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公开(公告)号：US20200230323A1
公开(公告)日：2020-07-23
申请号：US16839267
申请日：2020-04-03
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , A61M5/162 , A61M5/158 , A61M5/148 , A61M5/145 , A61M5/172 , A61M5/24 , B65B55/10 , B65B55/08 , B65B7/28 , B65B3/00
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US20190298927A1
公开(公告)日：2019-10-03
申请号：US16401471
申请日：2019-05-02
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , B65B55/10 , A61M5/162 , A61M5/24 , A61M5/172 , A61M5/145 , B65B55/08 , B65B7/28 , B65B3/00 , A61M5/158 , A61M5/148
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US20190143047A1
公开(公告)日：2019-05-16
申请号：US16154759
申请日：2018-10-09
Applicant: AMGEN INC.
Inventor： Julian Jazayeri , Ronald Forster , Jolita Seckute , Olivia Alice Henderson , Kristen Brown , Gregory Gordon , Rasmus Øhlenschlæger , Peter Dan Kaare Soelberg
Abstract: A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.
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公开(公告)号：US11904143B2
公开(公告)日：2024-02-20
申请号：US16609466
申请日：2018-06-04
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Ronald Forster , Joseph Michael Iglesias , Matias Melander , Rasmus Øhlenschlaeger , Christian Plambech , Lars Stenholt , Bjarke Lykke Ludvig Svendsen
CPC classification number: A61M5/3145 , A61M5/20 , A61M5/31583 , A61M2005/3143
Abstract: An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.
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公开(公告)号：US11110225B2
公开(公告)日：2021-09-07
申请号：US15974354
申请日：2018-05-08
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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Patent Agency Ranking
公开(公告)号：US20200179609A1
公开(公告)日：2020-06-11
申请号：US16687254
申请日：2019-11-18
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , A61M5/162 , A61M5/158 , A61M5/148 , A61M5/145 , A61M5/172 , A61M5/24 , B65B55/10 , B65B55/08 , B65B7/28 , B65B3/00
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US10537682B2
公开(公告)日：2020-01-21
申请号：US15047792
申请日：2016-02-19
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US09987428B2
公开(公告)日：2018-06-05
申请号：US14350687
申请日：2012-10-11
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/24 , A61M5/142
CPC classification number: A61M5/31 , A61M5/14244 , A61M5/1452 , A61M5/148 , A61M5/158 , A61M5/162 , A61M5/1626 , A61M5/172 , A61M5/2455 , A61M5/2466 , A61M2005/247 , A61M2005/2474 , A61M2005/3114 , A61M2207/00 , B65B3/003 , B65B7/2821 , B65B55/08 , B65B55/10
Abstract: An injector (100) may include a container (102) having a wall (110) with an interior surface (112) and a seal assembly (140) with an interior surface (142), the interior surfaces (110) of the wall (110) and the seal assembly (140) defining a closed sterile reservoir (150) filled with a drug product. The injector (100) may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle (180) having a point (182) disposed only partially through the seal assembly (140) in a storage state, and disposed through the interior surface (142) of the seal assembly (140) into the sterile reservoir (150) in a delivery state. Further, the injection may include an actuator (106) that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US20160199582A1
公开(公告)日：2016-07-14
申请号：US15040335
申请日：2016-02-10
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
CPC classification number: A61M5/31 , A61M5/14244 , A61M5/1452 , A61M5/148 , A61M5/158 , A61M5/162 , A61M5/1626 , A61M5/172 , A61M5/2455 , A61M5/2466 , A61M2005/247 , A61M2005/2474 , A61M2005/3114 , A61M2207/00 , B65B3/003 , B65B7/2821 , B65B55/08 , B65B55/10
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
Abstract translation: 注射器可以包括具有内表面的壁和具有内表面的密封组件的容器，壁的内表面和密封组件限定了充满药物的封闭的无菌容器。 注射器还可以包括流体输送系统，该流体输送系统包括清洁的，未被加热的刚性容器针，其具有仅在部分地通过密封组件处于储存状态的点，并且设置成通过密封组件的内表面输送到无菌容器中 州。 此外，注射可以包括适于将容器针从储存状态移动到输送状态的致动器。
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公开(公告)号：US11160931B2
公开(公告)日：2021-11-02
申请号：US16401471
申请日：2019-05-02
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/31 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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