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1.发明授权公开(公告)号：US11781145B2
公开(公告)日：2023-10-10
申请号：US17929647
申请日：2022-09-02
申请人： Akouos, Inc.
IPC分类号： C12N15/52 , A01K67/027 , A61K38/17 , A61K48/00 , A61P27/16 , C07K14/47 , C12N15/65 , C12N15/86 , C12N15/90 , C12N5/0793 , C12N9/16
CPC分类号： C12N15/52 , A01K67/0276 , A61K38/1709 , A61K48/0075 , A61P27/16 , C07K14/47 , C12N5/062 , C12N9/16 , C12N15/65 , C12N15/86 , C12N15/902 , A01K2217/075 , A01K2227/103 , A01K2267/03 , C12N2310/20 , C12N2750/14143 , C12N2830/008 , C12Y301/03001
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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2.发明公开公开(公告)号：US20240011039A1
公开(公告)日：2024-01-11
申请号：US18458752
申请日：2023-08-30
申请人： Akouos, Inc.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2750/14143 , C12N2750/14145
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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3.发明申请公开(公告)号：US20230090286A1
公开(公告)日：2023-03-23
申请号：US17929647
申请日：2022-09-02
申请人： AKOUOS, INC.
IPC分类号： C12N15/52 , A61K38/17 , A61K48/00 , A61P27/16 , C07K14/47 , C12N5/0793 , C12N9/16 , C12N15/65 , C12N15/86 , C12N15/90 , A01K67/027
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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4.发明授权公开(公告)号：US12071627B2
公开(公告)日：2024-08-27
申请号：US18458752
申请日：2023-08-30
申请人： Akouos, Inc.
IPC分类号： C12N15/86 , A01K67/0276 , A61K38/17 , A61K48/00 , A61P27/16 , C07K14/47 , C12N5/0793 , C12N9/16 , C12N15/52 , C12N15/65 , C12N15/90
CPC分类号： C12N15/52 , A01K67/0276 , A61K38/1709 , A61K48/0075 , A61P27/16 , C07K14/47 , C12N5/062 , C12N9/16 , C12N15/65 , C12N15/86 , C12N15/902 , A01K2217/075 , A01K2227/103 , A01K2267/03 , C12N2310/20 , C12N2750/14143 , C12N2830/008 , C12Y301/03001
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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5.发明授权公开(公告)号：US11993777B2
公开(公告)日：2024-05-28
申请号：US18458744
申请日：2023-08-30
申请人： Akouos, Inc.
IPC分类号： C12N15/52 , A01K67/027 , A01K67/0276 , A61K38/17 , A61K48/00 , A61P27/16 , C07K14/47 , C12N5/0793 , C12N9/16 , C12N15/65 , C12N15/86 , C12N15/90
CPC分类号： C12N15/52 , A01K67/0276 , A61K38/1709 , A61K48/0075 , A61P27/16 , C07K14/47 , C12N5/062 , C12N9/16 , C12N15/65 , C12N15/86 , C12N15/902 , A01K2217/075 , A01K2227/103 , A01K2267/03 , C12N2310/20 , C12N2750/14143 , C12N2830/008 , C12Y301/03001
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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6.发明公开公开(公告)号：US20230407315A1
公开(公告)日：2023-12-21
申请号：US18458744
申请日：2023-08-30
申请人： Akouos, Inc.
IPC分类号： C12N15/52 , A01K67/027 , C12N15/65 , A61K48/00 , C07K14/47 , A61P27/16 , A61K38/17 , C12N5/0793 , C12N9/16 , C12N15/86 , C12N15/90
CPC分类号： C12N15/52 , A01K67/0276 , C12N15/65 , A61K48/0075 , C07K14/47 , A61P27/16 , A61K38/1709 , C12N5/062 , C12N9/16 , C12N15/86 , C12N15/902 , C12N2750/14143 , C12N2310/20 , C12N2830/008 , A01K2267/03 , A01K2217/075 , A01K2227/103 , C12Y301/03001
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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7.发明授权公开(公告)号：US11525139B2
公开(公告)日：2022-12-13
申请号：US17378606
申请日：2021-07-16
申请人： Akouos, Inc.
IPC分类号： C12N15/52 , A01K67/027 , A61K38/17 , A61K48/00 , A61P27/16 , C07K14/47 , C12N15/65 , C12N15/86 , C12N15/90 , C12N5/0793 , C12N9/16
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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8.发明申请公开(公告)号：US20210363534A1
公开(公告)日：2021-11-25
申请号：US17378606
申请日：2021-07-16
申请人： Akouos, Inc.
IPC分类号： C12N15/52 , A01K67/027 , C12N15/65 , A61K48/00 , C07K14/47 , A61P27/16 , A61K38/17 , C12N5/0793 , C12N9/16 , C12N15/86 , C12N15/90
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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9.发明申请公开(公告)号：US20190185864A1
公开(公告)日：2019-06-20
申请号：US16327396
申请日：2017-08-23
申请人： Akouos, Inc. , Georg-August-Universitat Gottingen Stiftung Offentlichen Rechts, Universitatsmedizin, Represen
CPC分类号： C12N15/52 , A01K67/0276 , A01K2217/075 , A01K2227/103 , A01K2267/03 , A61K38/1709 , A61K48/0075 , A61P27/16 , C07K14/47 , C12N5/062 , C12N9/16 , C12N15/65 , C12N15/86 , C12N15/902 , C12N2310/20 , C12N2750/14143 , C12N2830/008 , C12Y301/03001
摘要： Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
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