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公开(公告)号：US20230350100A1
公开(公告)日：2023-11-02
申请号：US18308189
申请日：2023-04-27
Applicant: Alcon Inc.
Inventor： Lisa Nicole Hutfluss , Jing Cheng , Feng Jing , Steve Yun Zhang , Michelle Plavnik
CPC classification number: G02B1/043 , B29D11/00134 , B29D11/00192 , B29K2083/00
Abstract: The invention provides a method for making silicone hydrogel contact lenses in a relatively efficient and consistent manner from a lens formulation (i.e., a polymerizable composition) including a thermal initiator having a 10-hour half-life temperature (T10hλ) under a controlled thermal curing scheme. A method of the invention comprises a step of curing the lens formulation in an oven according to a thermal curing profile that comprises or consists essentially of increasing the oven's temperature from room temperature or a temperature that is at least about 5° C. lower than T10hλ to a temperature that is at least 30° C. higher than T10hλ at a selected rate (e.g., from about 1° C./minute to about 10° C./minute). Under such a controlled thermal curing scheme, the lens diameter of the fully-hydrated silicone hydrogel contact lenses obtained according to a method of the invention does not vary significantly with the positions of the molds in the oven.
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公开(公告)号：US11629255B2
公开(公告)日：2023-04-18
申请号：US17205212
申请日：2021-03-18
Applicant: Alcon Inc.
Inventor： Zahra Bassampour , Jing Cheng , Steve Yun Zhang
IPC: C08L83/06 , C08F220/12 , C08G77/442 , G02B1/04
Abstract: The invention is generally related to an embedded silicone hydrogel contact lens comprising a silicone hydrogel material and a hydrophobic insert. The silicone hydrogel material comprises repeating units of at least one first polysiloxane vinylic crosslinker comprising hydrophilized siloxane units each having one methyl substituent and one organic radical including at least one H-bond donor (e.g., hydroxyl groups), wherein the content of said at least one H-bond donor is at least 0.8 meq/g relative to the molecular weight of said at least one first polysiloxane vinylic crosslinker. The hydrophobic insert is composed of a crosslinked polymeric material comprising at least 40% by mole of acrylic repeating units and at least 6% by mole of repeating units of at least one vinylic crosslinking agent. The embedded silicone hydrogel is not susceptible to delamination.
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公开(公告)号：US12194699B2
公开(公告)日：2025-01-14
申请号：US17710199
申请日：2022-03-31
Applicant: Alcon Inc.
Inventor： Zahra Bassampour , Chandana Kolluru , Steve Yun Zhang , Junhao Ge , Yang Zheng , Cornelius Daniel Niculas , David Andrew Icenogle , Jing Cheng , Yuan Chang , Augustine Twum Kumi , Michelle Plavnik
Abstract: The invention relates to a method for producing embedded hydrogel contact lenses involving a set of 3-mold halves consisting essentially of: one female lens mold half having a molding surface defining the anterior surface of a contact lens; one male lens mold half having a molding surface defining the posterior surface of the contact lens; and an insert mold half having a molding surface defining one of the front and back surfaces of an insert. One of the lens mold halves is used twice: first with the insert mold half for molding an insert during first curing process and then with the other lens mold half for molding an embedded hydrogel contact lens with the molded insert embedded partially or fully therein during second curing process. The invention also relates to embedded hydrogel contact lenses produced from a method of the invention.
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公开(公告)号：US11931454B2
公开(公告)日：2024-03-19
申请号：US17024268
申请日：2020-09-17
Applicant: Alcon Inc.
Inventor： Junhao Ge , Steve Yun Zhang , Daqing Wu , Jing Cheng
CPC classification number: A61K9/0051 , A61K9/06 , A61K45/06 , A61K47/32 , A61K47/36
Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.
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公开(公告)号：US11867874B2
公开(公告)日：2024-01-09
申请号：US17205169
申请日：2021-03-18
Applicant: Alcon Inc.
Inventor： Jing Cheng , Wei Liang , Steve Yun Zhang
CPC classification number: G02B1/043 , C08G77/06 , C08G77/32 , C08J3/246 , C08G2210/00 , C08G2270/00 , C08J2383/04 , C08J2433/08
Abstract: The invention is generally related to an insert for being embedded in a silicone hydrogel contact lens. The insert is made of a crosslinked materials which are rigid in dry state at room temperature (from about 22° C. to about 26° C.), have a high oxygen permeability and a high refractive index in fully hydrated state, and can become softer at a temperature great than 32° C. Such materials are useful for making inserts in embedded contact lenses for correcting corneal astigmatism, presbyopia, and color blindness lenses and for imparting photochromic characteristics to the lenses. The invention is also related to a method for making embedded silicone hydrogel contact lenses comprising an insert of the invention therein and to embedded silicone hydrogel contact lenses comprising an insert of the invention therein.
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Patent Agency Ranking
公开(公告)号：US11833771B2
公开(公告)日：2023-12-05
申请号：US17710248
申请日：2022-03-31
Applicant: Alcon Inc.
Inventor： Yuan Chang , Junhao Ge , Steve Yun Zhang , Michelle Plavnik , Yang Zheng , Jing Cheng , Augustine Twum Kumi
CPC classification number: B29D11/00134 , C08L83/14 , G02C7/04 , G02C7/102 , B29K2083/00 , C08L2203/02 , C08L2205/03
Abstract: Described herein is a method for producing a contact lens comprising a central photochromic zone that has a diameter of about 13 mm or less and is concentric with the central axis of the contact lens. The method comprises: applying, in the center of the molding surface of a male mold half, a drop (having a volume of about 5 μL or less) of a first polymerizable fluid composition containing at least one photochromic compound and a relatively-high molecular weight polysiloxane vinylic crosslinker for increasing the viscosity and adhesion on the molding surface of the male mold half; dosing a second polymerizable fluid composition in a female mold hald; closing the female mold hald with the male mold half with the drop thereon to form a molding assembly; and curing the second polymerizable fluid composition and the drop of the first polymerizable fluid composition in the molding assembly.
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公开(公告)号：US20220339895A1
公开(公告)日：2022-10-27
申请号：US17710248
申请日：2022-03-31
Applicant: Alcon Inc.
Inventor： Yuan Chang , Junhao Ge , Steve Yun Zhang , Michelle Plavnik , Yang Zheng , Jing Cheng , Augustine Twum Kumi
Abstract: Described herein is a method for producing a contact lens comprising a central photochromic zone that has a diameter of about 13 mm or less and is concentric with the central axis of the contact lens. The method comprises: applying, in the center of the molding surface of a male mold half, a drop (having a volume of about 5 μL or less) of a first polymerizable fluid composition containing at least one photochromic compound and a relatively-high molecular weight polysiloxane vinylic crosslinker for increasing the viscosity and adhesion on the molding surface of the male mold half; dosing a second polymerizable fluid composition in a female mold hald; closing the female mold hald with the male mold half with the drop thereon to form a molding assembly; and curing the second polymerizable fluid composition and the drop of the first polymerizable fluid composition in the molding assembly.
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公开(公告)号：US20220324187A1
公开(公告)日：2022-10-13
申请号：US17710199
申请日：2022-03-31
Applicant: Alcon Inc.
Inventor： Zahra Bassampour , Chandana Kolluru , Steve Yun Zhang , Junhao Ge , Yang Zheng , Cornelius Daniel Niculas , David Andrew Icenogle , Jing Cheng , Yuan Chang , Augustine Twum Kumi , Michelle Plavnik
Abstract: The invention relates to a method for producing embedded hydrogel contact lenses involving a set of 3-mold halves consisting essentially of: one female lens mold half having a molding surface defining the anterior surface of a contact lens; one male lens mold half having a molding surface defining the posterior surface of the contact lens; and an insert mold half having a molding surface defining one of the front and back surfaces of an insert. One of the lens mold halves is used twice: first with the insert mold half for molding an insert during first curing process and then with the other lens mold half for molding an embedded hydrogel contact lens with the molded insert embedded partially or fully therein during second curing process. The invention also relates to embedded hydrogel contact lenses produced from a method of the invention.
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公开(公告)号：US20210292558A1
公开(公告)日：2021-09-23
申请号：US17205212
申请日：2021-03-18
Applicant: Alcon Inc.
Inventor： Zahra Bassampour , Jing Cheng , Steve Yun Zhang
IPC: C08L83/06 , C08F220/12
Abstract: The invention is generally related to an embedded silicone hydrogel contact lens comprising a silicone hydrogel material and a hydrophobic insert. The silicone hydrogel material comprises repeating units of at least one first polysiloxane vinylic crosslinker comprising hydrophilized siloxane units each having one methyl substituent and one organic radical including at least one H-bond donor (e.g., hydroxyl groups), wherein the content of said at least one H-bond donor is at least 0.8 meq/g relative to the molecular weight of said at least one first polysiloxane vinylic crosslinker. The hydrophobic insert is composed of a crosslinked polymeric material comprising at least 40% by mole of acrylic repeating units and at least 6% by mole of repeating units of at least one vinylic crosslinking agent. The embedded silicone hydrogel is not susceptible to delamination.
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公开(公告)号：US20210077385A1
公开(公告)日：2021-03-18
申请号：US17024268
申请日：2020-09-17
Applicant: Alcon Inc.
Inventor： Junhao Ge , Steve Yun Zhang , Daqing Wu , Jing Cheng
Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.
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