公开(公告)号：US12071627B2

公开(公告)日：2024-08-27

申请号：US18458752

申请日：2023-08-30

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Ellen Reisinger ,  Sebastian Kügler ,  Hanan Al-Moyed

IPC分类号： C12N15/86 ,  A01K67/0276 ,  A61K38/17 ,  A61K48/00 ,  A61P27/16 ,  C07K14/47 ,  C12N5/0793 ,  C12N9/16 ,  C12N15/52 ,  C12N15/65 ,  C12N15/90

CPC分类号： C12N15/52 ,  A01K67/0276 ,  A61K38/1709 ,  A61K48/0075 ,  A61P27/16 ,  C07K14/47 ,  C12N5/062 ,  C12N9/16 ,  C12N15/65 ,  C12N15/86 ,  C12N15/902 ,  A01K2217/075 ,  A01K2227/103 ,  A01K2267/03 ,  C12N2310/20 ,  C12N2750/14143 ,  C12N2830/008 ,  C12Y301/03001

摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

公开(公告)号：US11993777B2

公开(公告)日：2024-05-28

申请号：US18458744

申请日：2023-08-30

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Ellen Reisinger ,  Sebastian Kügler ,  Hanan Al-Moyed

IPC分类号： C12N15/52 ,  A01K67/027 ,  A01K67/0276 ,  A61K38/17 ,  A61K48/00 ,  A61P27/16 ,  C07K14/47 ,  C12N5/0793 ,  C12N9/16 ,  C12N15/65 ,  C12N15/86 ,  C12N15/90

CPC分类号： C12N15/52 ,  A01K67/0276 ,  A61K38/1709 ,  A61K48/0075 ,  A61P27/16 ,  C07K14/47 ,  C12N5/062 ,  C12N9/16 ,  C12N15/65 ,  C12N15/86 ,  C12N15/902 ,  A01K2217/075 ,  A01K2227/103 ,  A01K2267/03 ,  C12N2310/20 ,  C12N2750/14143 ,  C12N2830/008 ,  C12Y301/03001

摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

公开(公告)号：US20230407315A1

公开(公告)日：2023-12-21

申请号：US18458744

申请日：2023-08-30

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Ellen Reisinger ,  Sebastian Kügler ,  Hanan Al-Moyed

IPC分类号： C12N15/52 ,  A01K67/027 ,  C12N15/65 ,  A61K48/00 ,  C07K14/47 ,  A61P27/16 ,  A61K38/17 ,  C12N5/0793 ,  C12N9/16 ,  C12N15/86 ,  C12N15/90

CPC分类号： C12N15/52 ,  A01K67/0276 ,  C12N15/65 ,  A61K48/0075 ,  C07K14/47 ,  A61P27/16 ,  A61K38/1709 ,  C12N5/062 ,  C12N9/16 ,  C12N15/86 ,  C12N15/902 ,  C12N2750/14143 ,  C12N2310/20 ,  C12N2830/008 ,  A01K2267/03 ,  A01K2217/075 ,  A01K2227/103 ,  C12Y301/03001

摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

公开(公告)号：US20230201372A1

公开(公告)日：2023-06-29

申请号：US17924933

申请日：2021-05-12

申请人： Akouos, Inc. ,  Taipei Veterans General Hospital

发明人： Emmanuel John Simons ,  Robert Ng ,  Yen-Fu Cheng

IPC分类号： A61K48/00 ,  A61K38/17 ,  C07K14/705 ,  C12N15/86 ,  A61P27/16

CPC分类号： A61K48/005 ,  A61K38/1709 ,  C07K14/705 ,  C12N15/86 ,  A61P27/16 ,  A61K48/0075 ,  C12N2750/14143

摘要： The present disclosure provides constructs comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a pendrin protein. Exemplary constructs include AAV constructs. Also provided are methods of using disclosed constructs for the treatment of hearing loss and/or deafness.

公开(公告)号：US20220267739A1

公开(公告)日：2022-08-25

申请号：US17697099

申请日：2022-03-17

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Robert Ng ,  Michael McKenna

IPC分类号： C12N7/00 ,  A61K9/00 ,  A61K48/00 ,  C07K16/22 ,  A61P27/16

摘要： Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.

公开(公告)号：US20210330814A1

公开(公告)日：2021-10-28

申请号：US17259661

申请日：2019-07-12

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Robert Ng

IPC分类号： A61K48/00 ,  C12N15/86 ,  C12N9/22 ,  C12N15/11 ,  C07K14/47 ,  C12N15/90

摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of a stereocilin protein, and the use of these compositions to treat non-syndromic sensorineural hearing loss in a subject.

公开(公告)号：US12077773B2

公开(公告)日：2024-09-03

申请号：US18485178

申请日：2023-10-11

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Robert Ng

IPC分类号： C12N15/86 ,  A61K48/00 ,  A61P27/16 ,  C07K14/47

CPC分类号： C12N15/86 ,  A61P27/16 ,  C07K14/47 ,  A61K48/00 ,  C12N2750/14143 ,  C12N2750/14144

摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

公开(公告)号：US20240139344A1

公开(公告)日：2024-05-02

申请号：US18269307

申请日：2021-12-22

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Robert Ng

IPC分类号： A61K48/00 ,  C07K14/705 ,  C12N15/86

CPC分类号： A61K48/0058 ,  A61K48/0075 ,  A61K48/0091 ,  C07K14/705 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14152 ,  C12N2830/008 ,  C12N2830/42 ,  C12N2830/50 ,  C12N2840/445

摘要： The present disclosure provides constructs comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a clarin 1 protein. Exemplary constructs include AAV constructs. Also provided are methods of using disclosed constructs for the treatment of hearing loss and/or deafness. Also provided are methods of using disclosed constructs for the treatment of vision loss.

公开(公告)号：US11807867B2

公开(公告)日：2023-11-07

申请号：US17816305

申请日：2022-07-29

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Robert Ng

IPC分类号： C12N15/86 ,  A61P27/16 ,  C07K14/47 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61P27/16 ,  C07K14/47 ,  A61K48/00 ,  C12N2750/14143 ,  C12N2750/14144

摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

公开(公告)号：US20230295287A1

公开(公告)日：2023-09-21

申请号：US18134095

申请日：2023-04-13

申请人： Akouos, Inc.

发明人： Emmanuel John Simons ,  Robert Ng ,  Michael McKenna

IPC分类号： C07K16/22 ,  C12N15/86 ,  C07K14/55 ,  C07K14/005 ,  A61K48/00 ,  A61P27/16

CPC分类号： C07K16/22 ,  C12N15/86 ,  C07K14/55 ,  C07K14/005 ,  A61K48/0066 ,  A61P27/16 ,  C12N2750/14143 ,  C12N2750/14152 ,  C07K2317/55 ,  C07K2317/24 ,  C07K2317/76

摘要： The present disclosure provides a construct comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a vascular endothelial growth factor (VEGF) binding agent or a portion thereof. In some embodiments, a construct is an AAV construct. In some embodiments, an AAV construct is a part of an AAV particle. Compositions comprising constructs and AAV particles described herein can be useful in treating hearing loss, for example, hearing loss associated with vestibular schwannoma.