on the driving substrate.
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公开(公告)号：US11383238B2
公开(公告)日：2022-07-12
申请号：US16626490
申请日：2019-07-26
Inventor： Nan Zhao , Peizhi Cai , Haochen Cui , Yuelei Xiao , Fengchun Pang , Le Gu , Yingying Zhao , Hui Liao , Yue Geng , Wenliang Yao
Abstract: A microfluidic apparatus is provided. The microfluidic apparatus includes an electrochromic layer including a plurality of individually independently addressable regions; a microfluidic layer defining a microfluidic channel for allowing a microfluid to pass therethrough; and a plurality of photodetectors configured to detect light transmit through the microfluid. The electrochromic layer is configured to be switched between a first state in which the plurality of individually independently addressable regions of the electrochromic layer are substantially transmissive, and a second state in which at least a first one of the plurality of individually independently addressable regions of the electrochromic layer in a region corresponding to a position of the microfluid is substantially transmissive, at least a second one of the plurality of individually independently addressable regions of the electrochromic layer outside the region corresponding to the position of the microfluid is substantially non-transmissive.
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公开(公告)号：US11344891B2
公开(公告)日：2022-05-31
申请号：US16768558
申请日：2019-11-13
Inventor： Yingying Zhao , Peizhi Cai , Le Gu , Fengchun Pang , Yue Geng , Yuelei Xiao , Haochen Cui , Nan Zhao , Hui Liao , Wenliang Yao , Chuncheng Che
IPC: B01L3/00
Abstract: The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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